Abstract
Phorbol 12-myristate 13-acetate (PMA) is a potent mouse skin tumor promoter which has been researched most intensively over the years in an attempt to understand the biochemical mechanisms involved in tumor promotion, PMA stimulates a multitude of cellular and biochemical reactions (82), Three of these, induction of ornithine decarboxylase (ODC) activity, hyperplasia and inflammation, correlate well with tumor promotion in mouse skin, and each is considered to be a necessary but insufficient event in this process (22, 27, 51, 58, 64, 70, 83) The release of metabolites of arachidonic acid (AA) is also thought to be important in view of the inhibitory effects of nonsteroidal anti-inflammatory drugs on PMA-induced ODC activity and tumor promotion (19, 48).
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Kozumbo, W.J., Cerutti, P.A. (1986). Antioxidants as Antitumor Promoters. In: Shankel, D.M., Hartman, P.E., Kada, T., Hollaender, A., Wilson, C.M., Kuny, G. (eds) Antimutagenesis and Anticarcinogenesis Mechanisms. Basic Life Sciences, vol 39. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5182-5_43
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