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Neoplasms of the Urethra

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Genitourinary Radiology: Kidney, Bladder and Urethra

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Abstract

Urethral cancer is a rare disease which may occur at any age but is observed more often during the seventh decade. It is usually considered more common in females, but a recent study shows in the United States an annual age-adjusted incidence rate of 4.3 per million men and 1.5 per million women. The incidence is higher in African Americans. Different histologic patterns of urethral tumors are recognized. The most common type of urethral malignancy is squamous cell carcinoma which accounts for about 80 % of cases in men and 60 % of cases in women. Transitional cell carcinoma is the second most common urethral malignancy in both sexes. In males, this lesion accounts for 15 % of total cases, in females for 20 % of patients. Other primary malignant tumors of the urethra are rare. Only sporadic cases of lymphoma, melanoma, and neuroendocrine tumors have been reported in the literature.

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Suggested Reading

  • Wasserman NF. Urethral neoplasms. In: Pollack H, McClennan B, editors. Clinical urography. 2nd ed. Philadelphia: Saunders; 2000. p. 1699–715.

    Google Scholar 

  • Ryu J, Kim B. MR imaging of the male and female urethra. Radiographics. 2001;21:1169–85.

    PubMed  CAS  Google Scholar 

  • Swartz MA, Porter MP, Lin DW, Weiss NS. Incidence of primary urethral carcinoma in the United States. Urology. 2006;68:1164–8.

    Article  PubMed  Google Scholar 

  • Ryu JA, Kim B. MR imaging of primary urethral lymphoma in a man. AJR Am J Roentgenol. 2003;181:600–1.

    PubMed  Google Scholar 

  • Morita T, Suzuki H, Goto K, Hirota N, Tokue A. Primary malignant melanoma of male urethra with fistula formation. Urol Int. 1991;46:114–5.

    Article  PubMed  CAS  Google Scholar 

  • Altintas S, Blockx N, Huizing MT, et al. Small-cell carcinoma of the penile urethra: a case report and a short review of the literature. Ann Oncol. 2007;18:801–4.

    Article  PubMed  CAS  Google Scholar 

  • Richie JP, Withers G, Ehrlich RM. Ureteral obstruction secondary to metastatic tumors. Surg Gynecol Obstet. 1979;148:355–7.

    PubMed  CAS  Google Scholar 

  • Ray B, Canto AR, Whitmore Jr WF. Experience with primary ­carcinoma of the male urethra. J Urol. 1977;117:591–4.

    PubMed  CAS  Google Scholar 

  • Segal AS, Kan Ia D, Dunaevskii Ia L, Dolgopiatov DG. Benign neoplasms of the urethra in men. Urol Nefrol (Mosk). 1996;(3):39–42.

    Google Scholar 

  • Downs RA. Congenital polyps of the prostatic urethra. A review of the literature and report of two cases. Br J Urol. 1970;42:76–85.

    Article  PubMed  CAS  Google Scholar 

  • Isaac J, Snow B, Lowichik A. Fibroepithelial polyp of the prostatic urethra in an adolescent. J Pediatr Surg. 2006;41:e29–31.

    Article  PubMed  Google Scholar 

  • Bortolozzi G, Grasso A, Zasso B. Leiomyoma of the female urethra. A case report and review. Clin Exp Obstet Gynecol. 1995;22:169–71.

    PubMed  CAS  Google Scholar 

  • Mira JL, Fan G. Leiomyoma of the male urethra: a case report and review of the literature. Arch Pathol Lab Med. 2000;124:302–3.

    PubMed  CAS  Google Scholar 

  • Pavlica P, Barozzi L, Menchi I. Imaging of male urethra. Eur Radiol. 2003;13:1583–96.

    Article  PubMed  Google Scholar 

  • Pavlica P, Menchi I, Barozzi L. New imaging of the anterior male urethra. Abdom Imaging. 2003;28:180–6.

    Article  PubMed  CAS  Google Scholar 

  • Kawashima A, Sandler CM, Wasserman NF, LeRoy AJ, King Jr BF, Goldman SM. Imaging of urethral disease: a pictorial review. Radiographics. 2004;24 Suppl 1:S195–216.

    Article  PubMed  Google Scholar 

  • Eaton J, Richenberg J. Imaging of the urethra: current status. Imaging. 2005;17:139–49.

    Article  Google Scholar 

  • Pavlica P, Bartolone A, Gaudiano C, Barozzi L. Female paraurethral leiomyoma: ultrasonographic and magnetic resonance imaging findings. Acta Radiol. 2004;45:796–8.

    Article  PubMed  CAS  Google Scholar 

  • Yang JM, Yang SH, Huang WC. Two- and three-dimensional ­sonographic findings in a case of distal urethral obstruction due to a paraurethral tumor. Ultrasound Obstet Gynecol. 2005;25:519–21.

    Article  PubMed  Google Scholar 

  • Fontana D, Porpiglia F, Morra I, Destefanis P. Transvaginal ultrasonography in the assessment of organic diseases of female urethra. J Ultrasound Med. 1999;18:237–41.

    PubMed  CAS  Google Scholar 

  • Nash PA, McAninch JW, Bruce JE, Hanks DK. Sono-urethrography in the evaluation of anterior urethral strictures. J Urol. 1995;154:72–6.

    Article  PubMed  CAS  Google Scholar 

  • Desser TS, Nino-Murcia M, Olcott EW, Terris MK. Advantages of performing sonourethrography with lidocaine hydrochloride jelly in a prepackaged delivery system. AJR Am J Roentgenol. 1999;173:39–40.

    PubMed  CAS  Google Scholar 

  • Siegel CL, Middleton WD, Teefey SA, Wainstein MA, McDougall EM, Klutke CG. Sonography of the female urethra. AJR Am J Roentgenol. 1998;170:1269–74.

    PubMed  CAS  Google Scholar 

  • Prasad SR, Menias CO, Narra VR, et al. Cross-sectional imaging of the female urethra: technique and results. Radiographics. 2005;25:749–61.

    Article  PubMed  Google Scholar 

  • Benson Jr RC, Tunca JC, Buchler DA, Uehling DT. Primary carcinoma of the female urethra. Gynecol Oncol. 1982;14:313–8.

    Article  PubMed  Google Scholar 

  • Bracken RB, Johnson DE, Miller LS, Ayala AG, Gomez JJ, Rutledge F. Primary carcinoma of the female urethra. J Urol. 1976;116:188–92.

    PubMed  CAS  Google Scholar 

  • Ikeda R, Suga K, Suzuki K. MRI appearance of a leiomyoma of the female urethra. Clin Radiol. 2001;56:76–9.

    Article  PubMed  CAS  Google Scholar 

  • Hricak H, Secaf E, Buckley DW, Brown JJ, Tanagho EA, McAninch JW. Female urethra: MR imaging. Radiology. 1991;178:527–35.

    PubMed  CAS  Google Scholar 

  • Kim B, Kawashima A, LeRoy AJ. Imaging of the male urethra. Semin Ultrasound CT MR. 2007;28:258–73.

    Article  PubMed  Google Scholar 

  • Singh AK, Gonzalez-Torrez P, Kaewlai R, Tabatabaei S, Harisinghani MG. Imaging of penile neoplasm. Semin Ultrasound CT MR. 2007;28:287–96.

    Article  PubMed  Google Scholar 

  • Shirkhoda A, Salmanzadeh A, Jafri SZ, Konez O, Spencer W. Urethral leiomyosarcoma: evaluation by MRI with pathologic correlation. J Comput Assist Tomogr. 2000;24:423–5.

    Article  PubMed  CAS  Google Scholar 

  • Van der Aa F, Joniau S, Van Poppel H, et al. A large primary ­malignant melanoma of the female urethra presenting as postmenopausal vaginal bleeding. J Pelvic Surg. 2002;8:47–9.

    Google Scholar 

  • Li H, Sugimura K, Boku M, Kaji Y, Tachibana M, Kamidono S. MR findings of prostatic urethral polyp in an adult. Eur Radiol. 2003;13 Suppl 4:L105–8.

    Article  PubMed  Google Scholar 

  • Mueller-Lisse UG, Scher B, Scherr MK, Seitz M. Functional ­imaging in penile cancer: PET/computed tomography, MRI, and sentinel lymph node biopsy. Curr Opin Urol. 2008;18:105–10.

    Article  PubMed  Google Scholar 

  • Ho KL, Hayden MT. Sarcoidosis of urethra simulating carcinoma. Urology. 1979;13:197–9.

    Article  PubMed  CAS  Google Scholar 

  • Kawashima A, Sandler CM, Wasserman NF, LeRoy AJ, King Jr BF, Goldman SM. Imaging of urethral disease: a pictorial review. Radiographics. 2004;24 Suppl 1:S195–216.

    Article  PubMed  Google Scholar 

  • Pavlica P, Barozzi L, Menchi I. Imaging of male urethra. Eur Radiol. 2003;13:1583–96.

    Article  PubMed  Google Scholar 

  • Prasad SR, Menias CO, Narra VR, et al. Cross-sectional imaging of the female urethra: technique and results. Radiographics. 2005;25:749–61.

    Article  PubMed  Google Scholar 

  • Ryu J, Kim B. MR imaging of the male and female urethra. Radiographics. 2001;21:1169–85.

    PubMed  CAS  Google Scholar 

  • Wasserman NF. Urethral neoplasms. In: Pollack H, McClennan B, ­editors. Clinical urography. 2nd ed. Philadelphia: Saunders; 2000. p. 1699–715.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Radiology, Cattinara Hospital, University Hospital Riuniti Trieste, Strada di Fiume 447, Trieste, 34124, Italy

    Michele Bertolotto M.D. & Francesca Cacciato M.D.

  2. S.S: D. Radiologia d’Urgenza, Dipartimento di Radiologia e Diagnostica per Immagini, Maggiore Hospital, University Hospital Parma, Ospedale Maggiore Via Gramsci 14, Parma, 43100, Italy

    Massimo Valentino M.D.

  3. Department of Radiology, University Hospital S. Orsola-Malpighi, Via Massarenti 9, Bologna, 40138, Italy

    Libero Barozzi M.D. & Pietro Pavlica M.D.

  4. Department of Radiology, S. Corona Hospital, Via XXV Aprile, Pietra Ligure, Savona, 17927, Italy

    Giovanni Serafini M.D.

  5. Clinica Privata Villalba Hospital, Bologna, Italy

    Pietro Pavlica M.D.

  6. Division of Anatomic Pathology, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA

    Gregory T. MacLennan M.D.

Authors
  1. Michele Bertolotto M.D.
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  2. Massimo Valentino M.D.
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  3. Libero Barozzi M.D.
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  4. Giovanni Serafini M.D.
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  5. Francesca Cacciato M.D.
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  6. Pietro Pavlica M.D.
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  7. Gregory T. MacLennan M.D.
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Corresponding author

Correspondence to Michele Bertolotto M.D. .

Editor information

Editors and Affiliations

  1. Medical Center, University of Rochester, Elmwood Avenue 601, Rochester, 14642, New York, USA

    Vikram S. Dogra

  2. , Pathology, University Hospitals Case Medical Center, Adelbert Road 2085, Cleveland, 44106, Ohio, USA

    Gregory T. MacLennan

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Bertolotto, M. et al. (2013). Neoplasms of the Urethra. In: Dogra, V., MacLennan, G. (eds) Genitourinary Radiology: Kidney, Bladder and Urethra. Springer, London. https://doi.org/10.1007/978-1-84800-245-6_14

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  • DOI: https://doi.org/10.1007/978-1-84800-245-6_14

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  • Online ISBN: 978-1-84800-245-6

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