Definition
Myocardial infarction (MI) is defined as the death of myocardial cells due to a prolonged time of ischemia (Thygesen et al. 2018). Clinically, the term should be used when acute myocardial injury is detected by abnormal cardiac biomarkers (such as troponins, myoglobin, creatine kinase-MB isoform) in the setting of evidence of acute myocardial ischemia (Thygesen et al. 2018). If there is no conclusive evidence to support the theory of myocardial ischemia but elevated cardiac biomarkers are present, the term myocardial injury should be used according to the latest universal definition of myocardial infarction published in 2018 as a consensus statement of many major cardiovascular societies (Thygesen et al. 2018).
Historically, MI is one of the most severe and furthermore most feared complication of progressive coronary artery disease (CAD). CAD refers to an atherosclerotic process taking place in the...
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Westphal, J.G., Schulze, P.C. (2021). Myocardial Infarction. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-21573-6_6215-1
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DOI: https://doi.org/10.1007/978-3-030-21573-6_6215-1
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