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Multitarget Activities of Inositol and Inositol Hexakisphosphate

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Approaching Complex Diseases

Part of the book series: Human Perspectives in Health Sciences and Technology ((HPHST,volume 2))

Abstract

Multiple health beneficial effects have been shown for inositol hexakisphosphate (IP6) and its parent compound myo-inositol (Ins) in animal and human studies. However, the most striking is their consistent and reproducible anticancer effect, actively investigated and demonstrated in various experimental models during the last decades. Key molecular targets for cancer are PI3K/Akt, MAPK, PKC, AP-1 and NF-κB. Reduced burden of chemotherapy side-effects in cancer patients receiving IP6 alone or in combination with Ins, have been reported. However, modulation of both insulin resistance and cancer by Ins and IP6 have been indicated, and therefore there is a need for specific, randomized clinical trials and further mechanistic studies.

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  1. Department of Medical and Research Technology and Department of Pathology, University of Maryland School of Medicine, Baltimore, MD, USA

    Ivana Vucenik

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Correspondence to Ivana Vucenik .

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  1. Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy

    Mariano Bizzarri

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Vucenik, I. (2020). Multitarget Activities of Inositol and Inositol Hexakisphosphate. In: Bizzarri, M. (eds) Approaching Complex Diseases. Human Perspectives in Health Sciences and Technology, vol 2. Springer, Cham. https://doi.org/10.1007/978-3-030-32857-3_15

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