Abstract
The basic tissue engineering principle of musculoskeletal tissue repair is the delivery of functionally active cells within an appropriate carrier system to the damaged site, with a view to restore the original architecture and function of pathologically altered tissue. This approach comprises the interactive triad of responsive cells, a supportive matrix, and bio active molecules promoting differentiation and regeneration. New developments in cell culturing techniques, delivery systems and materials, and regenerative concepts for the engineering of cartilage tissue are discussed.
Reprinted with permission from Sittinger M (2003) Engineering cartilage structures. In: Sandell L (ed) Tissue engineering. American Academy of Orthopaedic Surgeons, Rosemont. In press.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Benya PD, Shaffer JD (1982) Dedifferentiated chondrocytes re-express the differentiated collagen phenotype when cultured in agarose gels. Cell 30:215–224
Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L (1994) Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med 331:889–895
Cao Y, Rodriguez A, Vacanti M, Ibarra C, Arevalo C, Vacanti CA (1998) Comparative study of use of poly(glycolic acid), calcium alginate and pluronics in the engineering of autologous porcine cartilage. J Biomater Sci Polym Ed 9:475–487
Erggelet C, Sittinger M, Lahm A (2003) The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint. Arthroscopy 19:108–110
Haisch A, Klaring S, Groger A, Gebert C, Sittinger M (2002) A tissue-engineering model for the manufacture of auricular-shaped cartilage implant. Eur Arch Otorhinolaryngol 259:316–312
Kadiyala S, Young RG, Thiede MA, Bruder SP (1997) Culture expanded canine mesenchymal stem cells possess osteochondrogenic potential in vivo and in vitro. Cell Transplant 6:125–134
Kaps C, Bramlage C, Smolian H et al. (2002) Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction. Arthritis Rheum 46:149–162
Kreklau B, Sittinger M, Mensing MB et al. (1999) Tissue engineering of biphasic joint cartilage transplants. Biomaterials 20:1743–1749
Lindenhayn K, Perka C, Spitzer R, Heilmann H, Pommerening K, Mennicke J, Sittinger M (1998) Retention of hyaluronic acid in alginate beads: Aspects for in vitro cartilage engineering. Biomed Mater Res 44:149–155
Minuth WW, Sittinger M, Kloth S (1998) Tissue engineering-generation of differential artificial tissues for biomedical applications. Cell Tiss Res 291:1–11
Perka C, Sittinger M, Schultz O, Spitzer RS, Schlenzka D, Burmester GR (2000) Tissue engineered cartilage repair using cryopreserved and noncryopreserved chondrocytes. Clin Orthop 378:245–254
Risbud MV, Sittinger M (2002) Tissue engineering: advances in in vitro cartilage generation. Trends Biotechnol 20:351–356
Risbud M, Ringe J, Bhonde R, Sittinger M (2001) In vitro expression of cartilage-specific markers by chondrocytes on a biocompatible hydrogel: implications for engineering cartilage tissue. Cell Transplant 10:775–763
Schultz O, Sittinger M, Haeupl T, Burmester GR (2000) Emerging strategies of bone and joint repair. Arthritis Res 2:433–436
Sittinger M, Bujia J, Rotter N, Reitzel D, Minuth WW, Burmester GR (1996) Tissue engineering and autologous transplant formation: practical approaches with resorbable biomaterials and new cell culture techniques. Biomaterials 17:237–242
Sittinger M, Lukanoff B, Burmester GR, Dautzenberg H (1996) Encapsulation of artificial tissues in polyelectrolyte complexes: Preliminary studies. Biomaterials 17:1049–1051
Sittinger M, Schultz O, Keyszer G, Minuth WW, Burmester GR (1997) Artificial tissues in perfusion culture. Int J Artif Org 20:57–62
Speer DP, Chvapil M, Volz RG, Holmes MD (1991) Enhancement of healing in osteochondral defects by collagen sponge implants. Clin Orthop 144:326–335
Tomihata K, Ikada Y (1997) Preparation of cross-linked hyaluronic acid films of low water content. Biomaterials 18:189–195
van Beuningen HM, Glansbeek HL, Kraan van der PM, Berg van den WB (1998) Differential effects of local application of BMP-2 or TGF-(beta)l on both articular cartilage compositions and osteophyte formation. Ostheoarthritis Cartilage 6:306–317
van Beuningen HM, Glansbeek HL, Kraan van der PM, Berg van den WB (2000) Osteoarthritis-like changes in the murine knee joint resulting from intra-articular transforming growth factor-(beta) injection. Ostheoarthritis Cartilage 8:25–33
Verbruggen G, Veys EM, Wieme N, Malfait AM, Gijselbrecht L, Nimmegrees J, Almquist KF, Broddelez C (1990) The synthesis and immobilization of cartilage-specific proteoglycan by human chondrocytes in different concentrations of agarose. Clin Exp Rheumatol 8:371–378
von Schroeder HP, Kwan M, Amiel D, Coutts RD (1991) The use of polylactic acid matrix and periostal grafts for the reconstruction of rabbit knee articular defects. J Biomed Mater Res 25:329–339
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Sittinger, M. (2003). Engineering Cartilage Structures. In: Hendrich, C., Nöth, U., Eulert, J. (eds) Cartilage Surgery and Future Perspectives. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19008-7_8
Download citation
DOI: https://doi.org/10.1007/978-3-642-19008-7_8
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-01054-8
Online ISBN: 978-3-642-19008-7
eBook Packages: Springer Book Archive