Skip to main content

In-vitro-Fertilisation

  • Chapter
Weibliche Sterilität

Zusammenfassung

Seit nahezu 20 Jahren werden die Techniken der extrakorporalen Befruchtung erfolgreich angewandt. Hierbei findet die Zeugung, die in vivo nicht erfolgen kann, außerhalb des Körpers (in vitro) statt. Voraussetzung hierfür ist das Zusammenbringen einer reifen Oozyte, die die 1. Reifeteilung vollzogen hat (Metaphase II), und eines befruchtungsfähigen Spermiums unter optimalen Bedingungen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literatur

  • Asch RH (1991) Uterine versus tubal embryo transfer in human. Comparative analysis of implantation, pregnancy and live birth rates. Ann NY Acad Sci 626: 461

    Article  PubMed  CAS  Google Scholar 

  • Behre HM, Yeung CH, Nieschlag E (1996) Diagnostik der Infertilität und des Hypogonadis-mus. In: Nieschlag E, Behre HM (Hrsg) Andrologie. Grundlagen und Klinik der repro-duktiven Gesundheit des Mannes. Springer, Berlin Heidelberg New York Tokio, S 91–117

    Google Scholar 

  • Burgus R, Butcher M, Amoss M et al. (1972) Primary structure of ovine hypothalamic lutei-nizing hormone releasing factor (LRF). Proc Natl Acad Sci USA 69: 278–282

    Article  PubMed  CAS  Google Scholar 

  • Chang MC (1959) Fertilization of rabbit ova in vitro. Nature 184: 466

    Article  PubMed  Google Scholar 

  • Chetkowski RJ, Kruse LR, Nass TE (1989) Improved pregnancy outcome with the addition of leuproline acetate to gonadotropins for in-vitro fertilization. Fertil Steril 52: 250–255

    PubMed  CAS  Google Scholar 

  • Diedrich K (1987) Unerwünschte Kinderlosigkeit. In: Martius D (Hrsg) Differentialdiagnose in Geburtshilfe und Gynäkologie, Bd 2 Gynäkologie. Thieme, Stuttgart, S 84–100

    Google Scholar 

  • Diedrich K (1990) Neue Wege in Diagnostik und Therapie der Sterilität. Enke, Stuttgart

    Google Scholar 

  • Diedrich K, Wildt L, Diedrich C, Van der Ven H, Al-Hasani S, Lehmann F, Krebs D (1985) Ovarielle Stimulation für die In-vitro-Fertilisation. Fertilität 1: 26

    Google Scholar 

  • Diedrich K, Van der Ven H, Al-Hasani S, Krebs D (1988) Ovarian stimulation for in vitro fertilization. Hum Reprod 3: 39–44

    PubMed  CAS  Google Scholar 

  • Diedrich K, Al-Hasani S, Van der Ven H, Diedrich C, Krebs D (1990) In-vitro-Fertilisation und Embryotransfer. In: Diedrich K (Hrsg) Neue Wege in Diagnostik und Therapie der Sterilität. Enke, Stuttgart, S 169–195

    Google Scholar 

  • Diedrich K, Diedrich C, Santos E et al. (1994) Suppression of the endogenous luteinizing hormone surge by the gonadotropin-releasing hormone antagonist Cetrorelix during ovarian stimulation. Hum Reprod 9: 788–791

    PubMed  CAS  Google Scholar 

  • Diedrich K, Felberbaum R, Küpker W, Al-Hasani S (1995) New approaches to male infertility: IVF and microinjection. Int J Androl 18: 78

    PubMed  Google Scholar 

  • Edwards RG (1981) Test tube babies. Nature 293: 253

    Article  PubMed  CAS  Google Scholar 

  • Edwards RG, Steptoe PC (1974) Control of human ovulation, fertilization and implantation. Proc R Soc Med 67: 932

    PubMed  CAS  Google Scholar 

  • Edwards RG, Lobo RA, Bouchard P (1996) Time to revolutionise ovarian stimulation. Hum Reprod 11: 917–919

    Article  PubMed  CAS  Google Scholar 

  • Eshkol A, Lunenfeld B (1967) Purification and separation of follicle stimulation hormone (FSH) and luteinizing hormone (LH) from human menopausal gonadotropine (HMG). Effects of a biologically apparently pure FSH preparation on ovaries and uteri of intact immature mice. Acta Endocrinol Copenh 54: 91–95

    PubMed  CAS  Google Scholar 

  • Feichtinger W (1991) Environmental factors and fertility. Hum Reprod 6: 1170–1175

    PubMed  CAS  Google Scholar 

  • Felberbaum R, Diedrich K (1996) Klinischer Einsatz der GnRH-Analoga im Rahmen der Sterilitätstherapie: Agonisten und Antagonisten. Gynäkologe 6: 420–432

    Article  Google Scholar 

  • Felberbaum RE, Reissmann T, Küpker W, Bauer 0, Al-Hasani S, Diedrich C, Diedrich K (1995) Fertilization rate and amount of human menopausal gonadotropin needed in controlled ovarian hyperstimulation under low-dose gonadotropin releasing hormone antagonist treatment. Hum Reprod 10: 8

    Article  Google Scholar 

  • Felberbaum R, Reissmann T, Küpker Wet al. (1996) Hormone profiles under ovarian stimulation with human menopausal gonadotropin (hMG) and concomitant administration of the gonadotropin-releasing hormone (GnRH)-antagonist Cetrorelix at different dosages. J Assist Reprod Genet 13: 216

    Article  PubMed  CAS  Google Scholar 

  • Fisch B, Avrech OM, Pinkas H, Neri A, Rufas O, Ovadia J (1995) Superovulation before IVF by recombinant versus urinary human FSH (combined with a long GnRH analog protocol): a comparative study. J Assist Reprod Genet 12: 26–31

    Article  PubMed  CAS  Google Scholar 

  • Fleming R, Haxton MJ, Hamilton MPR, McCune GS, Black WP, McNaughton MC, Coutts JRT (1985) Successful treatment of infertile women with oligomenorrhea using a combination of an LHRH agonist and exogenous gonadotropins. Br J Obstet Gynecol 92: 369–373

    Article  CAS  Google Scholar 

  • Gembruch U, Diedrich K, Al-Hasani S, Welker B, Wahode J, Van der Ven H, Krebs D (1988) Transvaginale-ultraschallkontrollierte Follikelpunktion. Geburtshilfe Frauenheilkd 48: 617–624

    Article  PubMed  CAS  Google Scholar 

  • Gemzell C (1969) Treatment of female and male sterility with human gonadotropins. Acta Obstet Gynecol Scand 48 [Suppl 11: 17–30

    Article  PubMed  Google Scholar 

  • Gerhard I, Runnebaum B (1992) Schadstoffe und Fertilitätsstörungen–Genußgifte. Geburtshilfe Frauenheilkd 52: 509–515

    Article  PubMed  CAS  Google Scholar 

  • Gordon K, Hodgen GD (1993) Evolving role of Gonadotropin releasing hormone antagonists. Trends Endocrinol Metab 3: 259

    Google Scholar 

  • Grunwald K, Rabe T, Runnebaum B (1997) Physiology of the menstrual cycle. In: Rabe T, Diedrich K, Runnebaum B (eds) Manual of assisted reproduction. Springer, Berlin Heidelberg New York Tokyo, pp 22–77

    Chapter  Google Scholar 

  • Hammerstein J (1969) Mode of action of clomiphene. Inhibitory effect of clomiphene-citrat on the formation of progesterone from acetate-1–14C by human corpus luteum slices in vitro. Acta Endocrinol Copenh 60: 635–644

    PubMed  CAS  Google Scholar 

  • Heape W (1891) Preliminary note on the transplantation and growth of mammalian ova within a uterine foster mother. Proc R Soc 48: 457–458

    Article  Google Scholar 

  • Hillier SG (1994) Curent concepts of the role of FSH and LH in folliculogenesis. Hum Re-prod 9: 188–191

    CAS  Google Scholar 

  • Homburg R, Eshel A, Abdalla HI et al. (1988) Growth hormon facilitates ovulation induction by gonadotropins. Clin Endocrinol 29: 113

    Article  CAS  Google Scholar 

  • IVF-Register 1996

    Google Scholar 

  • Keller R, Günther HL, Kaiser P (1992) Embryonenschutzgesetz. Kommentar zum Embryonenschutzgesetz. Kohlhammer, Stuttgart

    Google Scholar 

  • Klingmüller D, Diedrich K, Sommer L (1993) Effect of the GnRH antagonist Cetrorelix in normal women. Gynecol Endocrinol 7: 2

    Google Scholar 

  • Knobil E (1980) The neuroendocrine control of the menstrual cycle. Recent Prog Horm Res 36: 53–88

    PubMed  CAS  Google Scholar 

  • Küpker W, Al-Hasani S, Bauer O, Diedrich K (1994) Neue Techniken der assistierten Befruchtung. Fertilität 10: 216–220

    Google Scholar 

  • Küpker W, Al-Hasani S, Diedrich K (1996) Techniken der assistierten Reproduktion. In: Praxis der Spermatologie. Atlas und Anleitung, 2. Aufl. Springer, Berlin Heidelberg New York Tokio, S 89–113

    Chapter  Google Scholar 

  • Lavie P, Kripke DF (1981) Ultradian circa 1.5 hour rhythms: a multioscillatory system. Life Sci 29: 2445

    Article  PubMed  CAS  Google Scholar 

  • Lenz S, Lauritzen SJG, Kjellow M (1981) Collection of human oocytes for in vitro fertilization by ultrasonically guided follicular puncture. Lancet 1: 1163

    Article  PubMed  CAS  Google Scholar 

  • Leyendecker G, Wildt L, Hansmann M (1980) Pregnancies following chronic intermittent (pulsatile) administration of GnRH by means of a portable pump (Zyklomat) - a new approach to the treatment of infertility in hypothalamic amenorrhea. J Clin Endocrinol Metab 51: 1214

    Article  PubMed  CAS  Google Scholar 

  • Lopata A (1983) Concepts in human in vitro fertilization and embryo transfer. Fertil Steril 40: 289–301

    PubMed  CAS  Google Scholar 

  • Lopata A, Johnson IWH, Leeton JF, Muchniki D, McTalbot J, Wood C (1974) Collection of human oocytes at laparoscopy and laparotomy. Fertil Steril 25: 1030–1038

    PubMed  CAS  Google Scholar 

  • Loumaye E (1990) The control of endogenous secretion of LH by gonadotropin-releasing hormone agonists during ovarian hyperstimulation for in-vitro fertilization and embryo transfer. Hum Reprod 5: 557–576

    Google Scholar 

  • Ludwig G, Frick J, Rovan E (1996) Praxis der Spermatologie. Springer, Berlin Heidelberg New York Tokio

    Book  Google Scholar 

  • Lunenfeld B, Eshkol A (1969) Immunology of follicle-stimulating hormone and luteinizing hormone. Vitam Horm 27: 131–197

    Article  PubMed  CAS  Google Scholar 

  • March CM (1993) Ovulation induction. J Reprod Med 38: 335–346

    PubMed  CAS  Google Scholar 

  • Menken I, Rock J (1948) In-vitro fertilization and cleavage of human ovarian eggs. Am J Obstet Gynecol 55: 440–451

    Google Scholar 

  • Pincus G, Enzmann EV (1934) Can mammalian eggs undergo normal development in vitro? Proc Natl Acad Sci 20: 121–122

    Article  PubMed  CAS  Google Scholar 

  • Rabe T, Diedrich K, Eberhardt J, Küpker W (1997) In vitro fertilization. In: Rabe T, Diedrich K, Runnebaum B (eds) Manual of assisted reproduction. Springer, Berlin Heidelberg New York Tokyo, pp 252–311

    Chapter  Google Scholar 

  • Schenk SL (1880) Das Säugethierei künstlich befruchtet ausserhalb des Mutterthiers. Mitt Embryo Inst Wien, Bd 9

    Google Scholar 

  • Schmutzler RK, Diedrich K (1990) Basic and clinical aspects of GnRH-agonists in reproduction. Int J Gynec Obstet 32: 311–324

    Article  CAS  Google Scholar 

  • Siebzehnrübel E, Todorow S, Spitzer M, Neuwinger J, Wildt L, Lang N (1993) Die Erweiterung des Konzepts der extrakorporalen Befruchtung durch die Kryokonservierung imprägnierter Eizellen. Geburtshilfe Frauenheilkd 53: 359–365

    Article  Google Scholar 

  • Smitz J, Devroey P, Braeckmans P et al. (1987) Management of failed cycles in an IVF/GIFT programme with the combination of a GnRH analog and HMG. Hum Reprod 2: 309–314

    PubMed  CAS  Google Scholar 

  • Smitz J, Devroey P, Bourgain C et al. (1988) Luteal supplementation regimes after combined GnRH-agonist/HMG superovulation. J Reprod Fertil Abstr Ser 2: 18

    Google Scholar 

  • Smitz J, Ron-El R, Tarlatzis BC (1992) The use of gonadotropin releasing hormone agonists for in-vitro fertilization and other assisted procreation techniques. Experience from three centers. Hum Reprod 2: 309–314

    Google Scholar 

  • Stanger JD, Yovich JL (1985) Reduced in-vitro fertilization of human oocytes from patients with raised basal luteinizing hormon levels during the follicular phase.Br J Obstet Gynecol 92: 385–393

    CAS  Google Scholar 

  • Stauber M (1993) Psychosomatik der ungewollten Kinderlosigkeit. BMV, Berlin

    Google Scholar 

  • Steptoe PC, Edwards RG (1978) Birth after reimplantation of a human embryo. Lancet 11: 366

    Article  Google Scholar 

  • Tan SL, Kingsland C, Campbell S (1993) The use of buserelin in in vitro fertilization - a comparison between the long and short protocols of administration. Gynecol Endocrinol 4 [Suppl 21: 107

    Google Scholar 

  • Tanbo T, Dale PO, Kjekhus E, Haug E, Abyholm T (1990) Stimulation with human menopausal gonadotropin versus follicle-stimulating hormone after pituitary suppression in polycystic ovarian syndrome. Fertil Steril 53: 798–803

    PubMed  CAS  Google Scholar 

  • Tartlatzis BC, Pados G, Bontis J, Lagos S, Grimbizis G, Spanos E, Mantalenakis S (1993) Ovarian stimulation with buserelin/HMG/HCG: prospective randomized study of short versus long protocol. Hum Reprod 8: 807–812

    Google Scholar 

  • Trounson AO, Leeton JF, Wood C, Webb J, Wood J (1981) Pregnancies in human by fertiliza- tion in vitro and embryo transfer in the controlled ovulatory cycle. Science 212: 681

    Article  PubMed  CAS  Google Scholar 

  • Van Steirteghem AC, Liu J, Joris H et al. (1993) Higher success rate by intracytoplasmatic sperm injection than by subzonal insemination. Report of a second series of 300 consecutive treatment cycles

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Diedrich, K., Weiss, J.M., Felberbaum, R. (1998). In-vitro-Fertilisation. In: Diedrich, K. (eds) Weibliche Sterilität. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58738-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58738-2_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63704-9

  • Online ISBN: 978-3-642-58738-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics