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Angiotensin on Vascular Smooth Muscle

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Angiotensin

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Abstract

Angiotensin is a potent agonist that causes contraction of vascular smooth muscle. The resultant vasoconstriction in the intact organism has important physiological and pathophysiological implications which are reflected in a number of recent reviews (Peart, 1965; Gross et al., 1968; Somlyo and Somlyo, 1970). These extensive and excellent surveys have lightened my burden. In these reviews and in the recent literature I have covered, credit is given to the pioneer investigations in this already mature field; historical survey is omitted in the current review. Although I have restricted coverage to the past few years, I have found that in this period research has been adequately active to justify an attempt to describe the current state of the art. Contributions dealing with the effect of angiotensin on vascular smooth muscle have been primarily descriptive, yet enough of these bits of information have accumulated and are falling into place so that some mechanistic interpretations now seem appropriate.

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References

  • Aiken, J. W., Vane, J. R.: The renin-angiotensin system: Inhibition of converting enzyme in isolated tissues. Nature (Lond.) 228, 30 (1970).

    Article  CAS  Google Scholar 

  • Alttjra, B. M., Alttjra, B. T.: (1) Differential effects of substrate depletion on drug-induced contractions of rabbit aorta. Amer. J. Physiol. 219, 1698 (1970).

    Google Scholar 

  • Alttjra, B. M., Alttjra, B. T.: (2) Calcium content and force of drug-induced contractions of arterial muscle during recovery in vitro. Proc. Soc. exp. Biol. (N. Y.) 135, 739 (1970).

    Google Scholar 

  • Altura, B. M., Alttjra, B. T.: Influence of magnesium on drug-induced contractions and ion content in rabbit aorta. Amer. J. Physiol. 220, 938 (1971).

    PubMed  CAS  Google Scholar 

  • Arakawa, K., Smeby, B. R., Btjmptjs, F. M.: Synthesis of suecinylMsoleucyl5-angiotensin II and N(poly-O-acetyl-seryl)-isoleucyl5-angiotensin II. J. Amer. chem. Soc. 84, 1424 (1962).

    Article  CAS  Google Scholar 

  • Ayers, A. B., Davies, B. N., Withrington, P. G.: The responses of the isolated perfused spleen of man to sympathetic nerve stimulation, catecholamines, and polypeptides. Brit. J. Pharmacol. 40, 575 P (1970).

    Google Scholar 

  • Baudouin, M., Meyer, P., Worcel, M.: Specific binding of 3H-angiotensin II in rabbit aorta. Biochem. biophys. Res. Commun. 42, 434 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Baudouin, M., Meyer, P., Fermanjian, S., Morgat, J.: Calcium release induced by interaction of angiotensin with its receptors in smooth muscle cell microsomes. Nature 235, 336 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Bergmann, J., Oehme, P., Jelînek, J., Cort, J. H.: Potentiation of angiotensin and eledoisin activities by sodium chloride. Life Sci. 10, 969 (1971).

    Article  CAS  Google Scholar 

  • Blair-West, J. R., Harding, R., McKenzie, J. S.: Effect of sodium concentration on the vasoconstrictor action of angiotensin in the rabbit ear. Europ. J. Pharmacol. 4, 77 (1968).

    Article  CAS  Google Scholar 

  • Bohr, D. F.: Adrenergic receptors in coronary arteries. In: New adrenergic blocking drugs: Their pharmacological, biochemical and clinical actions. Ann. Acad. Sci. (N. Y.) 139, 799 (1967).

    Google Scholar 

  • Bohr, D. F., Uchida, E.: Individualities of vascular smooth muscles in response to angiotensin. Circulât. Res. 20 and 21 (Suppl. II), 11–135 (1967).

    Google Scholar 

  • Brunner, H. R., Chang, P., Wallach, R., Sealey, J. E., Laragh, J. H.: Angiotensin II vascular receptors: Their avidity in relationship to sodium balance, the autonomic nervous system, and hypertension. J. clin. Invest. 51, 58 (1972).

    Article  PubMed  CAS  Google Scholar 

  • Carrier, O., Jr., Shibata, S.: A possible role for tissue calcium in reserpine supersensitivity. J. Pharmacol, exp. Ther. 155, 42 (1967).

    CAS  Google Scholar 

  • Carrière, S., Biron, P.: Effect of angiotensin I on intrarenal blood flow distribution. Amer. J. Physiol. 219, 1642 (1970).

    PubMed  Google Scholar 

  • Carrière, S., Friborg, J.: Intrarenal blood flow and PAH extraction during angiotensin infusion. Amer. J. Physiol. 217, 1708 (1969).

    PubMed  Google Scholar 

  • Chryssanthou, C., Nelson, E., Teichner, F., Antopol, W.: The vasopressor effect of angiotensin in the rat and its inhibition by neotetrazolium. Fed. Proc. 30 (abstract), 450 (1971).

    Google Scholar 

  • Day, M. D., Owen, D. A. A.: The effect of reserpine on the pressor responses to angiotensin in the conscious cat. Brit. J. Pharmacol. 39, 414 (1970).

    CAS  Google Scholar 

  • DiSalvo, J., Fell, C.: Effects of angiotensin on canine renal blood flow. Proc. Soc. exp. Biol. (N. Y.) 133, 1432 (1970).

    CAS  Google Scholar 

  • Drimal, J.: Effects of angiotensin II on coronary smooth muscle. Europ. J. Pharmacol. 5, 56 (1968).

    Article  CAS  Google Scholar 

  • Dyer, D. C.: The pharmacology of isolated sheep umbilical cord blood vessels. J. Pharmacol, exp. Ther. 175, 565 (1970).

    CAS  Google Scholar 

  • Friedman, S. M., Friedman, C. L.: The emerging role of sodium and potassium in the regulation of vascular smooth muscle tension. In: Electrolytes and cardiovascular diseases, ed by E. Bajusz, pp 323–341. Basel: S. Karger 1965.

    Google Scholar 

  • Geller, R. G., Kendrick, J. E.: Flow responses to angiotensin in innervated and denervated kidneys. Proc. Soc. exp. Biol. Med. 129, 727 (1968).

    PubMed  CAS  Google Scholar 

  • Godfraind, T.: Réponse contractile de muscles lisses isolés à des stimulations répétées par Tangiotensine. Arch. int. Pharmacodyn. 176, 464 (1968).

    PubMed  CAS  Google Scholar 

  • Godfraind, T.: Angiotensin auto-potentiation. Brit. J. Pharmacol. 40, 542 (1970).

    Google Scholar 

  • Goodfriend, T. L., Lin, S. Y.: Receptors for angiotensin I and II. Circulât. Res. 26 and 27 (Suppl. I), 1–163 (1970).

    Google Scholar 

  • Gough, E. D., Dyer, D. C.: Responses of isolated human uterine arteries to vasoactive drugs. Amer. J. Obstet. Gynec. 110, 625 (1971).

    PubMed  CAS  Google Scholar 

  • Greenway, C. V., Stark, R. D.: The vascular responses of the spleen to intravenous infusions of catecholamines, angiotensin and vasopressin in the anesthetized cat. Brit. J. Pharmacol. 38, 583 (1970).

    CAS  Google Scholar 

  • Gross, F., Khairallah, P. A., McGiff, J. C.: Pharmacology of angiotensin, ed. by R. D. Bunag. In: Renal hypertension, ed. by I. H. Page and J. W. McCubbin, pp 134–159. Chicago: Year Book Medical Publishers, Inc. 1968.

    Google Scholar 

  • Hedwall, P. R., Abdel-Sayed, W. A., Schmidt, P. G., Abboud, F. M.: Inhibition of veno- constrictor responses by prostaglandin Ex. Proc. Soc. exp. Biol. (N. Y.) 135, 757 (1970).

    CAS  Google Scholar 

  • Hyman, A.: The direct effect of norepinephrine and of angiotensin on the pulmonary veins of intact dogs. J. Pharmacol, exp. Ther. 165, 87 (1969).

    CAS  Google Scholar 

  • Jarhult, J.: Comparative effects of angiotensin and noradrenaline on resistance, capacitance, and precapillary sphincter vessels in cat skeletal muscle. Acta physiol. scand. 81, 315 (1971).

    Article  PubMed  CAS  Google Scholar 

  • Kadowitz, P. J., Sweet, C. S., Brody, M. J.: Potentiation of adrenergic venomotor responses by angiotensin, prostaglandin F2a and cocaine. J. Pharmacol, exp. Ther. 176, 167 (1971).

    CAS  Google Scholar 

  • Kalsner, S., Nickerson, M., Boyd, G. N.: Selective blockade of potassium-induced contractions of aortic strips by β-diethyl-aminoethyl-diphenylpropylacetate (SKF 525A). J. Pharmacol, exp. Ther. 174, 500 (1970).

    CAS  Google Scholar 

  • Keene, J., Seidel, C., Bohr, D. F.: Manganese on calcium flux and norepinephrine-induced tension in arterial smooth muscle. Proc. Soc. exp. Biol. (N. Y.) 139, 1083 (1972).

    CAS  Google Scholar 

  • Khaiballah, P. A., Davila, D., Papanicolaou, N., Glende, N. M., Meyer, P.: Effects of angiotensin infusion on catecholamine uptake and reactivity in blood vessels. Circulat. Res. 28 and 29 (Suppl. II), 11–96 (1971).

    Google Scholar 

  • Khaiballah, P. A., Page, I. H.: Mechanism of action of angiotensin and bradykinin on smooth muscle in situ. Amer. J. Physiol. 200, 51 (1961).

    Google Scholar 

  • Khairallah, P. A., Page, I. H., Bttmpus, P. M., Turker, R. K.: Angiotensin tachyphylaxis and its reversal. Circulat. Res. 19, 247 (1966).

    PubMed  CAS  Google Scholar 

  • Kjran, B. K., Khaiballah, P. A.: Angiotensin and norepinephrine efflux. Europ. J. Pharmacol. 6, 102 (1969).

    Article  Google Scholar 

  • Korner, P. I., Stokes, G. S., White, S. W., Chalmers, J. P.: Role of the autonomic nervous system in the renal vasoconstriction response to hemorrhage in the rabbit. Circulat. Res. 20, 676 (1967).

    PubMed  CAS  Google Scholar 

  • Liebatj, H., Distlee, A., Wolff, H. P.: The noradrenalin releasing effect of angiotensin II in isolated blood vessels. Acta endocr. (Kbh.) 100 (Suppl.), 138 (1965).

    Google Scholar 

  • Lumbers, E. R., Whalen, R. F.: Tachyphylaxis to angiotensin in man. Cardiovasc. Res. 4, 312 (1970).

    Article  PubMed  CAS  Google Scholar 

  • Mazurkiewicz-Kwilecki, I. M.: Antagonistic effects of β-adrenergic blocking agents on responses to adrenaline in vascular smooth muscle. Arch. int. Pharmacodyn. 174, 199 (1968).

    PubMed  CAS  Google Scholar 

  • McNeill, J. R., Stark, R. D., Gbeenway, C. V.: Intestinal vasoconstriction after hemorrhage: roles of vasopressin and angiotensin. Amer. J. Physiol. 219, 1342 (1970).

    PubMed  CAS  Google Scholar 

  • Meyee, P., Papadimitbioij, A., Woecel, M.: Possible existence of different types of angiotensin II receptors. Brit. J. Pharmacol. 40, 541 P (1970).

    Google Scholar 

  • Nissen, O. I., Galskov, A.: Direct measurement of superficial and deep venous flow in the cat kidney. Circulat. Res. 80, 82 (1972).

    Google Scholar 

  • Palaic, D., Lemoevan, P.: Angiotensin tachyphylaxis in guinea-pig aortic strips. J. Pharmacol. exp. Ther. 179, 522 (1971).

    PubMed  CAS  Google Scholar 

  • Pals, D. T., Fitlton, R. W., Masucci, F. D.: Angiotensin, cocaine and desipramine: Comparison of effects on blood pressure responses to norepinephrine, tyramine and phenylephrine in the pithed rat. J. Pharmacol, exp. Ther. 162, 85 (1968).

    CAS  Google Scholar 

  • Panisset, J. C., Bouedois, P.: Effect of angiotensin on the response to noradrenaline and sympathetic nerve stimulation, and on 3H-noradrenaline uptake in cat mesenteric blood vessels. Canad. J. Physiol. Pharmacol. 46, 125 (1968).

    Article  CAS  Google Scholar 

  • Peaut, W. S.: The renin-angiotensin system. Pharmacol. Rev. 17, 143 (1965).

    Google Scholar 

  • Perry, H. M., Jr., Schoepfle, E., Bourgoignie, J.: In vitro production and inhibition of aortic vasoconstriction by mercuric, cadmium, and other metal ions. Proc. Soc. exp. Biol. (N. Y.) 124, 485 (1967).

    CAS  Google Scholar 

  • Popovec, J., Kovilcik, V., Smyk, L., Balskova, I.: Folia. Fac. Med. Univ. Comenianae Bratislav. 6, 205 (1968).

    Google Scholar 

  • Shehadeh, Z., Price, W. E., Jacobson, E. D.: Effects of vasoactive agents on intestinal blood flow and motility in the dog. Amer. J. Physiol. 216, 386 (1969).

    PubMed  CAS  Google Scholar 

  • Sitrin, M. D., Bohr, D. F.: Ca and Na interaction in vascular smooth muscle contraction. Amer. J. Physiol. 220, 1124 (1971).

    PubMed  CAS  Google Scholar 

  • Somlyo, A. P., Somlyo, A. V.: Vascular smooth muscle II. Pharmacology of normal and hypertensive vessels. Pharmacol. Rev. 22, 249 (1970).

    PubMed  CAS  Google Scholar 

  • Somlyo, A. P., Somlyo, A. V.: Electrophysiological correlates of the inequality of maximal vascular smooth muscle contraction elicited by drugs. Proc. Symp. Physiol. Pharmacol. Vascular Neuroeffector Systems, p. 216. Basel: S. Karger 1971.

    Google Scholar 

  • Sparrow, M. P., Maxwell, L. C., Ruegg, J. C., Bohr, D. F.: Preparation and properties of a calcium ion-sensitive actomyosin from arteries. Amer. J. Physiol. 219, 1366 (1970).

    PubMed  CAS  Google Scholar 

  • Stolc, S.: Vztah medzi tonusom mezenterialneho riecista a jeho citlivostou na niektore vazokonstrikcne latky u psa. (Relationship between the tonus of the canine mesenteric vascular bed and its sensitivity to some vasoconstrictor drugs.) Bratislavske lekarske listy 52, 303 (1969).

    PubMed  CAS  Google Scholar 

  • Sullivan, L. J., Briggs, A. H.: Effects of manganese on the response of aortic strips to angiotensin and norepinephrine contraction. J. Pharmacol, exp. Ther. 161, 205 (1968).

    CAS  Google Scholar 

  • Thind, G. S., Peterson, L. H.: Effects of autonomic nervous system blocking (ANSB) agents on angiotensin responses. J. clin. Invest. 47, 96 a (1968).

    Google Scholar 

  • Thind, G. S., Stephan, K. F., Blakemore, W. S.: Vascular responsiveness in cadmium- induced hypertension. Fed. Proc. 28, 329 (1969).

    Google Scholar 

  • Thind, G. S., Stephan, K. F., Blakemore, W. S.: Inhibition of vasopressor responses by cadmium. Amer. J. Physiol. 219, 577 (1970).

    PubMed  CAS  Google Scholar 

  • Tubkee, R. K., Page, I. H., Khairallah, P. A.: Angiotensin alteration of sodium fluxes in smooth muscle. Arch. int. Pharmacodyn. 165, 394 (1967).

    Google Scholar 

  • Van Breemen, C., Farinas, B. R., Gerba, P., McNatjghton, E. D.: Excitation-contraction coupling in rabbit aorta studied by the lanthanum method for measuring cellular calcium influx. Circulat. Res. 30, 44 (1972).

    PubMed  Google Scholar 

  • Villamil, M. F., Nachev, P., Kleeman, C. R.: Effect of prolonged infusion of angiotensin II on ionic composition of the arterial wall. Amer. J. Physiol. 218, 1281 (1970).

    PubMed  CAS  Google Scholar 

  • Voth, D., Agsten, M., Schipp, R., Lübcke, H.: Untersuchungen zur Wirkung von Angiotensin II auf einen autorhythmischen glatten Gefäßmuskel (Pfortader der Ratte). Arch. Kreisl.-Forsch. 65, 41 (1971).

    Article  CAS  Google Scholar 

  • Walter, P., Bassenge, E.: Effect of angiotensin on vascular smooth muscle. Pflügers Arch, ges. Physiol. 307, 70 (1969).

    Article  CAS  Google Scholar 

  • Ward, C. O., Gautieri, R. F.: Effect of certain drugs on perfused human placenta IX: Mode of action of angiotensin. J. Pharmac. Sci. 58, 592 (1969).

    Article  CAS  Google Scholar 

  • Worcel, M., Meyer, P., D’Auriac, G. A., Papanicolaou, N., Mtlliez, P.: The role of angiotensin. Indirect studies with antiangiotensin plasma. Circulat. Res. 26 and 27 (Suppl. II), 11–223 (1970).

    Google Scholar 

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Authors
  1. David F. Bohr
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Editors and Affiliations

  1. The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    Irvine H. Page M.D. (Emeritus Director of Research) (Emeritus Director of Research)

  2. Division of Research, The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    F. Merlin Bumpus Ph.D. (Chairman) (Chairman)

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Bohr, D.F. (1974). Angiotensin on Vascular Smooth Muscle. In: Page, I.H., Bumpus, F.M. (eds) Angiotensin. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65600-2_23

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  • DOI: https://doi.org/10.1007/978-3-642-65600-2_23

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