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Antibodies to Interleukin-2 (IL-2) in Patients: Cross Reactivity with Different IL-2 Species

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Cytokines in Hemopoiesis, Oncology, and AIDS

Abstract

Nautral interleukin-2 (nIL-2) is a polypeptide which is synthesized and secreted in a nonglycosylated as well as in two glycosylated species. The lymphokine regulates growth and differentiation of lymphocytes. It is produced by T lymphocytes upon antigenic or mitogenic stimulation. Most species of recombinant interleukin-2 (rIL-2) differ from nIL-2 by lack of glycosylation and some also in amino acid sequence. The aim of this investigation was to look by immunoblotting for cross reactivities of antibodies to IL-2 with different preparations of human IL-2. The antibodies were found in the sera of five tumor patients after treatment with nonglycosylated rIL-2.

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References

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Authors
  1. H. Mohr
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  2. J. Knüver-Hopf
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  3. J. Atzpodien
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  4. H. Kirchner
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  5. U. Pohl
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Editors and Affiliations

  1. Abt. Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    Mathias Freund  & Hartmut Link  & 

  2. Abt. Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    Karl Welte

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© 1990 Springer-Verlag, Berlin Heidelberg

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Mohr, H., Knüver-Hopf, J., Atzpodien, J., Kirchner, H., Pohl, U. (1990). Antibodies to Interleukin-2 (IL-2) in Patients: Cross Reactivity with Different IL-2 Species. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_95

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  • DOI: https://doi.org/10.1007/978-3-642-75510-1_95

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52281-2

  • Online ISBN: 978-3-642-75510-1

  • eBook Packages: Springer Book Archive

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