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Zellzyklus und Apoptose

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Die Onkologie

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Zusammenfassung

Wesentliches Merkmal maligner Tumoren ist die unkontrollierte Proliferation, bei der die Zellen den normalen Regulationsmechanismen der Gewebshomöostase nicht mehr gehorchen. Die unkontrollierte Proliferation der Tumorzellen ist Folge von Ausfall oder Störung der Moleküle und Signalwege, die Wachstum und Zelltod kontrollieren. In den letzten Jahren sind wichtige Mechanismen der zellulären Wachstumskontrolle entschlüsselt worden: die molekulare Regulation des Zellzyklus, die die Fähigkeit zur Zellteilung bestimmt, und die Signalwege, die den programmierten Zelltod (Apoptose) kontrollieren, ohne den eine koordinierte Entwicklung in multizellulären Organismen nicht möglich ist. Die Regulation von Zellzyklus und Apoptose ist zwar in den Grundzügen verstanden, im Detail handelt es sich dabei jedoch jeweils um äußerst komplexe Regulationsvorgänge mit gegenseitiger Verflechtung und Verknüpfung mit anderen intrazellulären Signalwegen.

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Debatin, KM. (2004). Zellzyklus und Apoptose. In: Die Onkologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-06670-6_6

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