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Chromosome Cohesion and Segregation

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The Molecular Biology of Schizosaccharomyces pombe

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Abstract

Eukaryotic cells have multiple chromosomes as carts for the genetic information. In order to ensure faithful reproduction for proliferation in mitosis, or providing an opportunity for genetic reassortment in meiosis, cells must have the ability to deliver their chromosomes properly and in good order to the daughter cells. Chromosome missegregation leads to aneuploidy, the most common genetic aberrations causing birth defects or cancer. During the cell cycle, therefore, the order and timing of dynamic changes in chromosomal morphology and behavior must be tightly controlled to coincide with the cytoskeletal changes that coordinately participate in the processes of genome redistribution.

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Authors
  1. Kohta Takahashi
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  2. Mitsuhiro Yanagida
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Editors and Affiliations

  1. Department of Genetics, Institute of Molecular Biology, University of Copenhagen, Øster Farimagsgade 2A, 1353, Copenhagen K, Denmark

    Richard Egel

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© 2004 Springer-Verlag Berlin Heidelberg

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Takahashi, K., Yanagida, M. (2004). Chromosome Cohesion and Segregation. In: Egel, R. (eds) The Molecular Biology of Schizosaccharomyces pombe . Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10360-9_11

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  • DOI: https://doi.org/10.1007/978-3-662-10360-9_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-05631-4

  • Online ISBN: 978-3-662-10360-9

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