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Psoriasis

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Braun-Falco´s Dermatology

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Abstract

Psoriasis vulgaris is a common HLA-associated chronic, inflammatory disease of the skin and partly also of the connective tissue in the form of psoriatic arthritis. Psoriasis develops because of a complex genetic predisposition and has a familial occurrence that is often detectable over generations. Psoriasis also occurs without family background and known genetic associations. The skin lesions of psoriasis are sharply defined, silvery-white scaly erythematosquamous plaques in typical distribution. They result from increased inflammatory epidermopoiesis and can cover wide areas of the skin. In addition to the classic skin manifestations such as guttate psoriasis or plaque psoriasis, there are various generalized or localized special forms with or without pustules. A substantial number of psoriasis patients develop seronegative polyarthritis. Diseases frequently associated with psoriasis are inflammatory bowel disease and uveitis. Depending on its duration and severity, psoriasis also involves an independent risk of obesity, metabolic syndrome, cardiovascular disease, and increased mortality. Psoriasis is now considered to be a predominantly T-cell-mediated autoimmune disease in which activation of a certain functional type of autoreactive T cells against skin tissue cells causes chronic inflammation.

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Author information

Authors and Affiliations

  1. Psoriasis Centre, Clinic for Dermatology, Venerology and Allergology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany

    Ulrich Mrowietz

  2. Clinic and Polyclinic for Dermatology, Ludwig-Maximilian-University Munich, Munich, Germany

    Jörg Christoph Prinz

Authors
  1. Ulrich Mrowietz
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  2. Jörg Christoph Prinz
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Correspondence to Ulrich Mrowietz .

Editor information

Editors and Affiliations

  1. Department of Dermatology, Venerology and Allergology, University of Munich, Munich, Germany

    Gerd Plewig

  2. Department of Dermatology, Venerology and Allergology, University of Munich, Munich, Germany

    Lars French

  3. Department of Dermatology, Venerology and Allergology, University of Munich, Munich, Germany

    Thomas Ruzicka

  4. Department of Dermatology, Venerology and Allergology, University of Frankfurt, Frankfurt, Germany

    Roland Kaufmann

  5. Department of Dermatology and Allergology, University of Marburg, Marburg, Germany

    Michael Hertl

Section Editor information

  1. Department of Dermatology, University of Munich, Munich, Germany

    Thomas Ruzicka

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Mrowietz, U., Prinz, J.C. (2022). Psoriasis. In: Plewig, G., French, L., Ruzicka, T., Kaufmann, R., Hertl, M. (eds) Braun-Falco´s Dermatology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-63709-8_39

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  • DOI: https://doi.org/10.1007/978-3-662-63709-8_39

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