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Proteome of Coxiella burnetii

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Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium

Part of the book series: Advances in Experimental Medicine and Biology ((volume 984))

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Abstract

Recent proteomic studies of C. burnetii, the etiological agent of Q fever, have brought a deeper insight into the pathogen’s physiology and offered new possibilities in investigations of inter- or intra-species relatedness. The data generated from these studies in conjunction with the current genomic sequence databases may reveal additional identities for conserved and unique C. burnetii biomarkers and aid in creating algorithms and/or databases that could develop into diagnostic and detection tools for the pathogen. Moreover, wide scale screening and further characterization of potential C. burnetii protein antigens along with a comprehensive evaluation of the humoral immune response will be of fundamental importance towards research and development of a safe and efficacious vaccine as well as improved serodiagnostic tests for rapid and sensitive detection of the Q fever pathogen. Given these advances, proteomics may make marked contributions to the improvement of human health protection against C. burnetii in the coming years.

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Acknowledgement

This research was supported in part by the grant 2/0026/12 from the Scientific Grant Agency of Ministry of Education of Slovak Republic and the Slovak Academy of Sciences.

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Authors and Affiliations

  1. Department of Clinical and Experimental Medicine, Division of Cell Biology, Faculty of Health Sciences, Linköping University, S-581 85, Linköping, Sweden

    Robert Ihnatko

  2. Department of Microbiology and Molecular Genetics, Oklahoma State University, Stillwater, OK, USA

    Edward Shaw

  3. Laboratory for Diagnosis and Prevention of Rickettsial and Chlamydial Infections, Institute of Virology, Slovak Academy of Sciences, Dubravska cesta 9, 845 05, Bratislava, Slovakia

    Rudolf Toman

Authors
  1. Robert Ihnatko
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  2. Edward Shaw
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  3. Rudolf Toman
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Corresponding author

Correspondence to Rudolf Toman .

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Editors and Affiliations

  1. Institute of Virology, Dept. of Rickettsiology, Slovak Academy of Sciences, Dubravska cesta 9, Bratislava, 845 05, Slovakia

    Rudolf Toman

  2. Rocky Mountain Laboratories, Coxiella Pathogenesis Section, NIH/NIAID, South Fourth Street 903, Hamilton, 59840, Montana, USA

    Robert A. Heinzen

  3. , Microbial and Molecular Pathogenesis, College of Medicine, Texas A&M, Joe H. Reynolds Medical Building, College Station 407, College Station, 77843-1114, Texas, USA

    James E. Samuel

  4. Institut Fédératif de Recherche 48, Les Maladies Infect Transmissibles, CNRS-IRD UMR 6236, Bd Jean Moulin 27, Marseille, Cedex 05, 13385, France

    Jean-Louis Mege

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Ihnatko, R., Shaw, E., Toman, R. (2012). Proteome of Coxiella burnetii . In: Toman, R., Heinzen, R., Samuel, J., Mege, JL. (eds) Coxiella burnetii: Recent Advances and New Perspectives in Research of the Q Fever Bacterium. Advances in Experimental Medicine and Biology, vol 984. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4315-1_6

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