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The metabolism of nucleotides

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The Biochemistry of the Nucleic Acids

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Abstract

A supply of ribonucleoside and deoxyribonucleoside 5′-triphosphates is required for the biosynthesis of nucleic acids (see Chapters 6 and 8). The synthesis of these compounds occurs in two main stages: (1) the formation of the purine and pyrimidine ring systems and their conversion to the parent ribonucleoside monophosphate, inosine 5′-monophosphate (IMP) and uridine 5′-monophosphate (UMP); (2) a series of interconversions involving the reduction of ribonucleotides to deoxyribonucleotides and the phosphorylation of these nucleotides to form a balanced set of 5′-triphosphates (Fig. 5.8).

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  1. Department of Biochemistry, University of Glasgow, UK

    Roger L. P. Adams, John T. Knowler & David P. Leader

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Adams, R.L.P., Knowler, J.T., Leader, D.P. (1986). The metabolism of nucleotides. In: The Biochemistry of the Nucleic Acids. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-4103-8_5

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  • DOI: https://doi.org/10.1007/978-94-009-4103-8_5

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