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Antibodies to the Acetylcholine Receptor

  • Chapter
Monoclonal Antibodies to Receptors

Part of the book series: Receptors and Recognition ((SERB,volume 17))

  • 51 Accesses

  • 6 Citations

Abstract

The nicotinic acetylcholine receptor (AChR) is one of the key proteins governing the function of the neuromuscular junction. It is the first neurotransmitter receptor to be identified as a molecular entity and to be isolated and purified in an active form. One advantage of this receptor over other receptor systems is the availability of a rich and convenient source for AChR in electric organs of electric fish (eels or rays). This, in addition to the fact that α-neurotoxins from some Elapid snakes bind specifically and with very high affinity to the AChR, has facilitated and enabled the isolation and purification of this receptor and its thorough analysis.

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Abbreviations

anti-dAChR:

Antibodies to non-structural (or denaturation-resistant) determinants of the acetylcholine receptor

AChR:

Acetylcholine receptor

EAMG:

Experimental autoimmune myasthenia gravis

MG:

Myasthenia gravis

RCM-AChR:

Reduced and carboxymethylated receptor

SDS α-Bgt:

Sodium dodecyl sulfate α-Bungarotoxin, a potent acetylcholine receptor antagonist (and neurotoxin) from snakes

T-AChR:

Trypsin-digested acetylcholine receptor

PA-AChR:

Polyalanyl-derivatized acetylcholine receptor

nit-AChR:

Nitrated acetylcholine receptor

anti-nAChR:

Antibodies to conformational (denaturation-sensitive) or ‘native’ determinants of acetylcholine receptor

Torpedo californica, Electrophorus electricus :

Species of electric fish providing a rich source of acetylcholine receptors ( — from the electroplax organ)

JR:

Junctional acetylcholine receptor (present at high density in adult, mammalian skeletal neuromuscular junctions)

EJR:

Extra junctional acetylcholine receptor (present over the entire surface of embryonic or denervated adult muscle fibres)

Mepp:

Miniature end plate potential

F(ab’)2 :

Pepsin-digested, divalent fragments of antibody

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Authors
  1. Sara Fuchs
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  2. Miry C. Souroujon
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  3. Daria Mochly-Rosen
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Editors and Affiliations

  1. Leukaemia Research Fund Centre, Institute for Cancer Research, London, UK

    M. F. Greaves

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Fuchs, S., Souroujon, M.C., Mochly-Rosen, D. (1984). Antibodies to the Acetylcholine Receptor. In: Greaves, M.F. (eds) Monoclonal Antibodies to Receptors. Receptors and Recognition, vol 17. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5566-0_8

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