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An Introduction to Purinergic Receptors

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Purinergic Receptors

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Abstract

Adenosine 5′-triphosphate (ATP) was primarily considered as an intracellular energy source for many years. However, during the past fifty years purine nucleotides and nucleosides have been shown to have potent extracellular actions on excitable membranes which may be involved in physiological regulatory processes (Berne, 1963; Burnstock, 1972, 1975, 1979; Baer and Drummond, 1979). While knowledge of purinergic receptors is still in its infancy compared to the voluminous work on the classical adrenergic and cholinergic receptors, much progress is being made on their pharmacological characterisation, the ionic basis of their actions and their biochemical identity. The historical aspects of the purinergic receptor field will be briefly summarised below, while details of their distribution, physiological roles and chemistry will be dealt with in the chapters which follow.

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Authors
  1. G. Burnstock
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  2. Christine M. Brown
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  1. Department of Anatomy and Embryology, University College London, UK

    G. Burnstock

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Burnstock, G., Brown, C.M. (1981). An Introduction to Purinergic Receptors. In: Burnstock, G. (eds) Purinergic Receptors. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-5816-6_1

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