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Autophagy, Hyperlipidemia, and Atherosclerosis

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Autophagy: Biology and Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1207))

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Abstract

Autophagy is an evolutionarily conserved process in eukaryotes that processes the turnover of intracellular substances. Atherosclerosis is a disease caused by multiple factors, it mainly occurs on the walls of large and medium blood vessels and atherosclerotic plaques form in the intima of the blood vessels. Hyperlipidemia is considered to be a very dangerous factor leading to cardiovascular and cerebrovascular diseases, especially atherosclerosis. This chapter mainly introduces the key role of autophagy in hyperlipidemia and atherosclerosis, that is, impaired lipophagy affects the degradation of triacylglycerol, cholesterol, etc., leading to hyperlipidemia in atherosclerosis. In patients, excessive levels of autophagy accelerate the rupture of atherosclerotic plaque. This chapter also describes the advances in the treatment of atherosclerosis and hyperlipidemia by targeted autophagy.

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Author information

Authors and Affiliations

  1. School of Life Sciences, Shandong University, Jinan, Shandong Province, China

    Junying Miao, Xiaoling Cui & Jun Zhang

  2. School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong Province, China

    Xiaoling Zang

Authors
  1. Junying Miao
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  2. Xiaoling Zang
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  3. Xiaoling Cui
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  4. Jun Zhang
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Corresponding author

Correspondence to Junying Miao .

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Editors and Affiliations

  1. Liaoning Provincial Center for Clinical Research on Neurological Diseases, The First Affiliated Hospital, Dalian Medical University, Dalian, Liaoning, China

    Weidong Le

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Miao, J., Zang, X., Cui, X., Zhang, J. (2020). Autophagy, Hyperlipidemia, and Atherosclerosis. In: Le, W. (eds) Autophagy: Biology and Diseases. Advances in Experimental Medicine and Biology, vol 1207. Springer, Singapore. https://doi.org/10.1007/978-981-15-4272-5_18

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