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Leishmaniasis in Sri Lanka

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Atlas of Dermatoses in Pigmented Skin

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Abstract

Leishmaniasis was first reported in Sri Lanka in 1904. For decades it was considered an exotic disease. This changed in 1992 with the detection of locally acquired cases of cutaneous leishmaniasis. In 2003, causative organism was identified: Leishmania donovani zymodeme MON-37. Now it is endemic in North Central and Southern provinces with an approximate annual incidence of 2000 cases. In this chapter we illustrate leishmaniasis we see in Sri Lanka, therapeutic responses, and complications during therapy. We also illustrate clinical trends in Sri Lanka and laboratory diagnosis.

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References

  • Al-Hucheimi SN, Sultan BA, Al-Dhalimi MA (2009 Apr) A comparative study of the diagnosis of Old World cutaneous leishmaniasis in Iraq by polymerase chain reaction and microbiologic and histopathologic methods. Int J Dermatol 48(4):404–408. https://doi.org/10.1111/j.1365-4632.2009.03903.x

    Article  CAS  PubMed  Google Scholar 

  • Athukorala DN, Seneviratne JKK, Ihalamulla RL et al (1992) Locally acquired cutaneous leishmaniasis in Sri Lanka. J Trop Med Hyg 95:432–433

    Google Scholar 

  • Castellani A (1904) Leishmania donovani in Ceylon. J Trop Med 10:262

    Google Scholar 

  • Downing C, Tyring S (2016) Parasitic diseases. Rook’s textbook of dermatology, 9th edn. Wiley-Blackwell Science, p 33.41–33.50

    Google Scholar 

  • Ganguly S, Saha P, Chatterjee M et al (2015 Oct) PKDL – a silent parasite pool for transmission of Leishmaniasis in Kala-azar Endemic Areas of Malda District, West Bengal, India. PLoS Negl Trop Dis 9(10), e0004138. https://doi.org/10.1371/journal.pntd.0004138. eCollection 2015

  • Gomes CM, Cesetti MV, de Paula NA et al (2017 Feb) Field validation of SYBR green- and TaqMan-based real-time PCR using biopsy and swab samples to diagnose American Tegumentary Leishmaniasis in an Area Where Leishmania (Viannia) Braziliensis is endemic. J Clin Microbiol 55(2), 526–534. https://doi.org/10.1128/JCM.01954-16. Epub 2016 Dec 7

  • Guimaraez LH, Queiroz A, Silva JA et al. (2016) Atypical manifestations of cutaneous leishmaniasis in a region endemic for Leishmania braziliensis: clinical, immunological and parasitological aspects. PLoS Neglect Trop Dis 10(12), e0005100

    Google Scholar 

  • Gunaratna G, Manamperi A, Böhlken-Fascher S et al (2018 Dec) Evaluation of rapid extraction and isothermal amplification techniques for the detection of Leishmania donovani DNA from skin lesions of suspected cases at the point of need in Sri Lanka. Parasit Vectors. 22;11(1), 665. https://doi.org/10.1186/s13071-018-3238-1

  • Hullangamuwa CS, Ranawaka RR, Kahawita IP et al (2011) Analysis of the pattern of passive case detection of leishmaniasis in two tertiary grade hospitals in Sri Lanka. Sri Lanka J Dermatol 15:16–21

    Google Scholar 

  • Karunaweera ND, Pratlong F, Siriwardane HVYD et al (2003) Cutaneous leishmaniasis is caused by Leishmania donovani zymodeme MON-37. Trans R Soc Trop Med Hyg 97:380–381

    Article  CAS  Google Scholar 

  • Mondal D, Ghosh P, Khan MA et al (2016 May) Mobile suitcase laboratory for rapid detection of Leishmania donovani using recombinase polymerase amplification assay. Parasit Vectors 9(1):281. https://doi.org/10.1186/s13071-016-1572-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pigott DM, Golding N, Messina JP et al. (2014). Global database of leishmaniasis occurrence locations 1960–2012. Scientific Data 30(1), 140036

    Google Scholar 

  • Ranasinghe S, Zhang WW, Wickremasinghe R et al (2012 Nov) Leishmania donovani zymodeme MON-37 isolated from an autochthonous visceral leishmaniasis patient in Sri Lanka. Pathog Glob Health 106(7):421–424. https://doi.org/10.1179/2047773212Y.0000000054

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ranawaka RR, Weerakoon HS, Opathella N et al (2010) Leishmaniasis in North Central Province – Sri Lanka. Three years experiences. Sri Lanka J Dermatol 14:4–8

    Google Scholar 

  • Ranawaka RR, Weerakoon HS (2010 Sep) Randomized, double-blind, comparative clinical trial on the efficacy and safety of intralesional sodium stibogluconate and intralesional 7% hypertonic sodium chloride against cutaneous leishmaniasis caused by L. donovani. J Dermatolog Treat 21(5):286–293

    Article  CAS  Google Scholar 

  • Ranawaka RR, Weerakoon HS, Opathella N (2011) Liquid nitrogen cryotherapy on Leishmaniadonovani cutaneous leishmaniasis. J Dermatol Treatment 22:241–245

    Article  Google Scholar 

  • Ranawaka RR, Abeygunasekara PH, Weerakoon HS (2012) Correlation of clinical, parasitological and histopathological diagnosis of cutaneous leishmaniasis in an endemic region in Sri Lanka. Ceylon Med J 57(4):149–152. https://doi.org/10.4038/cmj.v57i4.5082

    Article  CAS  PubMed  Google Scholar 

  • Ranawaka RR, Weerakoon HS, de Silva SH (2014 Apr) The quality of life of Sri Lankan patients with cutaneous leishmaniasis. Mymensingh Med J 23(2):345–351

    CAS  PubMed  Google Scholar 

  • Ranawaka RR, Weerakoon HS, de Silva SH (2015) Randomized, double-blind, controlled, comparative study on intralesional 10% and 15% hypertonic saline versus intralesional sodium stibogluconate in Leishmania donovani cutaneous leishmaniasis. Int J Dermatol 54(5):555–563

    Article  CAS  Google Scholar 

  • Rathnayake D, Ranawake RR, Sirimanna G et al (2010 May) Co-infection of mucosal leishmaniasis and extra-pulmonary tuberculosis in a patient with inherent immune deficiency. Int J Dermatol 49(5):549–551

    Article  Google Scholar 

  • Refai WF, Madarasingha NP, Sumanasena B et al (2017 Oct). Efficacy, safety and cost-effectiveness of thermotherapy in the treatment of Leishmania donovani-induced cutaneous leishmaniasis: a randomized controlled clinical trial. Am J Trop Med Hyg 97(4):1120–1126. https://doi.org/10.4269/ajtmh.16-0879. Epub 2017 Aug 18

  • Rogers WO, Wirth DF (1987) Kinetoplast DNA minicircles: regions of extensive sequence divergence. Proc Natl Acad Sci USA 84:565–569

    Article  CAS  Google Scholar 

  • Semage SN, Pathirana KP, Agampodi SB (2014) Cutaneous leishmaniasis in Mullaitivu, Sri Lanka: a missing endemic district in the leishmaniasis surveillance system. Int J Infect Dis 25:53–55

    Article  CAS  Google Scholar 

  • Senevirathne JK, Siriwardena S, Rathnathunge N et al (1995) Locally acquired leishmaniasis from Central Sri Lanka: a case report. Kandy Med J 4(2):54–56

    Google Scholar 

  • Shirian S, Oryan A, Hatam GR et al (2014) Comparison of conventional, molecular, and immune-histochemical methods in diagnosis of typical and atypical cutaneous leishmaniasis. Arch Pathol Lab Med 138(2):235–240

    Article  CAS  Google Scholar 

  • Siriwardana HVYD, Udagedara C, Karunaweera ND (2003) Study on clinical patterns, risk factors and efficacy of cryotherapy in cutaneous leishmaniasis in Sri Lanka. Ceylon Med J 48(1):10–12

    Article  Google Scholar 

  • Siriwardana HV, Noyes HA, Beeching NJ et al (2007) Leishmania donovani and cutaneous leishmaniasis, Sri Lanka. Emerg Infect Dis 13(3):476–478

    Article  Google Scholar 

  • Siriwardana HVYD (2009) PhD thesis: Study on the clinical epidemiology of cutaneous leishmaniasis in Sri Lanka and molecular identification of the parasite. University of Colombo

    Google Scholar 

  • Siriwardana HVYD, Senarath U, Chandrawansa PH et al (2015) Use of a clinical tool for screening and diagnosis of cutaneous leishmaniasis in Sri Lanka. Pathogens Global Health 109(4):174–183

    Article  CAS  Google Scholar 

  • Siriwardana HVYD, Zhou G, Deepachandi B et al. (2019a) Trends in recently emerged L. donovani induced cutaneous leishmaniasis, Sri Lanka, for first 13 years. Biol Med Res Int 4093603

    Google Scholar 

  • Siriwardana HVYD, Deepachandi B, Gunasekara C et al (2019b) Leishmania donovani induced cutaneous leishmaniasis: an insight into atypical clinical variants in Sri Lanka. J Trop Med 2019, 4538597

    Google Scholar 

  • Siriwardana HVYD, Deepachandi B, Weliange S et al (2019c) First evidence for two independent and different leishmaniasis transmission foci in Sri Lanka. Recent introduction or long-term existence? J Trop Med 2019, 6475939, 11 pages

    Google Scholar 

  • Somaratne VN, Ranawaka RR, Jayaruwan HM et al (2018 Jun) Randomized, double-blind study on intralesional metronidazole versus intralesional sodium stibogluconate in Leishmania donovani cutaneous leishmaniasis. J Dermatolog Treat 7:1–5. https://doi.org/10.1080/09546634.2018.1472738

    Article  CAS  Google Scholar 

  • WHO (2010) Control of the leishmaniasis. World Health OrganizationTechnical report series 949

    Google Scholar 

  • WHO (2017) Manual on case management and surveillance of the leishmaniasis in the WHO European region. http://www.who.int/leishmaniasis/resources/EURO_WHO_Leish_manual_on_case_management_and_surveillance_9789289052511_2017.pdf?ua=1. Accessed on 15 Jan 2019

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Authors and Affiliations

  1. General Hospital Kalutara, Kalutara, Sri Lanka

    Ranthilaka R. Ranawaka

  2. Department of Parasitology, Parasitic Disease Research Unit, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka

    Yamuna Siriwardana

  3. Department of Parasitology, Faculty of Medical Sciences, University of Sri Jayewardenepura, Nugegoda, Sri Lanka

    Shalindra Ranasinghe

Authors
  1. Ranthilaka R. Ranawaka
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  2. Yamuna Siriwardana
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  3. Shalindra Ranasinghe
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Corresponding author

Correspondence to Ranthilaka R. Ranawaka .

Editor information

Editors and Affiliations

  1. Consultant Dermatologist, General Hospital Kalutara, Kalutara, Sri Lanka

    Ranthilaka R. Ranawaka

  2. Consultant Dermatologist, Base Hospital Balapitiya, Balapitiya, Sri Lanka

    Ajith P. Kannangara

  3. Consultant Venereologist, Teaching Hospital Anuradhapura, Anuradhapura, Sri Lanka

    Ajith Karawita

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Ranawaka, R.R., Siriwardana, Y., Ranasinghe, S. (2021). Leishmaniasis in Sri Lanka. In: Ranawaka, R.R., Kannangara, A.P., Karawita, A. (eds) Atlas of Dermatoses in Pigmented Skin. Springer, Singapore. https://doi.org/10.1007/978-981-15-5483-4_21

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  • DOI: https://doi.org/10.1007/978-981-15-5483-4_21

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