Skip to main content

Advertisement

Springer Nature Link
Log in

Use of the oxygen cost of breathing as an index of weaning ability from mechanical ventilation

  • Original Articles
  • Published:
Intensive Care Medicine Aims and scope Submit manuscript

Abstract

The oxygen cost of breathing (which is the difference in oxygen consumption measured during controlled ventilation and again during spontaneous ventilation) was measured in 30 patients between the ages of 17 and 96 years at the time of commencement of weaning from mechanical ventilation. There was a significant exponential correlation between the oxygen cost of breathing in ml/m2/min and the oxygen cost of breathing as a percentage of total oxygen consumption during spontaneous ventilation \((OCB/\dot V_{O_2 } SV\% )\) and the duration of weaning in days.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  1. Millbern SM, Downs JB, Jumper LC, Modell JH (1978) Evaluation of criteria for discontinuing mechanical ventilatory support. Arch Surg 113:1441

    CAS  PubMed  Google Scholar 

  2. Morganroth ML, Morganorth JL, Nett LM, Petty TL (1984) Criteria for weaning from prolonged mechanical ventilation. Arch Intern Med 144:1012

    Article  CAS  PubMed  Google Scholar 

  3. Nishimura M, Taenaka N, Takezawa J, Nobunaga R, Hirata T, Shimata Y, Yoshiya I (1984) Oxygen cost of breathing and the inspiratory work of the ventilator as a weaning monitor in the critically ill. Crit Care Med 12:258

    Google Scholar 

  4. Stewart S, Baker J, Jeejeebhoy KN (1981) Energy expenditure in the critically ill ventilated patient. JPEN 5:562

    Google Scholar 

  5. Roulet M, Detsky AS, Marliss EB, Todd TR, Mahon WA, Anderson GH, Stewart S, Jeejeebhoy KN (1983) A controlled trial of the effect of parenteral nutritional support on patients with respiratory failure and sepsis. Clin Nutr 2:97

    Google Scholar 

  6. Johnson RE (1980) Technique for measuring gas exchange. In: Kinney J (ed) Assessment of energy metabolism in health and disease. Report of the First Ross Conference on Medical Research. Ross Laboratories Colombus Ohio, pp. 32–36

    Google Scholar 

  7. Field S, Kelly SM, Macklem PT (1982) Oxygen cost of breathing in patients with respiratory disease. Am Rev Respir Dis 126:9

    CAS  PubMed  Google Scholar 

  8. Hodgkin JE, Bowser MA, Burton GG (1974) Respirator weaning. Crit Care Med 2:96

    CAS  PubMed  Google Scholar 

  9. Sahn SA, Lakshminarayan S, Petty TL (1976) Weaning from mechanical ventilation. JAMA 235:2208

    CAS  PubMed  Google Scholar 

  10. Skillman JJ, Malhotra IL, Pallotta JA, Bushnell LS (1971) Determinants of weaning from controlled ventilation. Surg Forum 22:198

    CAS  PubMed  Google Scholar 

  11. Tahvanamen J, Salmempera M, Nikki P (1983) Extubation criteria after weaning from intermittent mandatory ventilation and continuous positive airway pressure. Crit Care Med 11:702

    Google Scholar 

  12. Cohen CA, Zagelbaum G, Gross D, Roussos C, Macklem PT (1982) Clinical manifestations of respiratory muscle fatigue. Am J Med 73:308

    Article  CAS  PubMed  Google Scholar 

  13. Macklem PT, Roussos CS. Respiratory muscle fatigue: a cause of respiratory failure. Clin Sci 53:419

  14. Chiang H, Portoppidan H, Wilson S, Browne DRG, Katz A (1973) Respiratory muscle discoordination following prolonged mechanical ventilation. Abstracts of Annual Meeting of the American Society of Anaesthesiologists. San Francisco, p 211

  15. Halmagyi DFJ, Kinney JM (1975) Metabolic rate in acute respiratory failure complicating sepsis. Surgery 77:492

    CAS  PubMed  Google Scholar 

  16. Askanazi J, Weissman C, Rosenbaum SH, Hyman AI, Milie-Emili J, Kinney JM, (1982) Nutrition and the respiratory system. Crit Care Med 10:163

    CAS  PubMed  Google Scholar 

  17. Driver AG, Lebrun M (1980) Iatrogenic malnutrition in patients receiving ventilatory support. JAMA 244:2195

    Article  CAS  PubMed  Google Scholar 

  18. Grossman GD (1973) Factors influencing the response to withdrawal from mechanical ventilation. Postgrad Med 54:165

    CAS  PubMed  Google Scholar 

  19. Browne DR (1984) Weaning patients from mechanical ventilation. Intensive Care Med 10:55

    Article  CAS  PubMed  Google Scholar 

  20. Askanazi J, Rosenbaum SH, Hyman AI, Silverberg PA, Milie-Emili J, Kinney JM (1980) Respiratory changes induced by the large glucose loads of total parenteral nutrition. JAMA 243:1444

    Article  CAS  PubMed  Google Scholar 

  21. Askanazi J, Norderstrom J, Rosenbaum SH, Elwyn DH, Hyman AI, Carpenter YA, Kinney JM (1981) Nutrition for the patient with respiratory failure: glucose vs fat. Anesthesiology 54:373

    CAS  PubMed  Google Scholar 

  22. Cherniack RM (1958) The oxygen consumption and efficiency of the respiratory muscles in health and emphysema. J Clin Invest 38:494

    Google Scholar 

  23. McIllroy MB, Christie RV (1954) The work of breathing in emphysema. Clin Sci 13:147

    Google Scholar 

  24. Wilson RS, Sullivan SF, Malm JR, Bowman FD (1973) The oxygen cost of breathing following anesthesia and cardiac surgery. Anesthesiology 39:387

    CAS  PubMed  Google Scholar 

  25. Bursztein S, Taitelman V, de Myttenaere S, Michelson M, Dahan E, Gepstein R, Edelman D, Melamed Y (1978) Reduced oxygen consumption in catabolic states with mechanical ventilation. Crit Care Med 6:162

    CAS  PubMed  Google Scholar 

  26. Henry WC, West GA, Wilson RS (1983) A comparison of the oxygen cost of breathing between a continuous flow CPAP system and a demand flow CPAP system. Resp Care 28:1273

    CAS  Google Scholar 

  27. Gibney RT, Wilson RS, Pontoppidian H (1982) Comparison of work of breathing on high gas flow and demand valve continuous positive airway pressure systems. Chest 83:692

    Google Scholar 

  28. Christopher KL, Neff TA, Eberle DJ, Good JT (1985) Demand and continuous flow intermittent mandatory ventilation systems. Chest 87:625

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anaesthesia/Intensive Care, Toronto Western Hospital, Toronto, Canada

    N. J. McDonald, P. Lavelle, W. N. Gallacher & R. P. Harpin

  2. Department of Anaesthesia, Galway Regional Hospital, Galway, Ireland

    N. J. McDonald

Authors
  1. N. J. McDonald
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. P. Lavelle
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. W. N. Gallacher
    View author publications

    You can also search for this author inPubMed Google Scholar

  4. R. P. Harpin
    View author publications

    You can also search for this author inPubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

McDonald, N.J., Lavelle, P., Gallacher, W.N. et al. Use of the oxygen cost of breathing as an index of weaning ability from mechanical ventilation. Intensive Care Med 14, 50–54 (1988). https://doi.org/10.1007/BF00254122

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00254122

Key words