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AB0 blood group incompatibility and inbreeding effects: Evidence for an interaction

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Summary

It is known that consanguinity reduces the chances of maternal-foetal incompatibility but it is not known whether inbreeding influences the expression of the effects of such incompatibility. This paper investigates and finds evidence for an interaction between inbreeding and AB0 blood group incompatibility on the expression of neonatal mortality, sibship precocious mortality, neonatal jaundice, asphyxia, and sex ratio, through screening of 3923 consecutive newborns. Inbreeding and incompatibility individually showed variable effects on the above parameters, but their interaction was such that, in the presence of inbreeding, incompatibility reduced the incidence/relative risk of all the above factors. Such a uniform negative interaction was presumed to be due to homozygosity of some pleiotropic genes caused by inbreeding.

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References

  • Ansari NA, Sinha SP (1978) Survey of the effects of inbreeding in two populations of Bihar. Indian J Med Res 68:295–299

    Google Scholar 

  • Banarjee AR, Chatterjee D, Roy SK (1963) A preliminary note on mother-child combination of AB0 and Rh(D) blood groups from Calcutta. J Indian Ped Soc 2:13–15

    Google Scholar 

  • Banajee AR, Banajee DK, Roy A (1975) Mother-child combination of AB0 and Rh blood groups and its relation to secondary sexratio. II. Annual Conference of the Indian Society of Human Genetics, Calcutta, November, 1975.

  • Barua S (1978) A study on the effects of AB0 blood group incompatible matings on certain demographic variables based on a sample of Muslim population of 24-Parganas, West Bengal, Symposium on Genetical Demography, Anthropological Survey of India, Calcutta, January, 1978.

  • Chakraborty R, Chakravarti A (1971) On consanguineous marriages and the genetic load. Hum Genet 36:47–54

    Google Scholar 

  • Chakravartti MR, Chakravartti R (1977a) A study on selection in AB0 blood groups. Indian J Phys Anthropol Hum Genet 3:1–12

    Google Scholar 

  • Chakravartti MR, Chakravartti R (1977b) Mother-child incompatibility in the AB0 system. Curr Sci 46:602–603

    Google Scholar 

  • Chakravartti MR, Chakravartti R (1977c) Genetic bearing on the sex ratio. Indian Anthropol 1:56–61

    Google Scholar 

  • Cohen BH (1970) AB0 and Rh incompatibility I. Fetal neonatal mortality with AB0 and Rh incompatibility. Some new interpretations. Am J Hum Genet 22:412–452

    Google Scholar 

  • Freire-Maia N, Krieger H, Barrai I (1971) The capacity of B/A to discriminate genetic loads. Genetique et population (Homage à Jean Sutter). Presses Univ de France, Paris

    Google Scholar 

  • Gupta SC, Bhatia HM (1973) Studies on neonatal jaudice. A role of AB0 incompatible pregnancy. Indian J Med Res 61:1135–1145

    Google Scholar 

  • Haldane JBS (1956) The estimation and significance of the logarithm of a ratio of frequencies. Ann Hum Genet 20:309–311

    Google Scholar 

  • Kumar S, Pai RA, Swaminathan MS (1967) Consanguineous marriages and the genetic load due to lethal genes in Kerala. Ann Hum Genet 31:141–145

    Google Scholar 

  • Malathi Jadhav, Devarajan LV (1972) AB0 hemolytic disease: an important cause of neonatal morbidity. Indian Pediat 9:246–251

    Google Scholar 

  • Matsunaga E, Itoh S (1958) Blood group and fertility in a Japanese population with special reference to intra-uterine selection due to maternal fetal incompability. Ann Hum Genet 22:111–131

    Google Scholar 

  • Morton NE, Crow JF, Muller HJ (1956) An estimate of the mutational damage in man from data on consanguineous marriages. Proc Natl Acad Sci USA 42:855–863

    Google Scholar 

  • Murty JS, Jamil T (1972) Inbreeding load in the newborn of Hyderabad. Acta Genet Med Gamellol (Roma) 21:327–331

    Google Scholar 

  • Murty JS, Rajyalaxmi T (1971) A study of AB0 and other gene frequencies in twin cities of Hyderabad and Secunderabad. Proceedings of the International Symposium on Human Genetics, Andhra University, Waltair (1971)

  • Rao PSSS Inbaraj SJ (1977) Inbreeding effects on human reproduction in Tamil Nadu of South India. Ann Hum Genet 41:87–98

    Google Scholar 

  • Reed TE (1968) Research on blood groups and selection from the child health and development studies: Oakland, California. III. Couple mating type and reproductive performance. Am J Hum Genet 20:129–141

    Google Scholar 

  • Renuka Nair R, Murty JS (1979) Maternal-fetal AB0 incompatibility and secondary sex ratio. Acta Anthropogenet 3:19–28

    Google Scholar 

  • Renuka Nair R, Murty JS, Rao MN, Seetha T (1979) Preclampsia, neonatal asphyxia and AB0 blood group incompability. Indian J Med Res 69:609–615

    Google Scholar 

  • Renuka Nair R, Murty JS, Rao MN, Seetha T (1980) AB0 incompatibility and neonatal jaundice. Indian J Med Res 71:567–575

    Google Scholar 

  • Sahu PN (1977) AB0 blood groups, incompatible matting and fertility in a human breeding isolate. Man In India 57:81–87

    Google Scholar 

  • Smith CAB (1967) Note on paper by Kumar et al. (1967). Corrigenda. Ann Hum Genet 32:419

    Google Scholar 

  • Sokal RP, Rohlf FJC (1969) The principles and practice of statistics in biological research. WH Freeman and Co, San Francisco

    Google Scholar 

  • Woolf B (1955) On estimating the relation between blood groups and diseases. Ann Hum Genet 19:251–253

    Google Scholar 

Download references

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Author notes

  1. R. Renuka Nair

    Present address: Sri chitra Tirunal Institute of Medical Sciences and Technology, 695011, Trivandrum, India

Authors and Affiliations

  1. Department of Genetics, Osmania University, 500007, Hyderabad, India

    R. Renuka Nair & J. S. Murty

Authors
  1. R. Renuka Nair
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  2. J. S. Murty
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Nair, R.R., Murty, J.S. AB0 blood group incompatibility and inbreeding effects: Evidence for an interaction. Hum Genet 69, 147–150 (1985). https://doi.org/10.1007/BF00293286

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  • DOI: https://doi.org/10.1007/BF00293286

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