Abstract
The morphine blocking and anticonvulsant effects of propranolol were investigated in mice. Three different convulsant procedures (electroshock, pentylenetetrazol and thebaine) were used. In addition, LD50's of morphine after different doses of propranolol were done. Sotalol was used as a control drug to check which of the effects of propranolol could be regarded as due to beta blockade.
Morphine LD50 in mice is not altered by pretreatment with propranolol. The anticonvulsant characteristics of propranolol are different from those of sotalol, the former acting mainly on the tonic phase of the seizures. This study does not support the hypothesis that propranolol is a morphine antagonist but reinforces the idea that propranolol has definite central nervous system effects.
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Atsmon, A., Blum, I., Steiner, M., Wijsenbeck, H.: Further studies with propranolol in psychotic patients. Psychopharmacologia (Berl.) 27, 249–254 (1972)
Estler, C. J., Ammon, H. P. T.: Absence of central nervous system effect of practalol (ICI 50, 172; 4-(2-hydroxy-3-isopropylamino propoxy)-acetanilide), a new adrenergic β-receptor blocking drug. J. Pharm. Pharmacol. 21, 554–555 (1969)
Grosz, H. J.: Successful treatment of a heroin addict with propranolol: Implications for opiate addiction treatment and research. J. Indiana State med. Ass. 65, 505–509 (1972a)
Grosz, H. J.: Narcotic withdrawal symptoms in heroin users treated with propranolol. Lancet 1972b II, 564–566
Grosz, H. J.: Effect of propranolol on active users of heroin. Lancet 1973 II, 612
Kelliher, G. L., Buckley, J. P.: Central hypotensive activity of dl and d-propranolol. J. pharm. Sci. 59, 1276–1280 (1970)
Kellner, R., Collins, C., Shulman, R. S., Pathak, D.: The shortterm antianxiety effects of propranolol HCl. J. clin. Pharmacol. 14, 301–304 (1974)
Leszkovsky, G., Tardos, L.: Some effects of propranolol on the central nervous system. J. Pharm. Pharmacol. 17, 518–520 (1965)
Lish, P. M., Weikel, J. H., Dungan, K. W.: Pharmacological and toxicological properties of two new β-adrenergic receptor antagonists. J. Pharmacol. exp. Ther. 149, 161–173 (1965)
Litchfield, J. T., Jr., Wilcoxon, F.: A simplified method of evaluating dose-response experiments. J. Pharmacol. exp. Ther. 96, 99–113 (1949)
Millichap, J. G.: Anticonvulsant drugs. In: Physiological pharmacology, Vol. II, W. S. Root and F. H. Hofmann, eds., pp. 97–172. New York-London: Academic Press 1965
Murmann, W., Almirante, L., Saccani-Guelfi, M.: Central nervous system effects of four β-adrenergic receptor blocking agents. J. Pharm. Pharmacol. 18, 317–318 (1966a)
Murmann, W., Almirante, L., Saccani-Guelfi, M.: Effects of hexobarbitone, ether, morphine and urethane upon the acute toxicity of propranolol and D-(-)-INPEA. J. Pharm. Pharmacol. 18, 692–694 (1966b)
Orzack, M. H., Branconnier, R.: CNS effects of propranolol in man. Psychopharmacologia (Berl.) 29, 299–306 (1973)
Swinyard, E. A.: Laboratory evaluation of antiepileptic drugs. Epilepsia 10, 107–119 (1969)
Toman, J. E. P., Everett, G. M.: Anticonvulsants. In: Evaluation of drug activities. Pharmacometrics, Vol. I, D. R. Lawrence and A. L. Bacharach, eds., pp. 287–300. London-New York: Academic Press 1964
Wheatley, D.: Comparative effects of propranolol and chlordiazepoxide in anxiety states. Brit. J. Psychol. 115, 1411–1412 (1969)
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Navarro, G., Richardson, R. & Zuban, A.T. Propranolol and morphine. Psychopharmacology 51, 39–42 (1976). https://doi.org/10.1007/BF00426318
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DOI: https://doi.org/10.1007/BF00426318