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The biochemistry of synaptic transmission

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Conclusions

Subcellular fractionation techniques have added a new dimension to studies of synaptic function. Much of the research of the past decade has been devoted to improving techniques — for subcellular fractionation techniques are full of pitfalls if applied uncritically and there are many problems concerned with the homogeneity and purity of the fractions. In the next few years rapid progress can be expected in our understanding of the molecular mechanisms involved in transmitter storage and release and the way in which drugs and toxins interfere with these mechanisms. Combined electrophysiological, morphological and biochemical studies of the type now being carried out on theTorpedo will be particularly useful in such research.

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Literatur

  1. Black, D. A. K.: Biochemical Research in Psychiatry: Report by a Committee of the Medical Research Council. London: HMSO 1970.

    Google Scholar 

  2. Bennett, M. V. L., in: Structure and Function of Synapses (G. D. Pappas and D. P. Purpura, eds.), p. 221. New York: Raven Press 1972.

    Google Scholar 

  3. For historical review see Whittaker, V. P.: Prog. Biophys. Mol. Biol.15, 39 (1965).

    Google Scholar 

  4. Whittaker, V. P., et al.: Biochem. J.90, 293 (1964).

    Google Scholar 

  5. Gray, E. G., Whittaker, V. P.: J. Anat. Lond.96, 79 (1962).

    Google Scholar 

  6. Belleroche, J. S. de, Bradford, H.: J. Neurochem.19, 1817 (1972).

    Google Scholar 

  7. Azcurra, J. M., Robertis, E. de: Intern. J. Neuropharmacol.6, 15 (1967).

    Google Scholar 

  8. Barondes, S. H.: J. Neurochem.15, 343 (1968).

    Google Scholar 

  9. Herschman, H., in: Proteins of the Nervons System (ed. D. Schneider). New York: Raven Press (in press).

  10. Keen, P., White, T. D.: J. Neurochem.17, 565 (1970).

    Google Scholar 

  11. Keen, P., White, T. D.: J. Neurochem.18, 1097 (1971).

    Google Scholar 

  12. Fonnum, F.: Biochem. J.103, 262 (1967).

    Google Scholar 

  13. Johnson, M. K., Whittaker, V. P.: ibid.88, 404 (1963).

    Google Scholar 

  14. Marchbanks, R. M.: ibid.104, 148 (1967).

    Google Scholar 

  15. Jones, D. G., in: The Structure and Function of Nervous Tissue (G. Bourne, ed.), vol. 6, p. 81. New York: Academic Press 1972.

    Google Scholar 

  16. Ross, L. L.: personal communication.

  17. Fuxe, K., et al.: Brain Res.6, 475 (1967).

    Google Scholar 

  18. Iversen, L. L., Bloom, F. E.: ibid.41, 131 (1972).

    Google Scholar 

  19. Whittaker, V. P., in: Handbook of Neurochemistry (A. Lajtha, ed.), vol. 2, p. 327. New York: Plenum Press 1969.

    Google Scholar 

  20. Ross, L. L., et al.: Brain Res.25, 103 (1971).

    Google Scholar 

  21. Israël, M., Whittaker, V. P.: Experientia21, 325 (1965).

    Google Scholar 

  22. Lemkey-Johnson, M., Larramendi, L. M. H.: Exp. Brain Res.5, 325 (1968).

    Google Scholar 

  23. Cerro, M. P. del, et al.: ibid.8, 311 (1969).

    Google Scholar 

  24. Balázs, R.,et al.: Biochem. J.128, 81 P (1972).

  25. Krnjević, K., Whittaker, V. P.: J. Physiol.179, 298 (1965).

    Google Scholar 

  26. Whittaker, V. P.: Biochem. J.106, 412 (1968).

    Google Scholar 

  27. Bachelard, H. S.: personal communication.

  28. Marchbanks, R. M., Whittaker, V. P.: Proc. Internat. Meet. Internat. Soc. Neurochem (1st), Strasbourg, p. 147 (1967).

  29. Bradford, H. F.: J. Neurochem.16, 675 (1969).

    Google Scholar 

  30. Peterson, N. A., Raghupathy, E.: ibid.19, 1423, (1972).

    Google Scholar 

  31. Navon, S., Lajtha, A.: Biochim. Biophys. Acta173, 518 (1969).

    Google Scholar 

  32. Bennett, J. P., et al.: Science, N.Y.178, 997 (1972).

    Google Scholar 

  33. Weinstein, H., et al.: Biochem. Pharmacol.14, 273 (1965).

    Google Scholar 

  34. Kuriyama, K., et al.: Brain Res.16, 479, (1969).

    Google Scholar 

  35. Appel, S. H., et al.: J. Biol. Chem.244, 3166 (1969).

    Google Scholar 

  36. Grahame-Smith, D. G., Parfitt, A. G.: J. Neurochem.17, 1339 (1970).

    Google Scholar 

  37. Marchbanks, R. M.: Biochem. J.110, 533 (1968).

    Google Scholar 

  38. Diamond, I., Kennedy, E. P.: J. Biol. Chem.244, 3258 (1969).

    Google Scholar 

  39. Potter, L. T., in: The Interaction of Drugs and Subcellular Components (ed. P. N. Campbell), p. 293. London: J. & A. Churchill 1968.

    Google Scholar 

  40. Yamamura, H., Snyder, S.H.: Science, N. Y.178, 626 (1972).

    Google Scholar 

  41. Dowdall, M. J., Simon, E.: J. Neurochem. (in press).

  42. Whittaker, V. P.: Biochem. J.128, 73P (1972).

  43. Bogdanski, D. F., et al.: Biochim. Biophys. Acta211, 521, (1970).

    Google Scholar 

  44. White, T. D., Keen, P.: ibid.196, 285 (1970).

    Google Scholar 

  45. Colburn, R. W., et al.: Biochem. Pharmacol.17, 957 (1968).

    Google Scholar 

  46. Escuela, A. V., Appel, S. H.: Biochemistry8, 725 (1969).

    Google Scholar 

  47. Blaustein, M. P., et al.: Proc. Nat. Acad. Sci. U.S.A.69, 2237 (1972).

    Google Scholar 

  48. Whittaker, V. P., et al.: Biochem. Soc. Symp.36, 49 (1972).

    Google Scholar 

  49. Kuhar, M. J., et al.: J. Neurochem.20, 581 (1973).

    Google Scholar 

  50. Ling, C.-M., Abdel-Latif, A. A.: ibid.15, 721 (1968).

    Google Scholar 

  51. Haga, T.: ibid.18, 781 (1971).

    Google Scholar 

  52. Bradford, H. S.: Brain Res.19, 239 (1970).

    Google Scholar 

  53. Belleroche, J. S. de, Bradford, H. S.: J. Neurochem.19, 585 (1972).

    Google Scholar 

  54. Edwardson, J. A.et al.: Nature240, 554 (1972)

    Google Scholar 

  55. Douglas, W. W.: Brit. J. Pharmacol.34, 451 (1968).

    Google Scholar 

  56. Diamond, I., Fishman, R. A.: Nature242, 122 (1973).

    Google Scholar 

  57. Clark, A. W.,et al.: J. Cell Biol.52, 1 (1972).

    Google Scholar 

  58. Cull-Candy, S. G.,et al.: Nature251, 353 (1973).

    Google Scholar 

  59. Miller, E. K., Dawson, R. M. C.: Biochem. J.126, 805 (1972).

    Google Scholar 

  60. Morgan, I. G.: FEBS Letters10, 273 (1970).

    Google Scholar 

  61. Giambetti, P.,et al.: J. Cell Biol.52, 526 (1972).

    Google Scholar 

  62. Hernandez-Garcia, A.: PhD Dissertation, U. K. Council for National Academic Awards (1972) and personal communication.

  63. Droz, B., Barondes, S. H.: Science165, 1131 (1969).

    Google Scholar 

  64. Morgan, I. G., Austin, L.: J. Neurochem.15, 41 (1958); Austin, L.: personal communication.

    Google Scholar 

  65. Autilio, A. L.,et al.: Biochemistry7, 2615 (1968).

    Google Scholar 

  66. Whittaker, V. P., Sheridan, M. H.: J. Neurochem.12, 363 (1965).

    Google Scholar 

  67. Whittaker, V. P., in Structure and Function of Synapses (eds. G. D. Pappas and D. P. Purpura), p. 87. New York: Raven Press 1972.

    Google Scholar 

  68. Morgan, I. G.: Biochim. Biophys. Acta241, 737 (1971).

    Google Scholar 

  69. Breckenridge, W. C.,et al.:ibid.266, 695 (1972).

    Google Scholar 

  70. Whittaker, V. P.: Ann. N. Y. Acad. Sci.137, 982 (1966).

    Google Scholar 

  71. Hosie, R. J. A.: Biochem. J.96, 404 (1965).

    Google Scholar 

  72. Harwood, J. L., Hawthorne, J. N.: J. Neurochem.16, 1377 (1969).

    Google Scholar 

  73. Salganicoff, L., Koeppe, R. E.: J. Biol. Chem.243, 3416 (1968).

    Google Scholar 

  74. Blokhuis, G. G. D., Veldstra, H.: FEBS Letters11, 197 (1970).

    Google Scholar 

  75. Fonnum, F.: Biochem. J.106, 401 (1968).

    Google Scholar 

  76. Bogdanski, D. F.,et al.: Neurochem.1, 272 (1957).

    Google Scholar 

  77. Laverty, R.,et al.: Brit. J. Pharmacol.21, 482 (1963).

    Google Scholar 

  78. Michaelson, I. A.:et al.: Biochem. Pharmacol.12, 1450 (1963).

    Google Scholar 

  79. Katz, B., Miledi, R.: J. Physiol.224, 665 (1972).

    Google Scholar 

  80. Barker, L. A.,et al.: Biochem. J.130, 1063 (1972).

    Google Scholar 

  81. Chakrin, L. A.,et al.: J. Neurochem.19, 2727 (1972).

    Google Scholar 

  82. Winkler, H.,et al.: Naunyn-Schmiedeberg's Arch.273, 43 (1972).

    Google Scholar 

  83. Fillenz, M.: Phil. Trans. Roy. Soc.261, 319 (1971).

    Google Scholar 

  84. Rassin, D. K.: J. Neurochem.19, 139 (1972).

    Google Scholar 

  85. Fritsch, G.: Die elektrischen Fische, Zweite Abteilung: Die Torpedineen. Leipzig: von Weit 1890.

    Google Scholar 

  86. Grundfest, H.: Prog. Biophys. Mol. Biol.7, 1 (1957).

    Google Scholar 

  87. e.g. Bernstein, J., Tschermak, A.: Pflügers Arch. Ges. Physiol.112, 439 (1906).

    Google Scholar 

  88. Sheridan, M. N., Whittaker, V. P.: J. Physiol. Lond.175, 25P (1964).

    Google Scholar 

  89. Sheridan, M. N.et al.: Z. Zellforsch.74, 291 (1966).

    Google Scholar 

  90. Irsaël, M.,et al.: J. Neurochem.17, 1441 (1970).

    Google Scholar 

  91. Whittaker, V. P.,et al.: Biochem. J.128, 833 (1972).

    Google Scholar 

  92. Soifer, D., Whittaker, V. P.:ibid.128, 845 (1972).

    Google Scholar 

  93. Changeux, J.-P., in: Le système cholinergique en anesthésiologie et en réanimation (eds. G. G. Nahaset al.), p. 99. Paris: Arnette 1972.

    Google Scholar 

  94. [Anon.] Nature140, 323 (1972).

  95. Albe-Fessard, D.: Arch Scand. Physiol.4, 299 (1950).

    Google Scholar 

  96. Zimmermann, H., Whittaker, V. P.: J. Neurochem. (in press).

  97. Heuser, J., Miledi, R.: Proc. R. Soc., London B179, 247 (1971).

    Google Scholar 

  98. Korneliusson, H.: Z. Zellforsch.130, 28 (1972).

    Google Scholar 

  99. Whittaker, V. P.: Ann. N.Y. Acad. Sci.183, 21 (1971).

    Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry, University of Cambridge, England

    V. P. Whittaker

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Address from 30.6.73: Abteilung für Neurochemie, Max-Planck-Institut, für Biophysikalische Chemie, Göttingen-Nikolausberg, Germany.

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Whittaker, V.P. The biochemistry of synaptic transmission. Naturwissenschaften 60, 281–289 (1973). https://doi.org/10.1007/BF00624442

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