Zusammenfassung
Chlorpromazin (CPZ) bildet unter Aufnahme von Lichtquanten Radikale, die zu einer zunächst reversiblen, später stabilen Dimersierung führen. Im radikalen Zustand vermag sich CPZ mit biologischen Substraten zu koppeln. Die Bindung mit Proteinen bildet die Grundlage zur Photoallergie, diejenige mit RNS zur phototoxischen Wirkung und diejenige mit Melanoprotein zur CPZ-Pigmentierung.
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Jung, E.G. In vitro-Untersuchungen zur Chlorpromazine (CPZ)-Photoallergie. Arch. klin. exp. Derm. 237, 501–506 (1970). https://doi.org/10.1007/BF00641879
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DOI: https://doi.org/10.1007/BF00641879