Summary
Certain aspects of the pharmacodynamics of bacterial pyrogenic polysaccharides were studied in this work. It was established that there is an increase of the body temperature in animals, which lasts for 6–7 hours, following parenteral administration of this preparation in the dose from 1γ per kilogram and over. Preliminary administration of novocaine and anesthesia to these animals causes delay in the rise of body temperature and decreases the degree of its rise. The preparation has mild anti-inflammatory properties and its toxicity is low. It has no effect on respiration and blood pressure in the doses of 2–20 γ per kilogram of body weight. There is no disturbance of diuresis following administration of this preparation.
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Vasilyev, P.V., Saksonov, P.P. Pharmacology of pyrogenic bacterial polysaccharides. Bull Exp Biol Med 44, 1231–1234 (1957). https://doi.org/10.1007/BF00791112
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DOI: https://doi.org/10.1007/BF00791112