Skip to main content
Log in

Histamine receptors in primate gallbladder

  • Original Articles
  • Published:
Digestive Diseases and Sciences Aims and scope Submit manuscript

Abstract

The effect of intravenous histamine on intragallbaladder pressure (GBp) and subsequent modification of the histamine response by H1-and H2-antagonists was investigated in an awake baboon model. Responses to specific H1-and H2-agonists were also examined in order to further elucidate gallbladder histamine responses. Gallbladder volume (GBv) was arbitrarily set at 60–70% of observed resting GBv, and drugs were then infused intravenously with continuous monitoring of GBp. Histamine administration resulted in a logarithmic dose-response curve with a maximal increase in GBp equal to 31.7 mm Hg at a dose of 0.0625 mg of histamine. Infusion of the H1-antagonist diphenhydramine hydrochloride (Benadryl) resulted in a decreased GBp response to histamine when compared to preblocker response at all doses studied. On the other hand, histamine response following administration of the H2-antagonist metiamide was significantly greater than the preblocker histamine response. Infusion of the H1-agonist 2-pyridylethylamine resulted in a dose-dependent increase in GBp similar to the histamine curve, while infusion of the H2-agonist dimaprit resulted in consistent decreases in GBp. These results extend previous observations in subprimate preparations and demonstrate the presence of both stimulatory H1-receptors and inhibitory H2-receptors in anin situ primate model.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  1. Mack AJ, Todd JK: A study of human gallbladder musclein vitro. Gut 9:546–549, 1968

    Google Scholar 

  2. Wise WE, LaMorte WW, Gaca JM, Schoetz DJ, Birkett DH, Williams LF: Reciprocal H1- and H2-histamine receptors in guinea pig gallbladder. J Surg Res.

  3. Black JW, Duncan WAM: Defintion and antagonism of histamine H2-receptors. Nature 236:385–390, 1972

    Google Scholar 

  4. Waldman DB, Zfass AM, Maklouf GM: Stimulatory (H1-) and inhibitory (H2-) histamine receptors in gallbladder muscle. Gastroenterology 72:932–936, 1977

    Google Scholar 

  5. Impecciatore M: Occurrence of H1- and H2-histamine receptors in the guinea pig gallbladderin situ. Br J Pharmacol 64:219–222, 1978

    Google Scholar 

  6. Schoetz DJ, Birkett DH, Williams LF: Gallbladder motor function in the intact primate: Autonomic pharmacology. J Surg Res 24:513–519, 1978

    Google Scholar 

  7. Ravdin IS, Morrison JL: Gallbladder function. I. The contractile function of the gallbladder. Arch Surg 22:810–828, 1931

    Google Scholar 

  8. Gadacz TR: Effect of an H2-antagonist on gallbladder contraction. J Surg Res 25:334–341, 1978

    Google Scholar 

  9. LaMorte WW, Gaca JM, Wise WE, Birkett DH, Williams LF: Choledochal sphincter relaxation in response to histamine in the primate. J Surg Res 28:373–378, 1980

    Google Scholar 

  10. Tucker A, Weir EK, Reeves JT, Grover RF: Histamine H1-and H2-receptors in pulmonary and systemic vasculature of the dog. Am J Physiol 229:1008–1013, 1975

    Google Scholar 

  11. deCarle DJ, Brody MJ, Christensen J: Histamine receptors in esophageal smooth muscle of the opossum. Gastroenterology 70:1071–1075, 1976

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Supported by the National Institutes of Health grant AM15304-9

Rights and permissions

Reprints and permissions

About this article

Cite this article

Schoetz, D.J., Wise, W.E., La Morte, W.W. et al. Histamine receptors in primate gallbladder. Digest Dis Sci 28, 353–358 (1983). https://doi.org/10.1007/BF01324954

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01324954

Keywords