Abstract
Haematocrit (HCT) and viscosity of whole blood were measured in ten polycythaemic hyperviscous newborn infants both before and after dilutional partial exchange transfusion with 5% albumin. This was performed in order to evaluate the effect on the lowering of HCT and whole blood viscosity. Mean umbilical HCT values decreased from 68.7% before, to 54.4% post transfusion. This decrease in HCT and viscosity was highly significant (P<0.001). Safety and lack of complications make human albumin solution superior to human plasma for exchange transfusion in neonatal polycythaemia.
Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.Abbreviations
- HCT:
-
haematocrit
References
Black VD, Rumack CM, Lubchenco LD, Koops BL (1985) Gastrointestinal injury in polycythemic term infants. Pediatrics 76:225–231
Cuthbertson B, Rennie JG, Aw D, Reid KG (1987) Safety of albumin preparations manufactured from plasma not tested for HIV antibody. Lancet II:41
Ghosh S, Paton L (1985) Complications of therapeutic plasma exchange. Clin Lab Haematol 7:219–224
Linderkamp O, Versmold HT, Riegel KP, Betke K (1984) Contributions of red cells and plasma to blood viscosity in preterm and full term infants and adults. Pediatrics 74:45–51
Ring J, Messmer K (1977) Incidence and severity of anaphylactoid reactions to colloid volume substitutes. Lancet I:466–469
Shohat M, Merlob P, Reisner SH (1984) Neonatal polycythemia: I. Early diagnosis and incidence relating to time of sampling. Pediatrics 73:7–10
Shohat M, Reisner SH, Mimouni F, Merlob P (1984) Neonatal polycythemia: II. Definition related to time of sampling. Pediatrics 73:11–13
Wells JV, King MA (1980) Adverse reactions to human plasma protein. Anaesth Intensive Care 8:139–143
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Levy, I., Merlob, P., Ashkenazi, S. et al. Neonatal polycythaemia: Effect of partial dilutional exchange transfusion with human albumin on whole blood viscosity. Eur J Pediatr 149, 354–355 (1990). https://doi.org/10.1007/BF02171566
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02171566