Skip to main content
Springer Nature Link
Log in

The effects of DPPH on cochlear microcirculation

  • Published:
Current Medical Science Aims and scope Submit manuscript

Summary

To investigate the effects of the free radical, 1,2-Diphenyl-2-picylhydrazyl, on cochlear blood flow, 20 guinea pigs were divided into 3 groups at random, 6 for control group, 6 for 1 mmol/L group and 8 for 0.1 mmol/L group. 2 μl vehicle or drugs were dropped into round window membrane (RWM). Cochlear microcirculation was monitored by laser Doppler flowmeter (LDF), and mean arterial blood flow (MABP), which was transferred by pressure conductor sensor and preamplifier, was simultaneously recorded on the computer. Our results showed that MABP was stable throughout the experiment. Cochlear blood flow (CBF) increased by 10.32% (P <0.05) in 1 mmol/L group, and decreased by 4.89% in 0.1 mmol/L group (P<0.05). In control group cochlear microcirculation showed no significant changes. It is concluded that DPPH exerted effects on cochlear microcirculation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  1. Nuttall A L. Sound-induced cochlear ischemia/hypoxia as a mechanism of hearing loss. Noise Health, 1999, 2 (5):17

    PubMed  Google Scholar 

  2. Steven J K, Yukiyoshi H, Marcos G. Review of round window membrane permeability. Acta Otolaryngol (Stockh), 1988, S457: 43

    Google Scholar 

  3. Yamane H, Nakai Y, Takayama M,et al. Appearance of free radicals in the guinea pig inner ear after noise-induced acoustic trauma. Eur Arch Otorhinolaryngol, 1995, 252:504

    Article  CAS  PubMed  Google Scholar 

  4. Usami S, Hjelk O P, Ottersen O P, Differential cellular distribution of glutathione-an endogenous antioxidant-in the guinea pig inner ear. Brain Res, 1996, 743:337

    Article  CAS  PubMed  Google Scholar 

  5. Hjeller O P, Takumi Y, Makinae Ket al. In 28th Annual Meeting-Society for Neuroscience, Vol 24 Society for Neuroscience, Los Angeles, CA, 1998, pp. 903

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otolaryngology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan

    Kong Weijia & Chen Min

Authors
  1. Kong Weijia
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. Chen Min
    View author publications

    You can also search for this author inPubMed Google Scholar

Additional information

KONG Weijia male, born in 1955, Professor

This project was supported by grants of the Research Foundation for Outstanding Scientists (Serial No. 1995-144), the State Outstanding Young Scences Foundation (39925035) and Foundation for University Key Teachers by the Ministry of Education (2001).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Weijia, K., Min, C. The effects of DPPH on cochlear microcirculation. Current Medical Science 23, 198–200 (2003). https://doi.org/10.1007/BF02859957

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02859957

Key words