Skip to main content
Springer Nature Link
Log in

Metabolism of proteinoid microspheres

  • Conference paper
  • First Online:
Organic Geo- and Cosmochemistry

Part of the book series: Topics in Current Chemistry ((TOPCURRCHEM,volume 139))

  • 144 Accesses

Abstract

The literature of metabolism in proteinoids and proteinoid microspheres is reviewed and criticized from a biochemical and experimental point of view. Closely related literature is also reviewed in order to understand the function of proteinoids and proteinoid microspheres. Proteinoids or proteinoid microspheres have many activities. Esterolysis, decarboxylation, amination, deamination, and oxidoreduction are catabolic enzyme activities. The formation of ATP, peptides or oligonucleotides is synthetic enzyme activities. Additional activities are hormonal and inhibitory. Selective formation of peptides is an activity of nucleoproteinoid microspheres; these are a model for ribosomes. Mechanisms of peptide and oligonucleotide syntheses from amino acids and nucleotide triphosphate by proteinoid microspheres are tentatively proposed as an integrative consequence of reviewing the literature.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

7 References

  1. Fox, S. W., Harada, K.: J. Am. Chem. Soc. 82, 3745 (1960)

    Google Scholar 

  2. Fox, S. W., Dose, K.: Molecular Evolution and the Origin of Life, New York, Dekker 1977

    Google Scholar 

  3. Fox, S. W.: Naturwissenschaften 67, 378 (1980)

    Google Scholar 

  4. Nakashima, T., Jungck, J. R., Fox, S. W., Lederer, E., Das, B. C.: International Journal of Quantum Chemistry: Quantum Biology Symposium 4, 65 (1977)

    Google Scholar 

  5. Rohlfing, D. L., Fox, S. W.: Adv. Catalysis 20, 373 (1969)

    Google Scholar 

  6. Dose, K.: The evolution of individuality at the molecular and protocellular levels, in: Individuality and Determinism (ed.) Fox, S. W., p. 33, New York and London, Plenum Press 1984

    Google Scholar 

  7. Rohlfing, D. L., Fox, S. W.: Arch. Biochem. Biophys. 118, 122 (1967)

    Google Scholar 

  8. Rohlfing, D. L., Fox, S. W.: Arch. Biochem. Biophys. 118, 127 (1967)

    Google Scholar 

  9. Oshima, T.: Arch. Biochem. Biophys. 126, 478 (1968)

    Google Scholar 

  10. Tetas, M., Lowenstein, J. M.: Biochemistry 2, 350 (1963)

    Google Scholar 

  11. Fox, S. W., Wiggert, E., Joseph, D.: Simulated natural experiments in spontaneous organization of morphological units from proteinoid, in: The Origin of Prebiological Systems (ed.), Fox, S. W., p. 368, New York Academic Press 1965

    Google Scholar 

  12. Durant, D., Fox, S. W.: Federation Proc. 25, 342 (1966)

    Google Scholar 

  13. Fox, S. W., Adachi, T., Stillwell, W.: A quinone-assisted photoformation of energy-rich chemical bonds, in: Solar Energy: International Progress, Vol. 2 (ed.) Veziroglu, T. N., p. 1056, New York, Pergamon Press 1980

    Google Scholar 

  14. Fox, S. W., Adachi, T., Stillwell, W., Ishima, Y.: Photochemical synthesis of ATP: Protomembrans and protometabolism, in: Light Transducing Membranes: Structure, Function, Evolution (ed.) Deamer, D. W., p. 61, New York, Academic Press 1978

    Google Scholar 

  15. Krasnovsky, A. A.: Origins of Life 7, 133 (1976)

    Google Scholar 

  16. Penningroth, S. M., Olenhnik, K., Cheung, A.: J. Biol. Chem. 255, 9545 (1980)

    Google Scholar 

  17. Hammes, G. C.: Proc. Natl. Acad. Sci. 79, 6881 (1982)

    Google Scholar 

  18. Rohlfing, D. L.: Arch. Biochem. Biophys. 118, 468 (1967)

    Google Scholar 

  19. Rohlfing, D. L.: Science 169, 998 (1970)

    Google Scholar 

  20. Hardebeck, H. G., Krampitz, G., Wulf, L.: Arch. Biochem. Biophys. 123, 72 (1968)

    Google Scholar 

  21. Fox, S. W., Krampitz, G.: Nature 203, 1362 (1964)

    Google Scholar 

  22. Hardebeck, H. G., Haas, W.: Z. Naturforsch. 26b, 862 (1971)

    Google Scholar 

  23. Wood, A., Hardebech, H. G.: Light enhanced decarboxylations by Proteinoids, in: Molecular Evolution (eds.) Rohlfing, D. L., Oparin, A. I., p. 233, New York, Plenum Press 1972

    Google Scholar 

  24. Krampitz, G., Baars-Diehl, S., Haas, W., Nakashima, T.: Experientia 24, 140 (1968)

    Google Scholar 

  25. Krampitz, G., Haas, W., Baars-Diehl, S.: Naturwissenschaften 55, 345 (1968)

    Google Scholar 

  26. Dose, K., Zaki, L.: Z. Naturforsch. 26b, 144 (1971)

    Google Scholar 

  27. Nakashima, T., Fox, S. W.: J. Mol. Evol. 15, 161 (1980)

    Google Scholar 

  28. Nakashima, T., Fox, S. W.: BioSystems 14, 151 (1981)

    Google Scholar 

  29. Fox, S. W., Nakashima, T.: BioSystems 12, 155 (1980)

    Google Scholar 

  30. Lipmann, F.: Projecting backward from the present stage of evolution of biosynthesis, in: The Origins of Prebiological systems (ed.) Fox, S. W., p. 259, New York, Academic Press 1964

    Google Scholar 

  31. Lowenstein, J. M.: Biochim. Biophys. Acta 28, 206 (1958)

    Google Scholar 

  32. Ryan, J. W. and Fox, S. W.: BioSystems 5, 115 (1973)

    Google Scholar 

  33. Lowenstein, J. M., Schatz, M. N.: J. Biol. Chem. 236, 305 (1961)

    Google Scholar 

  34. Lohrmann, R., Orgel, L. E.: Nature 244, 418 (1973)

    Google Scholar 

  35. Sawai, H., Lohrmann, R., Orgel, L. E.: J. Mol. Evol. 6, 165 (1975)

    Google Scholar 

  36. Weber, A. L., Caroon, J. W., Warden, J. T., Lemmon, R. M., Calvin, M.: BioSystems 8, 277 (1977)

    Google Scholar 

  37. Lohrmann, R., Ranganathan, R., Sawai, H., Orgel, L. E.: J. Mol. Evol. 5, 57 (1975)

    Google Scholar 

  38. Berg, P.: J. Biol. Chem. 233, 608 (1958)

    Google Scholar 

  39. Paecht-Horowitz, M., Katchalsky, A.: Biochim. Biophys. Acta 140, 14 (1967)

    Google Scholar 

  40. Paecht-Horowitz, M., Katchalsky, A.: Biochim. Biophys. Acta 140, 24 (1967)

    Google Scholar 

  41. Ishigami, M., Tonotsuka-Ohta, N., Nagano, K., Kinjo, M.: Origin of Life 10, 293 (1980)

    Google Scholar 

  42. Lacey, J. C., White, W. E.: Biochem. Biophys. Res. Comm. 47, 565 (1972)

    Google Scholar 

  43. Weber, A. L., Lacey, J. C.: Biochim. Biophys. Acta 349, 226 (1974)

    Google Scholar 

  44. Honda, Y., Yamanashi, H., Imahori, K., Yuasa, S.: Affinity of adenylate derivatives for thermal Polyamino acids, in: Origin of Life; Proceedings of the Second ISSOL Meeting, the Fifth ICOL Meeting (ed.) Noda, H., p. 315, Japan, Bus. Cent. Acad. Soc. Japan 1978

    Google Scholar 

  45. Harris, R. J., Pestka, S.: Peptide bond formation, in: Molecular Mechanisms of Protein Biosynthesis (eds.) Weissbach, H., Pestka, S., p. 413, New York, Academic Press 1977

    Google Scholar 

  46. Krayevsky, A. A., Kukhanova, M. K.: The peptidyltransferase center of ribosomes, in: Progress in Nucleic Acid Research and Molecular Biology, Vol. 23, p. 1, New York, Academic Press 1979

    Google Scholar 

  47. Jungck, J. R., Fox, S. W.: Naturwissenschaften 60, 425 (1973)

    Google Scholar 

  48. Liebl, V., Novák, V., Bejšovcová, L., Masinovskij, Z., Oparin, A. I.: Polymerization of radioactive adenosine diphosphate by polynucleotide-phosphorylase or by proteinoids in microsystems, in: Origin of Life; Proceedings of the Second ISSOL Meeting, the Fifth ICOL Meeting (ed.) Noda, H., p. 363, Japan, Bus. Cent. Acad. Soc. Japan 1978

    Google Scholar 

  49. Lohrmann, R., Orgel, L. E.: J. Mol. Evol. 7, 253 (1976)

    Google Scholar 

  50. Sawai, H.: J. Am. Chem. Soc. 98, 7037 (1976)

    Google Scholar 

  51. Sleeper, H. L., Lohrmann, R., Orgel, L. E.: J. Mol. Evol. 13, 203 (1979)

    Google Scholar 

  52. Fakhrai, H., van Roode, J. H. G., Orgel, L. E.: J. Mol. Evol. 17, 295 (1981)

    Google Scholar 

  53. Fox, S. W.: A model for protocellular coordination of nucleic acid and protein syntheses, in: Science and Scientists (eds.) Kageyama, M., Nakamure, K., Oshima, T., Uchida, T., p. 39, Tokyo, Japan Scientific Societiers Press 1981

    Google Scholar 

  54. Waehneldt, T. V., Fox, S. W.: Biochim. Biophys. Acta 160, 239 (1968)

    Google Scholar 

  55. Miquel, J., Brooke, S., Fox, S. W.: Currents in Modern Biology 3, 299 (1971)

    Google Scholar 

  56. Lacey, J. C., Yuki, A., Fox, S. W.: BioSystems 11, 1 (1979)

    Google Scholar 

  57. Yuki, A., Fox, S. W.: Biochem. Biophys. Res. Comm. 36, 657 (1969)

    Google Scholar 

  58. Lacey, J. C., Stephens, D. P., Fox, S. W.: BioSystems 11, 9 (1979)

    Google Scholar 

  59. Nakashima, T., Fox, S. W.: Proc. Nat. Acad. Sci. USA 69, 106 (1972)

    Google Scholar 

  60. Nakashima, T., Fox, S. W.: Model Ribosomes, in: From Gene to Protein: Translation into Biotechnology, The Fourteenth Miami Winter Symposium (eds.) Ahmad, F., Schultz, E. E., Whelan, W. J.: p. 81, University of Miami, School of Medicine 1982

    Google Scholar 

  61. Nakashima, T.: Protoribosomes, in Molecular Evolution and Protobiology (eds.) Matsuno, K., Dose, K., Harada, K., Rohlfing, D. L.: p. 215, New York and London, Plenum Press 1984

    Google Scholar 

  62. Fox, S. W., Nakashima, T.: Biochim. Biophys. Acta 140, 155 (1967)

    Google Scholar 

  63. Fox, S. W., Waehneldt, T. V.: Biochim. Biophys. Acta. 160, 246 (1968)

    Google Scholar 

  64. Kurland, C. G.: Aspects of ribosome structure and function, in: Molecular Mechanisms of Protein Biosynthesis (eds.) Weissbach, H., Pestka, S., p. 81, New York, Academic Press 1977

    Google Scholar 

  65. Fox, S. W., Wang, C. T.: Science 160, 547 (1968)

    Google Scholar 

  66. Fox, S. W., Syren, R. M., Windsor, C. R.: Thermal copoly(amino acids) as inhibitors of glyoxalase I, in Submolecular Biology and Cancer (ed.) Wostenholme, G., p. 175, London, Ciba Foundation 1979

    Google Scholar 

  67. Syren, R. M., Windsor, C. R., Fox, S. W.: International Journal of Quantum Chemistry: Quantum Biology Symposium 6, 283 (1979)

    Google Scholar 

  68. Haas, W., Hardebeck, H. G.: Naturwissenschaften 56, 220 (1969)

    Google Scholar 

  69. Krampitz, G., Fox, S. W.: Proc. Nat. Acad. Soc. USA 62, 399 (1969)

    Google Scholar 

  70. Nakashima, T., Fox, S. W.: in preparation

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute for Molecular and Cellular Evolution University of Miami, Coral Gables, Florida, USA

    Tadayoshi Nakashima

Authors
  1. Tadayoshi Nakashima
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer-Verlag

About this paper

Cite this paper

Nakashima, T. (1987). Metabolism of proteinoid microspheres. In: Organic Geo- and Cosmochemistry. Topics in Current Chemistry, vol 139. Springer, Berlin, Heidelberg. https://doi.org/10.1007/BFb0018078

Download citation

  • DOI: https://doi.org/10.1007/BFb0018078

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-17010-5

  • Online ISBN: 978-3-540-47197-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics