Skip to main content

Advertisement

Springer Nature Link
Log in

Ultrasensitive voltammetric detection of an antimalarial drug (amodiaquine) at a disposable and low cost electrode

  • Original Paper
  • Published:
Monatshefte für Chemie - Chemical Monthly Aims and scope Submit manuscript

Abstract

In this study, an ultrasensitive electrochemical determination of an antimalarial drug, amodiaquine (ADQ), was described at a cheap and disposable pencil graphite electrode (PGE) which offers a renewable sensing surface for each measurement. The electrochemical behavior of ADQ was investigated on various carboneous electrodes. Cyclic voltammograms showed that ADQ gives reversible peaks at all electrodes. However, the highest currents for oxidation of ADQ and reduction of the oxidized form of ADQ (ADQ(Ox)) among the carboneous electrodes were obtained in the case of using PGE and these redox couple become more reversible and sharper at PGE than the other electrodes. DP voltammograms also showed that the oxidation peak current of ADQ at PGE is about five times higher than at other electrodes. All these results indicate that bare PGE without any modification exhibits an excellent electrocatalytic activity towards oxidation of ADQ. DP voltammetric studies show a wide linear dynamic range from 1.0 to 200 nM with a detection limit and sensitivity of 0.30 nM and 50 µA µM−1, respectively. The recovery of ADQ spiked into some different samples was studied. Obtained recovery values (99.2–102.0%) confirmed that non-modified PGE can be used for the ultrasensitive and accurate electrochemical quantification of ADQ in different samples.

Graphic abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

  1. Rathod GN, Lokhande VM (2014) World J Pharm Res 3:1739

    CAS  Google Scholar 

  2. Malongo TK, Blankert B, Kambu O, Amighi K, Nsangu J, Kauffmann JM (2006) J Pharm Biomed Anal 41:70

    CAS  PubMed  Google Scholar 

  3. Samari F, Shamsipur M, Hemmateenejad B, Khayamian T, Gharaghani S (2012) Eur J Med Chem 54:255

    CAS  PubMed  Google Scholar 

  4. Ansari MT, Ansari TM, Raza A, Ashraf M, Yar M (2008) Chem Anal (Warsaw) 53:305

    CAS  Google Scholar 

  5. Durrani N, Leslie T, Rahim S, Graham K, Ahmad F, Rowland M (2005) Trop Med Int Health 10:521

    CAS  PubMed  Google Scholar 

  6. Mount DL, Patchen LC, Nguyen-Dinh P, Barber AM, Schwartz IK, Churchill FC (1986) J Chromatogr B Biomed Sci Appl 383:375

    CAS  Google Scholar 

  7. Sanghi SK, Verma A, Verma KK (1990) Analyst 115:333

    PubMed  Google Scholar 

  8. Ibrahim FA, Belal F, El-Brashy A (1989) Microchem J 39:65

    CAS  Google Scholar 

  9. Amin AS, Issa YM (2003) J Pharm Biomed Anal 31:785

    CAS  PubMed  Google Scholar 

  10. Mufusama JP, Hoellein L, Feineis D, Holzgrabe U, Bringmann G (2018) Electrophoresis 39:2530

    CAS  PubMed  Google Scholar 

  11. Valente CO, Garcia CAB, Alves JPH, Zanoni MVB, Stradiotto NR, Arguelho MLPM (2012) ECS Trans 43:297

    CAS  Google Scholar 

  12. Chiwunze TE, Palakollu VN, Gilla AAS, Kayamba F, Thapliyal NB, Karpoormath R (2019) Mater Sci Eng C 97:285

    CAS  Google Scholar 

  13. Thirumalraj B, Rajkumar C, Chen SM, Dhenadhayalan N, Lin KC (2017) ChemElectroChem 4:2842

    CAS  Google Scholar 

  14. Karakaya S (2019) Monatsh Chem 150:1911

    CAS  Google Scholar 

  15. Karakaya S, Dilgin DG (2019) Monatsh Chem 150:1003

    CAS  Google Scholar 

  16. Sakthinathan S, Tamizhdurai P, Ramesh A, Chiu TW, Mangesh VL, Veerarajan S, Shanthi K (2020) Micropor Mesopor Mater 292:109770

    CAS  Google Scholar 

  17. Suna G, Wang S, Jianfeng Z, Jianbin P, Tong Y, Qinghua M, Zhai H (2020) Microchem J 152:104438

    Google Scholar 

  18. Dang W, Sun Y, Jiao H, Xu L, Lin M (2020) J Electroanal Chem 856:113592

    CAS  Google Scholar 

  19. Vinoth S, Ramaraj R, Pandikumar A (2020) Mater Chem Phys 245:122743

    CAS  Google Scholar 

  20. Xue Z, Jia L, Zhu RR, Du L, Zhao QH (2020) J Electroanal Chem 858:113783

    CAS  Google Scholar 

  21. Cong C, Biana K, Zhang X, Luo L, Li L, He H, Li C, Zhao Q, Wang S, Hao Z, He Y, Gao D (2020) Talanta 208:120286

    CAS  PubMed  Google Scholar 

  22. Sharma S, Jain R, Raja AN (2020) J Electrochem Soc 167:037501

    Google Scholar 

  23. Masawat P, Liawruangrath S, Vaneesorn Y, Liawruangrath B (2002) Talanta 58:1221

    CAS  PubMed  Google Scholar 

  24. Akanda MR, Sohail M, Aziz MA, Kawde AN (2016) Electroanalysis 28:408

    CAS  Google Scholar 

  25. Wang J, Kawde AN, Sahlin E (2000) Analyst 125:5

    CAS  PubMed  Google Scholar 

  26. David IG, Popa DE, Buleandra M (2017) J Anal Methods Chem 2017:1905968

    PubMed  PubMed Central  Google Scholar 

  27. Kawde AN, Baig N, Sajid M (2016) RSC Adv 6:91325

    CAS  Google Scholar 

  28. Baysal G, Uzun D, Hasdemir E (2020) J Electroanal Chem 860:113893

    CAS  Google Scholar 

  29. Moradi S, Azizi-Lalabadi M, Bagheri V, Sadeghi E (2020) Sens BioSensing Res 28:100321

    Google Scholar 

  30. Ayaz S, Karakaya S, Emir G, Dilgin DG, Dilgin Y (2020) Microchem J 154:104586

    CAS  Google Scholar 

  31. Oghli AH, Soleymanpour A (2020) Mater Sci Eng C 108:110407

    CAS  Google Scholar 

  32. Emir G, Dilgin Y, Apak R (2020) ChemElectroChem 7:649

    CAS  Google Scholar 

  33. da Fonseca AR, Franco DL, Cordeiro MT, de Oliveira Júnior EM, Dutra RAF, Sotomayo MDPT (2019) Sens Actuator B Chem 296:126681

    Google Scholar 

  34. Prasad BB, Singh K (2017) Sens Actuator B Chem 244:167

    CAS  Google Scholar 

  35. Sağlam Ö, Dilgin DG, Ertek B, Dilgin Y (2016) Mater Sci Eng C 60:156

    Google Scholar 

  36. Dilgin DG, Karakaya S (2016) Mater Sci Eng C 63:570

    CAS  Google Scholar 

  37. Vu DL, Ertek B, Dilgin Y, Červenka L (2015) Czech J Food Sci 33:72

    CAS  Google Scholar 

  38. Dede E, Sağlam Ö, Dilgin Y (2014) Electrochim Acta 127:20

    CAS  Google Scholar 

  39. Purushothama HT, Arthoba Nayaka Y, Vinay MM, Manjunatha P, Yathisha RO, Basavarajappa KV (2018) J Sci Adv Mater Devices 3:161

    Google Scholar 

  40. Yardim Y, Senturk Z (2013) Talanta 112:11

    CAS  PubMed  Google Scholar 

  41. Levent A, Yardim Y, Senturk Z (2009) Electrochim Acta 55:190

    CAS  Google Scholar 

  42. Aydın İ, Pelit L, Ertaş FN (2018) Anal Lett 51:209

    Google Scholar 

  43. Kariuki JK (2012) J Electrochem Soc 159:H747

    CAS  Google Scholar 

  44. Shiu K-K, Shi K (1998) Electroanalysis 10:959

    CAS  Google Scholar 

  45. Özcan HM, Sezgintürk MK (2015) Biotechnol Prog 31:815

    PubMed  Google Scholar 

  46. Sousa MC, Buchana JW (2000) Comput Graph Forum 19:27

    Google Scholar 

Download references

Acknowledgements

This work was supported by The Scientific Research Coordination Unit of Çanakkale Onsekiz Mart University, Project number: FBA-2019-3046.

Author information

Authors and Affiliations

  1. Department of Chemistry, Faculty of Science and Arts, Çanakkale Onsekiz Mart University, 17100, Çanakkale, Turkey

    Serkan Karakaya, Burcu Kartal & Yusuf Dilgin

Authors
  1. Serkan Karakaya
    View author publications

    Search author on:PubMed Google Scholar

  2. Burcu Kartal
    View author publications

    Search author on:PubMed Google Scholar

  3. Yusuf Dilgin
    View author publications

    Search author on:PubMed Google Scholar

Corresponding author

Correspondence to Serkan Karakaya.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary file1 (DOCX 206 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Karakaya, S., Kartal, B. & Dilgin, Y. Ultrasensitive voltammetric detection of an antimalarial drug (amodiaquine) at a disposable and low cost electrode. Monatsh Chem 151, 1019–1026 (2020). https://doi.org/10.1007/s00706-020-02637-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00706-020-02637-y

Keywords

Profiles

  1. Serkan Karakaya View author profile