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Apoptose: Prinzipien der Apoptosesignaltransduktion

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Literatur

  1. Kerr JFR et al. (1972) Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 26: 239–257

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Strasser A et al. (2000) Apoptosis signaling. Annu Rev Biochem. 69: 217–245

    Article  CAS  PubMed  Google Scholar 

  3. Savill J, Fadok V (2000) Corpse clearance defines the meaning of cell death. Nature 407: 784–788

    Article  CAS  PubMed  Google Scholar 

  4. Salvesen GS, Dixit VM (1999) Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A 96: 10964–10967

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Slee EA et al. (1999) Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ 6: 1067–1074

    Article  CAS  PubMed  Google Scholar 

  6. Fischer U et al. (2003) Many cuts to ruin: a comprehensive update of caspase substrates. Cell Death Differ 10: 76–100

    Article  CAS  PubMed  Google Scholar 

  7. Schulze-Osthoff K et al. (1998) Apoptosis signaling by death receptor. Eur J Biochem 254: 439–459

    Article  CAS  PubMed  Google Scholar 

  8. Medema JP et al. (1997) FLICE is activated by association with the CD95 death-inducing signaling complex (DISC). EMBO J 16: 2794–2804

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Zhou P et al. (1999) Solution structure of Apaf-1 CARD and its interaction with caspase-9 CARD: a structural basis for specific adaptor/caspase interaction. Proc Natl Acad Sci U S A 96: 11265–11270

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Cain K et al. (2002) The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie 84: 203–214

    Article  CAS  PubMed  Google Scholar 

  11. Rao RV et al. (2002) Coupling endoplasmic reticulum stress to the cell death program. An Apaf-1-independent intrinsic pathway. J Biol Chem 277: 21836–21842

    Article  CAS  PubMed  Google Scholar 

  12. Leist M, Jaattela M (2001) Triggering of apoptosis by cathepsins. Cell Death Differ 8: 324–326

    Article  CAS  PubMed  Google Scholar 

  13. Adams JM, Cory S (2001) Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci 26: 61–66

    Article  CAS  PubMed  Google Scholar 

  14. Bouillet P, Strasser A (2002) BH3-only proteins—evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death. J Cell Sci 115: 1567–1574

    CAS  PubMed  Google Scholar 

  15. Deveraux QL, Reed JC (1999) IAP family proteins—suppressors of apoptosis. Genes Dev 13: 239–252

    Article  CAS  PubMed  Google Scholar 

  16. Hetts SW (1998) To die or not to die: an overview of apoptosis and its role in disease. Jama 279: 300–307

    Article  CAS  PubMed  Google Scholar 

  17. Rosen A, Casciola-Rosen L (1999) Autoantigens as substrates for apoptotic proteases: implications for the pathogenesis of systemic autoimmune disease. Cell Death Differ 6: 6–12

    Article  CAS  PubMed  Google Scholar 

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Lauber, K., Engels, I.H. & Wesselborg, S. Apoptose: Prinzipien der Apoptosesignaltransduktion. Onkologe 10 (Suppl 1), S58–S61 (2004). https://doi.org/10.1007/s00761-003-0645-4

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