Abstract
Primary hypertrophic osteoarthropathy (PHO) is a rare systemic disorder characterized. by periosteal new bone formation, clubbing of fingers and toes, and thickening of the. skin, particularly on the forehead and face. This case study presents a 24-year-old. male patient with a decade-long history of prominent skin folds on the forehead and. face, joint swelling in hands and feet, and calf pain. Clinical manifestations included. progressive facial wrinkling, thickening of distal joints, and cortical thickening observed. on X-rays. Serum levels of insulin-like growth factor (IGF-1), thyroid function, rheumatoid factor, and anti-cyclic citrullinated peptide were within normal ranges. The diagnosis was confirmed through a comprehensive evaluation of clinical, radiological, and laboratory findings. This report underscores the importance of recognizing the. distinct features of PHO for accurate diagnosis and timely management.
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The datasets analyzed for this study are available from the corresponding author Dr. Chen Li (casio1981@163.com) upon reasonable request.
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Funding
This work was supported by grants from the National Natural Science Foundation of China (82074246, 82374272).
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HRY: conceptualization, methodology, software, investigation, writing—review and editing. YXB: conceptualization, methodology, software, investigation, writing—review and editing. LZM: conceptualization, methodology, software, investigation, writing—review and editing. WSF: visualization, investigation. CNG: visualization, investigation. GYW: software, validation. LC: conceptualization, funding acquisition, resources, supervision. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
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Hu, R., Yu, X., Lin, Z. et al. History of primary hypertrophic osteoarthropathy. Clin Rheumatol 44, 2067–2069 (2025). https://doi.org/10.1007/s10067-025-07405-z
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DOI: https://doi.org/10.1007/s10067-025-07405-z