Skip to main content

Advertisement

Log in

Recurrent Urinary Tract Infections and Asymptomatic Bacteriuria in Adults

  • Inflammatory/Infectious Bladder Disorders (MS Mourad, Section Editor)
  • Published:
Current Bladder Dysfunction Reports Aims and scope Submit manuscript

Abstract

Purpose of review

Our goal was to summarize recent evidence regarding recurrent urinary tract infections and asymptomatic bacteriuria in different adult populations.

Recent findings

Several research groups are focused on the description of resident bacterial flora in the bladder and urinary dysbiosis in the microbiome era. Even the definitions might change in light of these discoveries. However, the role of urinary microbiome and bacterial interference has still to be determined.

Summary

Systematic treatment of asymptomatic bacteriuria is not recommended and even classic indications such as asymptomatic bacteriuria in pregnant women are controversial. In fact, its treatment is associated with a higher probability of symptomatic UTI and a higher prevalence of antibiotic-resistant bacteria. Improving the diagnosis of asymptomatic bacteriuria and optimizing the management of recurrent urinary tract infections, especially through non-antibiotics measures, are needed in order to minimise antimicrobial resistance.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Explore related subjects

Discover the latest articles and news from researchers in related subjects, suggested using machine learning.

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Bonkat (Chair) G, Bartoletti R, Bruyère F, Cai T, Geerlings SE, Köves B, et al. European Association of Urology (EAU) Guidelines on Urological Infections. presented at the EAU Annual Congress Milan Italy 2021 ed. Arnhem, the Netherlands: EAU Guidelines Office; 2021.

  2. Dason S, Dason JT, Kapoor A. Guidelines for the diagnosis and management of recurrent urinary tract infection in women. Can Urol Assoc J. 2011;5(5):316–22. https://doi.org/10.5489/cuaj.11214.

    Article  PubMed  PubMed Central  Google Scholar 

  3. • Groah SL, Pérez-Losada M, Caldovic L, Ljungberg IH, Sprague BM, Castro-Nallar E, et al. Redefining Healthy Urine: A Cross-Sectional Exploratory Metagenomic Study of People With and Without Bladder Dysfunction. J Urol. 2016;196(2):579–87. https://doi.org/10.1016/j.juro.2016.01.088. Thereareimportantdifferencesintheurinemicrobiomeofhealthyindividualswithrespecttootherswithneurogenicbladder.

    Article  PubMed  Google Scholar 

  4. Brubaker L, Nager CW, Richter HE, Visco A, Nygaard I, Barber MD, et al. Urinary bacteria in adult women with urgency urinary incontinence. Int Urogynecol J. 2014;25(9):1179–84. https://doi.org/10.1007/s00192-013-2325-2.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Pearce MM, Zilliox MJ, Rosenfeld AB, Thomas-White KJ, Richter HE, Nager CW, et al. The female urinary microbiome in urgency urinary incontinence. Am J Obstet Gynecol. 2015;213(3):347.e1-11. https://doi.org/10.1016/j.ajog.2015.07.009.

    Article  Google Scholar 

  6. Neugent ML, Hulyalkar NV, Nguyen VH, Zimmern PE, De Nisco NJ. Advances in Understanding the Human Urinary Microbiome and Its Potential Role in Urinary Tract Infection. mBio. 2020;11(2). https://doi.org/10.1128/mBio.00218-20.

  7. •• Finucane TE. “Urinary Tract Infection”-Requiem for a Heavyweight. J Am Geriatrics Soc. 2017;65(8):1650–5. https://doi.org/10.1111/jgs.14907. Significant bacteriuria and urinary symptoms often occur simultaneously, and that should not trigger antibiotic treatment . The term UTI maybe shoul be revised.

    Article  Google Scholar 

  8. Morand A, Cornu F, Dufour JC, Tsimaratos M, Lagier JC, Raoult D. Human Bacterial Repertoire of the Urinary Tract: a Potential Paradigm Shift. J Clin Microbiol. 2019;57(3). https://doi.org/10.1128/jcm.00675-18.

  9. Bossa L, Kline K, McDougald D, Lee BB, Rice SA. Urinary catheter-associated microbiota change in accordance with treatment and infection status. PLoS One. 2017;12(6): e0177633. https://doi.org/10.1371/journal.pone.0177633.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Cai T, Koves B, Johansen TE. Asymptomatic bacteriuria, to screen or not to screen - and when to treat? Curr Opin Urol. 2017;27(2):107–11. https://doi.org/10.1097/mou.0000000000000368.

    Article  PubMed  Google Scholar 

  11. Cai T, Bartoletti R. Asymptomatic bacteriuria in recurrent UTI - to treat or not to treat. GMS Infect Dis. 2017;5:Doc09. https://doi.org/10.3205/id000035.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Lee MJ, Kim M, Kim NH, Kim CJ, Song KH, Choe PG, et al. Why is asymptomatic bacteriuria overtreated?: A tertiary care institutional survey of resident physicians. BMC Infect Dis. 2015;15:289. https://doi.org/10.1186/s12879-015-1044-3.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Cai T, Mazzoli S, Lanzafame P, Caciagli P, Malossini G, Nesi G, et al. Asymptomatic Bacteriuria in Clinical Urological Practice: Preoperative Control of Bacteriuria and Management of Recurrent UTI. Pathogens (Basel, Switzerland). 2016;5(1). https://doi.org/10.3390/pathogens5010004.

  14. Medina M, Castillo-Pino E. An introduction to the epidemiology and burden of urinary tract infections. Ther Adv Urol. 2019;11:1756287219832172. https://doi.org/10.1177/1756287219832172.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Schappert SM, Rechtsteiner EA. Ambulatory medical care utilization estimates for 2007. Vital and health statistics Series 13, Data from the National Health Survey. 2011(169):1-38.

  16. MacVane SH, Tuttle LO, Nicolau DP. Demography and burden of care associated with patients readmitted for urinary tract infection. J Microbiol Immunol Infect. 2015;48(5):517–24. https://doi.org/10.1016/j.jmii.2014.04.002.

    Article  PubMed  Google Scholar 

  17. Tandogdu Z, Cek M, Wagenlehner F, Naber K, Tenke P, van Ostrum E, et al. Resistance patterns of nosocomial urinary tract infections in urology departments: 8-year results of the global prevalence of infections in urology study. World J Urol. 2014;32(3):791–801. https://doi.org/10.1007/s00345-013-1154-8.

    Article  CAS  PubMed  Google Scholar 

  18. Allegranzi B, Bagheri Nejad S, Combescure C, Graafmans W, Attar H, Donaldson L, et al. Burden of endemic health-care-associated infection in developing countries: systematic review and meta-analysis. Lancet (London, England). 2011;377(9761):228–41. https://doi.org/10.1016/s0140-6736(10)61458-4.

    Article  Google Scholar 

  19. Tandogdu Z, Wagenlehner FM. Global epidemiology of urinary tract infections. Curr Opin Infect Dis. 2016;29(1):73–9. https://doi.org/10.1097/qco.0000000000000228.

    Article  PubMed  Google Scholar 

  20. Colgan R, Nicolle LE, McGlone A, Hooton TM. Asymptomatic bacteriuria in adults. Am Fam Physician. 2006;74(6):985–90.

    PubMed  Google Scholar 

  21. •• Nicolle LE, Gupta K, Bradley SF, Colgan R, DeMuri GP, Drekonja D, et al. Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2019;68(10):1611–5. https://doi.org/10.1093/cid/ciz021. ClinicalpracticeguidelineoftheInfectiousDiseasesSocietyofAmericasummarisingtheevidence-basedrecommendationsregardingthemanagementofasymptomaticbacteriuria.

    Article  PubMed  Google Scholar 

  22. Glaser AP, Schaeffer AJ. Urinary Tract Infection and Bacteriuria in Pregnancy. Urol Clinics N Am. 2015;42(4):547–60. https://doi.org/10.1016/j.ucl.2015.05.004.

    Article  Google Scholar 

  23. Laway BA, Nabi T, Bhat MH, Fomda BA. Prevalence, clinical profile and follow up of asymptomatic bacteriuria in patients with type 2 diabetes-prospective case control study in Srinagar, India. Diabetes Metab Syndrome. 2021;15(1):455–9. https://doi.org/10.1016/j.dsx.2020.12.043.

    Article  Google Scholar 

  24. Czajkowski K, Broś-Konopielko M, Teliga-Czajkowska J. Urinary tract infection in women. Przeglad Menopauzalny Menopause Rev. 2021;20(1):40–7. https://doi.org/10.5114/pm.2021.105382.

    Article  CAS  Google Scholar 

  25. Mitchell BG, Prael G, Curryer C, Russo PL, Fasugba O, Lowthian J, et al. The frequency of urinary tract infections and the value of antiseptics in community-dwelling people who undertake intermittent urinary catheterization: A systematic review. Am J Infect Control. 2021. https://doi.org/10.1016/j.ajic.2021.01.009.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Tornic J, Wöllner J, Leitner L, Mehnert U, Bachmann LM, Kessler TM. The Challenge of Asymptomatic Bacteriuria and Symptomatic Urinary Tract Infections in Patients with Neurogenic Lower Urinary Tract Dysfunction. J Urol. 2020;203(3):579–84. https://doi.org/10.1097/ju.0000000000000555.

    Article  PubMed  Google Scholar 

  27. Kim BR, Lim JH, Lee SA, Kim JH, Koh SE, Lee IS, et al. The Relation between Postvoid Residual and Occurrence of Urinary Tract Infection after Stroke in Rehabilitation Unit. Ann Rehabil Med. 2012;36(2):248–53. https://doi.org/10.5535/arm.2012.36.2.248.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Castle AC, Park A, Mitchell AJ, Bliss DZ, Gelfand JA, De EJB. Neurogenic Bladder: Recurrent Urinary Tract Infections—Beyond Antibiotics. Curr Bladder Dysfunct Rep. 2018;13(4):191–200. https://doi.org/10.1007/s11884-018-0481-4.

    Article  Google Scholar 

  29. Hilt EE, McKinley K, Pearce MM, Rosenfeld AB, Zilliox MJ, Mueller ER, et al. Urine is not sterile: Use of enhanced urine culture techniques to detect resident bacterial flora in the adult female bladder. J Clin Microbiol. 2014;52(3):871–6. https://doi.org/10.1128/JCM.02876-13.

    Article  PubMed  PubMed Central  Google Scholar 

  30. • Milestones in human microbiota research. Nature portfolio. 2019. https://www.nature.com/collections/microbiota-milestone. Review of the most important milestones in the discovery and research in human microbiota.

  31. Ackerman AL, Chai TC. The Bladder is Not Sterile: an Update on the Urinary Microbiome. Curr Bladder Dysfunct Rep. 2019;14(4):331–41. https://doi.org/10.1007/s11884-019-00543-6.

    Article  PubMed  PubMed Central  Google Scholar 

  32. Yoo JJ, Shin HB, Song JS, Kim M, Yun J, Kim Z, et al. Urinary Microbiome Characteristics in Female Patients with Acute Uncomplicated Cystitis and Recurrent Cystitis. J Clin Med. 2021;10(5). https://doi.org/10.3390/jcm10051097.

  33. Meštrović T, Matijašić M, Perić M, Čipčić Paljetak H, Barešić A, Verbanac D. The Role of Gut, Vaginal, and Urinary Microbiome in Urinary Tract Infections: From Bench to Bedside. Diagnostics (Basel, Switzerland). 2020;11(1). https://doi.org/10.3390/diagnostics11010007.

  34. Brubaker L, Wolfe AJ. The female urinary microbiota, urinary health and common urinary disorders. Ann Transl Med. 2017;5(2):34. https://doi.org/10.21037/atm.2016.11.62.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Price TK, Dune T, Hilt EE, Thomas-White KJ, Kliethermes S, Brincat C, et al. The Clinical Urine Culture: Enhanced Techniques Improve Detection of Clinically Relevant Microorganisms. J Clin Microbiol. 2016;54(5):1216–22. https://doi.org/10.1128/jcm.00044-16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012;13(4):260–70. https://doi.org/10.1038/nrg3182.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Schreiber HLt, Conover MS, Chou WC, Hibbing ME, Manson AL, Dodson KW, et al. Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections. Sci Transl Med. 2017;9(382). https://doi.org/10.1126/scitranslmed.aaf1283.

  38. Justice SS, Hung C, Theriot JA, Fletcher DA, Anderson GG, Footer MJ, et al. Differentiation and developmental pathways of uropathogenic Escherichia coli in urinary tract pathogenesis. Proc Natl Acad Sci USA. 2004;101(5):1333–8. https://doi.org/10.1073/pnas.0308125100.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Schwartz DJ, Kalas V, Pinkner JS, Chen SL, Spaulding CN, Dodson KW, et al. Positively selected FimH residues enhance virulence during urinary tract infection by altering FimH conformation. Proc Natl Acad Sci USA. 2013;110(39):15530–7. https://doi.org/10.1073/pnas.1315203110.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Robino L, Scavone P, Araujo L, Algorta G, Zunino P, Vignoli R. Detection of intracellular bacterial communities in a child with Escherichia coli recurrent urinary tract infections. Pathogens Dis. 2013;68(3):78–81. https://doi.org/10.1111/2049-632x.12047.

    Article  CAS  Google Scholar 

  41. de Cueto M, Aliaga L, Alós JI, Canut A, Los-Arcos I, Martínez JA, et al. Executive summary of the diagnosis and treatment of urinary tract infection: Guidelines of the Spanish Society of Clinical Microbiology and Infectious Diseases (SEIMC). Enferm Infecc Microbiol Clin. 2017;35(5):314–20. https://doi.org/10.1016/j.eimc.2016.11.005.

    Article  PubMed  Google Scholar 

  42. Management of suspected bacterial urinary tract infection in adults. A national clinical guideline (SIGN publication no. 88). Edinburgh: Scottish Intercollegiate Guidelines Network (SIGN); 2012.

  43. Choe HS, Lee SJ, Yang SS, Hamasuna R, Yamamoto S, Cho YH, et al. Summary of the UAA-AAUS guidelines for urinary tract infections. Int J Urol. 2018;25(3):175–85. https://doi.org/10.1111/iju.13493.

    Article  PubMed  Google Scholar 

  44. • Köves B, Cai T, Veeratterapillay R, Pickard R, Seisen T, Lam TB, et al. Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel. Eur Urol. 2017;72(6):865–8. https://doi.org/10.1016/j.eururo.2017.07.014. Recent systematic review and meta-analysis of the evidence about treating AB. Currently the only strong evidence to treat AB is prior to endourological procedures.

    Article  PubMed  Google Scholar 

  45. Brubaker L, Carberry C, Nardos R, Carter-Brooks C, Lowder JL. American Urogynecologic Society Best-Practice Statement: Recurrent Urinary Tract Infection in Adult Women. Female Pelvic Med Reconstr Surg. 2018;24(5):321–35. https://doi.org/10.1097/spv.0000000000000550.

    Article  PubMed  Google Scholar 

  46. Anger J, Lee U, Ackerman AL, Chou R, Chughtai B, Clemens JQ, et al. Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline. J Urol. 2019;202(2):282–9. https://doi.org/10.1097/ju.0000000000000296.

    Article  PubMed  Google Scholar 

  47. Epp A, Larochelle A. No. 250-Recurrent Urinary Tract Infection. J Obstet Gynaecol Canada. 2017;39(10):e422–31. https://doi.org/10.1016/j.jogc.2017.08.017.

    Article  Google Scholar 

  48. Jung C, Brubaker L. The etiology and management of recurrent urinary tract infections in postmenopausal women. Climacteric. 2019;22(3):242–9. https://doi.org/10.1080/13697137.2018.1551871.

    Article  PubMed  PubMed Central  Google Scholar 

  49. Dune TJ, Price TK, Hilt EE, Thomas-White KJ, Kliethermes S, Brincat C, et al. Urinary Symptoms and Their Associations With Urinary Tract Infections in Urogynecologic Patients. Obstet Gynecol. 2017;130(4):718–25. https://doi.org/10.1097/aog.0000000000002239.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Caron F, Galperine T, Flateau C, Azria R, Bonacorsi S, Bruyère F, et al. Practice guidelines for the management of adult community-acquired urinary tract infections. Med Maladies Infect. 2018;48(5):327–58. https://doi.org/10.1016/j.medmal.2018.03.005.

    Article  CAS  Google Scholar 

  51. Watson JR, Sánchez PJ, Spencer JD, Cohen DM, Hains DS. Urinary Tract Infection and Antimicrobial Stewardship in the Emergency Department. Pediatr Emerg Care. 2018;34(2):93–5. https://doi.org/10.1097/pec.0000000000000688.

    Article  PubMed  Google Scholar 

  52. Shapiro T, Dalton M, Hammock J, Lavery R, Matjucha J, Salo DF. The prevalence of urinary tract infections and sexually transmitted disease in women with symptoms of a simple urinary tract infection stratified by low colony count criteria. Acad Emerg Med Off J Soc Acad Emerg Med. 2005;12(1):38–44. https://doi.org/10.1197/j.aem.2004.08.051.

    Article  Google Scholar 

  53. Robinson D, Åkervall S, Wagg A, Chapple C, Milsom I, Gyhagen M. Prevalence and predictors of overactive bladder in nonpregnant nulliparous women below 65 years of age. Int Urogynecol J. 2018;29(4):531–7. https://doi.org/10.1007/s00192-017-3435-z.

    Article  PubMed  Google Scholar 

  54. Nik-Ahd F, Lenore Ackerman A, Anger J. Recurrent Urinary Tract Infections in Females and the Overlap with Overactive Bladder. Curr Urol Rep. 2018;19(11):94. https://doi.org/10.1007/s11934-018-0839-3.

    Article  PubMed  Google Scholar 

  55. Kranz J, Schmidt S, Lebert C, Schneidewind L, Mandraka F, Kunze M, et al. The 2017 Update of the German Clinical Guideline on Epidemiology, Diagnostics, Therapy, Prevention, and Management of Uncomplicated Urinary Tract Infections in Adult Patients: Part 1. Urol Int. 2018;100(3):263–70. https://doi.org/10.1159/000486138.

    Article  PubMed  Google Scholar 

  56. Portman DJ, Gass ML. Genitourinary syndrome of menopause: new terminology for vulvovaginal atrophy from the International Society for the Study of Women’s Sexual Health and the North American Menopause Society. Menopause (New York, NY). 2014;21(10):1063–8. https://doi.org/10.1097/gme.0000000000000329.

    Article  Google Scholar 

  57. Mumm JN, Osterman A, Ruzicka M, Stihl C, Vilsmaier T, Munker D, et al. Urinary Frequency as a Possibly Overlooked Symptom in COVID-19 Patients: Does SARS-CoV-2 Cause Viral Cystitis? Eur Urol. 2020;78(4):624–8. https://doi.org/10.1016/j.eururo.2020.05.013.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  58. Hartley S, Valley S, Kuhn L, Washer LL, Gandhi T, Meddings J, et al. Overtreatment of asymptomatic bacteriuria: identifying targets for improvement. Infect Control Hosp Epidemiol. 2015;36(4):470–3. https://doi.org/10.1017/ice.2014.73.

    Article  PubMed  Google Scholar 

  59. Viswanath NA, Shanmugam P, Rompicherla V, Education K, Shanmugam P. A clinico bacteriological profile of urinary tract infections occurring in patients with pre-existing urinary tract diseases in a tertiary care hospital. Ann Trop Med Public Health. 2020;23(S20):SP232222. https://doi.org/10.36295/ASRO.2020.232222.

    Article  Google Scholar 

  60. Wiley Z, Jacob JT, Burd EM. Targeting Asymptomatic Bacteriuria in Antimicrobial Stewardship: the Role of the Microbiology Laboratory. J Clin Microbiol. 2020;58(5). https://doi.org/10.1128/jcm.00518-18.

  61. Kass EH. Asymptomatic infections of the urinary tract. Trans Assoc Am Phys. 1956;69:56–64.

    CAS  PubMed  Google Scholar 

  62. Hooton TM, Roberts PL, Cox ME, Stapleton AE. Voided midstream urine culture and acute cystitis in premenopausal women. N Engl J Med. 2013;369(20):1883–91. https://doi.org/10.1056/NEJMoa1302186.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Naboka YL, Mavzyiutov AR, Kogan MI, Gudima IA, Ivanov SN, Naber KG. Does Escherichia coli have pathogenic potential at a low level of bacteriuria in recurrent, uncomplicated urinary tract infection? Int J Antimicrob Agents. 2020;56(1): 105983. https://doi.org/10.1016/j.ijantimicag.2020.105983.

    Article  CAS  PubMed  Google Scholar 

  64. • Hochstedler BR, Burnett L, Price TK, Jung C, Wolfe AJ, Brubaker L. Urinary microbiota of women with recurrent urinary tract infection: collection and culture methods. Int Urogynecol J. 2021. https://doi.org/10.1007/s00192-021-04780-4. In this study, clinically-significant differences can be found between culturing the urine with standard urine culture or Expanded quantitative urine culture, and also between culturing urine from midstream voided and catheterized specimens.

  65. Mouraviev V, McDonald M. An implementation of next generation sequencing for prevention and diagnosis of urinary tract infection in urology. Can J Urol. 2018;25(3):9349–56.

    PubMed  Google Scholar 

  66. Wu YR, Rego LL, Christie AL, Lavelle RS, Alhalabi F, Zimmern PE. Recurrent Urinary Tract Infections Due to Bacterial Persistence or Reinfection in Women-Does This Factor Impact Upper Tract Imaging Findings? J Urol. 2016;196(2):422–8. https://doi.org/10.1016/j.juro.2016.01.111.

    Article  PubMed  Google Scholar 

  67. Pagano MJ, Barbalat Y, Theofanides MC, Edokpolo L, James MB, Cooper KL. Diagnostic yield of cystoscopy in the evaluation of recurrent urinary tract infection in women. Neurourol Urodyn. 2017;36(3):692–6. https://doi.org/10.1002/nau.22998.

    Article  PubMed  Google Scholar 

  68. Antimicrobial resistance: global report on surveillance. Geneva, Switzerland: World Health Organization; April 2014.

  69. Prioritization of pathogens to guide discovery. research and development of new antibiotics for drug resistant bacterial infections, including tuberculosis. Geneva: World Health Organization; 2017.

    Google Scholar 

  70. Antimicrobial Resistance Division, National Action Plans and Monitoring and Evaluation. Global action plan on antimicrobial resistance. Geneva, Switzerland: 2015.

  71. Dellit TH, Owens RC, McGowan JE Jr, Gerding DN, Weinstein RA, Burke JP, et al. Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America guidelines for developing an institutional program to enhance antimicrobial stewardship. Clin Infect Dis. 2007;44(2):159–77. https://doi.org/10.1086/510393.

    Article  PubMed  Google Scholar 

  72. Lüthje P, Hirschberg AL, Brauner A. Estrogenic action on innate defense mechanisms in the urinary tract. Maturitas. 2014;77(1):32–6. https://doi.org/10.1016/j.maturitas.2013.10.018.

    Article  CAS  PubMed  Google Scholar 

  73. Huang W, Chen Y, Liu Y, Zhang Q, Yu Z, Mou L, et al. Roles of ERβ and GPR30 in Proliferative Response of Human Bladder Cancer Cell to Estrogen. Biomed Res Int. 2015;2015: 251780. https://doi.org/10.1155/2015/251780.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Xu S, Yu S, Dong D, Lee LTO. G Protein-Coupled Estrogen Receptor: A Potential Therapeutic Target in Cancer. Frontiers in Endocrinology. 2019;10(725). https://doi.org/10.3389/fendo.2019.00725.

  75. Lüthje P, Brauner H, Ramos NL, Övregaard A, Gläser R, Hirschberg AL, et al. Estrogen Supports Urothelial Defense Mechanisms. Sci Transl Med. 2013;5(190):190ra80-ra80. https://doi.org/10.1126/scitranslmed.3005574.

    Article  CAS  PubMed  Google Scholar 

  76. Pham T, Kaul A, Hart A, Goluszko P, Moulds J, Nowicki S, et al. dra-related X adhesins of gestational pyelonephritis-associated Escherichia coli recognize SCR-3 and SCR-4 domains of recombinant decay-accelerating factor. Infect Immun. 1995;63(5):1663–8. https://doi.org/10.1128/iai.63.5.1663-1668.1995.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Beerepoot MAJ, Geerlings SE, van Haarst EP, van Charante NM, ter Riet G. Nonantibiotic Prophylaxis for Recurrent Urinary Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. J Urol. 2013;190(6):1981–9. https://doi.org/10.1016/j.juro.2013.04.142.

    Article  CAS  PubMed  Google Scholar 

  78. Larenas-Linnemann D, Rodríguez-Pérez N, Arias-Cruz A, Blandón-Vijil MV, Del Río-Navarro BE, Estrada-Cardona A, et al. Enhancing innate immunity against virus in times of COVID-19: Trying to untangle facts from fictions. World Allergy Org J. 2020;13(11): 100476. https://doi.org/10.1016/j.waojou.2020.100476.

    Article  Google Scholar 

  79. Benito-Villalvilla C, Cirauqui C, Diez-Rivero CM, Casanovas M, Subiza JL, Palomares O. MV140, a sublingual polyvalent bacterial preparation to treat recurrent urinary tract infections, licenses human dendritic cells for generating Th1, Th17, and IL-10 responses via Syk and MyD88. Mucosal Immunol. 2017;10(4):924–35. https://doi.org/10.1038/mi.2016.112.

    Article  CAS  PubMed  Google Scholar 

  80. Mitroulis I, Ruppova K, Wang B, Chen L-S, Grzybek M, Grinenko T, et al. Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity. Cell. 2018;172(1):147-61.e12. https://doi.org/10.1016/j.cell.2017.11.034.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  81. Prattley S, Geraghty R, Moore M, Somani BK. Role of Vaccines for Recurrent Urinary Tract Infections: A Systematic Review. Eur Urol Focus. 2020;6(3):593–604. https://doi.org/10.1016/j.euf.2019.11.002.

    Article  PubMed  Google Scholar 

  82. Wade DT, Cooper J, Peckham N, Belci M. Immunotherapy to reduce frequency of urinary tract infections in people with neurogenic bladder dysfunction; a pilot randomised, placebo-controlled trial. Clin Rehabil. 2020;34(12):1458–64. https://doi.org/10.1177/0269215520946065.

    Article  PubMed  PubMed Central  Google Scholar 

  83. Krebs J, Fleischli S, Stoyanov J, Pannek J. Effects of oral immunomodulation therapy on urinary tract infections in individuals with chronic spinal cord injury-A retrospective cohort study. Neurourol Urodyn. 2019;38(1):346–52. https://doi.org/10.1002/nau.23859.

    Article  CAS  PubMed  Google Scholar 

  84. Wade D, Cooper J, Derry F, Taylor J. Uro-Vaxom® versus placebo for the prevention of recurrent symptomatic urinary tract infections in participants with chronic neurogenic bladder dysfunction: a randomised controlled feasibility study. Trials. 2019;20(1):223. https://doi.org/10.1186/s13063-019-3275-x.

    Article  PubMed  PubMed Central  Google Scholar 

  85. Nickel JC, Saz-Leal P, Doiron RC. Could sublingual vaccination be a viable option for the prevention of recurrent urinary tract infection in Canada? A systematic review of the current literature and plans for the future. Can Urol Assoc J. 2020;14(8):281–7. https://doi.org/10.5489/cuaj.6690.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Aziminia N, Hadjipavlou M, Philippou Y, Pandian SS, Malde S, Hammadeh MY. Vaccines for the prevention of recurrent urinary tract infections: a systematic review. BJU Int. 2019;123(5):753–68. https://doi.org/10.1111/bju.14606.

    Article  PubMed  Google Scholar 

  87. Adamus-Białek W, Wawszczak M, Arabski M, Majchrzak M, Gulba M, Jarych D, et al. Ciprofloxacin, amoxicillin, and aminoglycosides stimulate genetic and phenotypic changes in uropathogenic Escherichia coli strains. Virulence. 2019;10(1):260–76. https://doi.org/10.1080/21505594.2019.1596507.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Lewis D. Furadantin® (nitrofurantoin) Oral Suspension. Food and Drug Administration (FDA). 2020. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/009175Orig1s048lbl.pdf.

  89. NITROFURANTOÍNA (FURANTOÍNA®): NUEVAS RESTRICCIONES DE USO. Ministerio de Sanidad, Servicios Sociales e Igualdad: Agencia Española de Medicamentos y Productos Sanitarios (AEMPS)2016 7/22/2016 Contract No.: MUH (FV), 16/2016.

  90. Wingert A, Pillay J, Sebastianski M, Gates M, Featherstone R, Shave K, et al. Asymptomatic bacteriuria in pregnancy: systematic reviews of screening and treatment effectiveness and patient preferences. BMJ Open. 2019;9(3): e021347. https://doi.org/10.1136/bmjopen-2017-021347.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Kazemier BM, Koningstein FN, Schneeberger C, Ott A, Bossuyt PM, de Miranda E, et al. Maternal and neonatal consequences of treated and untreated asymptomatic bacteriuria in pregnancy: a prospective cohort study with an embedded randomised controlled trial. Lancet Infect Dis. 2015;15(11):1324–33. https://doi.org/10.1016/s1473-3099(15)00070-5.

    Article  PubMed  Google Scholar 

  92. Angelescu K, Nussbaumer-Streit B, Sieben W, Scheibler F, Gartlehner G. Benefits and harms of screening for and treatment of asymptomatic bacteriuria in pregnancy: a systematic review. BMC Pregnancy Childbirth. 2016;16(1):336. https://doi.org/10.1186/s12884-016-1128-0.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Rodriguez-Mañas L. Urinary tract infections in the elderly: a review of disease characteristics and current treatment options. Drugs in context. 2020;9. https://doi.org/10.7573/dic.2020-4-13.

  94. Eberle CM, Winsemius D, Garibaldi RA. Risk Factors and Consequences of Bacteriuria in Non-Catheterized Nursing Home Residents. J Gerontol. 1993;48(6):M266–71. https://doi.org/10.1093/geronj/48.6.M266.

    Article  CAS  PubMed  Google Scholar 

  95. Mayne S, Bowden A, Sundvall PD, Gunnarsson R. The scientific evidence for a potential link between confusion and urinary tract infection in the elderly is still confusing - a systematic literature review. BMC Geriatr. 2019;19(1):32. https://doi.org/10.1186/s12877-019-1049-7.

    Article  PubMed  PubMed Central  Google Scholar 

  96. Colgan R, Jaffe GA, Nicolle LE. Asymptomatic Bacteriuria. Am Fam Phys. 2020;102(2):99–104.

    Google Scholar 

  97. Dinh A, Davido B, Duran C, Bouchand F, Gaillard JL, Even A, et al. Urinary tract infections in patients with neurogenic bladder. Med Maladies Infect. 2019;49(7):495–504. https://doi.org/10.1016/j.medmal.2019.02.006.

    Article  CAS  Google Scholar 

  98. Coussement J, Scemla A, Hougardy JM, Sberro-Soussan R, Amrouche L, Catalano C, et al. Prevalence of asymptomatic bacteriuria among kidney transplant recipients beyond two months post-transplant: A multicenter, prospective, cross-sectional study. PLoS One. 2019;14(9): e0221820. https://doi.org/10.1371/journal.pone.0221820.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  99. Kotagiri P, Chembolli D, Ryan J, Hughes PD, Toussaint ND. Urinary Tract Infections in the First Year Post-Kidney Transplantation: Potential Benefits of Treating Asymptomatic Bacteriuria. Transpl Proc. 2017;49(9):2070–5. https://doi.org/10.1016/j.transproceed.2017.07.008.

    Article  CAS  Google Scholar 

  100. • Goldman JD, Julian K. Urinary tract infections in solid organ transplant recipients: Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice. Clin Transplant. 2019;33(9): e13507. https://doi.org/10.1111/ctr.13507. Societyguidelinesaboutinfectiuoustreatmentintransplantrecipients.ItdoesnotrecommendtreatingABinthesepatients,atleastafterthe2firstmonths.

    Article  PubMed  Google Scholar 

  101. Mukherjee D, Sharma S, Nair RK, Datt B, Arora D, Rao A. Urinary tract infection in renal transplant recipients at a tertiary care center in India. Saudi J Kidney Dis Transplant. 2018;29(2):361–8. https://doi.org/10.4103/1319-2442.229294.

    Article  Google Scholar 

  102. van Delden C, Stampf S, Hirsch HH, Manuel O, Meylan P, Cusini A, et al. Burden and Timeline of Infectious Diseases in the First Year After Solid Organ Transplantation in the Swiss Transplant Cohort Study. Clin Infect Dis. 2020;71(7):e159–69. https://doi.org/10.1093/cid/ciz1113.

    Article  PubMed  PubMed Central  Google Scholar 

  103. Rodríguez Sánchez MP, Afanador Rubio DC, Luna IM, García Padilla PK, Contreras Villamizar KM, González González CA, et al. Impact of Complicated Urinary Tract Infection on Renal Graft Function. Transpl Proc. 2020;52(4):1173–7. https://doi.org/10.1016/j.transproceed.2020.01.066.

    Article  Google Scholar 

  104. Al Midani A, Elands S, Collier S, Harber M, Shendi AM. Impact of Urinary Tract Infections in Kidney Transplant Recipients: A 4-Year Single-Center Experience. Transpl Proc. 2018;50(10):3351–5. https://doi.org/10.1016/j.transproceed.2018.08.022.

    Article  CAS  Google Scholar 

  105. Origüen J, López-Medrano F, Fernández-Ruiz M, Polanco N, Gutiérrez E, González E, et al. Should Asymptomatic Bacteriuria Be Systematically Treated in Kidney Transplant Recipients? Results From a Randomized Controlled Trial. Am J Transplant Off J Am Soc Transplant Am Soc Transplant Surg. 2016;16(10):2943–53. https://doi.org/10.1111/ajt.13829.

    Article  Google Scholar 

  106. Sabé N, Oriol I, Melilli E, Manonelles A, Bestard O, Polo C, et al. Antibiotic Treatment Versus No Treatment for Asymptomatic Bacteriuria in Kidney Transplant Recipients: A Multicenter Randomized Trial. Open Forum Infect Dis. 2019;6(6):ofz243. https://doi.org/10.1093/ofid/ofz243.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  107. Coussement J, Scemla A, Abramowicz D, Nagler EV, Webster AC. Antibiotics for asymptomatic bacteriuria in kidney transplant recipients. Cochrane Database Syst Rev. 2018;2(2):Cd011357. https://doi.org/10.1002/14651858.CD011357.pub2.

    Article  PubMed  Google Scholar 

  108. Coussement J, Kamar N, Matignon M, Weekers L, Scemla A, Giral M, et al. Antibiotics versus no therapy in kidney transplant recipients with asymptomatic bacteriuria (BiRT): a pragmatic, multicentre, randomized, controlled trial. Clin Microbiol Infect. 2021;27(3):398–405. https://doi.org/10.1016/j.cmi.2020.09.005.

    Article  CAS  PubMed  Google Scholar 

  109. Gerber L, Gaspert A, Braghetti A, Zwahlen H, Wüthrich R, Zbinden R, et al. Ureaplasma and Mycoplasma in kidney allograft recipients-A case series and review of the literature. Transplant Infect Dis. 2018;20(5): e12937. https://doi.org/10.1111/tid.12937.

    Article  Google Scholar 

  110. Coussement J, Argudín MA, Heinrichs A, Racapé J, de Mendonça R, Nienhaus L, et al. Host and microbial factors in kidney transplant recipients with Escherichia coli acute pyelonephritis or asymptomatic bacteriuria: a prospective study using whole-genome sequencing. Nephrol Dial Transplant. 2019;34(5):878–85. https://doi.org/10.1093/ndt/gfy292.

    Article  CAS  PubMed  Google Scholar 

  111. Abdo-Cuza AA, Gómez-Bravo MA, Pérez-Bernal JB, Suárez-López J, Gómez-Peire F, Leiva-Torres JL, et al. Health Care-Associated Infection in Solid Organ Transplant Recipients. Transpl Proc. 2020;52(2):509–11. https://doi.org/10.1016/j.transproceed.2019.12.010.

    Article  Google Scholar 

  112. Sayin Kutlu S, Aybek Z, Tekin K, Okke D, Akalin S, Altintas S, et al. Is short course of antimicrobial therapy for asymptomatic bacteriuria before urologic surgical procedures sufficient? J Infect Dev Ctries. 2012;6(2):143–7. https://doi.org/10.3855/jidc.1781.

    Article  PubMed  Google Scholar 

  113. Yamamoto S, Ishikawa K, Hayami H, Nakamura T, Miyairi I, Hoshino T, et al. JAID/JSC Guidelines for Clinical Management of Infectious Disease 2015 - Urinary tract infection/male genital infection. J Infect Chemother. 2017;23(11):733–51. https://doi.org/10.1016/j.jiac.2017.02.002.

    Article  PubMed  Google Scholar 

  114. Ramos-Castaneda JA, Ruano-Ravina A, Munoz-Price LS, Toro-Bermúdez R, Ruiz-Londoño D, Segura-Cardona AM, et al. Risk of infection in patients undergoing urologic surgery based on the presence of asymptomatic bacteriuria: A prospective study. Am J Infect Control. 2019;47(12):1474–8. https://doi.org/10.1016/j.ajic.2019.06.024.

    Article  PubMed  Google Scholar 

  115. • Mohee AR, Gascoyne-Binzi D, West R, Bhattarai S, Eardley I, Sandoe JA. Bacteraemia during Transurethral Resection of the Prostate: What Are the Risk Factors and Is It More Common than We Think? PLoS One. 2016;11(7):e0157864. https://doi.org/10.1371/journal.pone.0157864. Outstanding study showing that there is no relationship between AB and bacteriemia in TUR-P: different microorganisms cause these two entities.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. Qi DZ, Lehman K, Dewan K, Kirimanjeswara G, Raman JD. Preoperative urine culture is unnecessary in asymptomatic men prior to prostate needle biopsy. Int Urol Nephrol. 2018;50(1):21–4. https://doi.org/10.1007/s11255-017-1752-2.

    Article  CAS  PubMed  Google Scholar 

  117. Herr HW. Should antibiotics be given prior to outpatient cystoscopy? A plea to urologists to practice antibiotic stewardship. Eur Urol. 2014;65(4):839–42. https://doi.org/10.1016/j.eururo.2013.08.054.

    Article  PubMed  Google Scholar 

  118. Zhao LC, Meeks JJ, Helfand BT, Ross FR, Herr HW, Kundu SD. Screening urine analysis before bacille Calmette-Guérin instillation does not reduce the rate of infectious complications. BJU Int. 2012;109(12):1819–21. https://doi.org/10.1111/j.1464-410X.2011.10735.x.

    Article  PubMed  Google Scholar 

  119. Hirakauva EY, Bianchi-Ferraro A, Zucchi EVM, Kajikawa MM, Girão M, Sartori MGF, et al. Incidence of Bacteriuria after Urodynamic Study with or without Antibiotic Prophylaxis in Women with Urinary Incontinence. Rev Bras Ginecol Obstet. 2017;39(10):534–40. https://doi.org/10.1055/s-0037-1604066.

    Article  PubMed  Google Scholar 

  120. Wu XY, Cheng Y, Xu SF, Ling Q, Yuan XY, Du GH. Prophylactic Antibiotics for Urinary Tract Infections after Urodynamic Studies: A Meta-Analysis. Biomed Res Int. 2021;2021:6661588. https://doi.org/10.1155/2021/6661588.

    Article  PubMed  PubMed Central  Google Scholar 

  121. Aharony S, Przydacz M, Van Ba OL, Corcos J. Does asymptomatic bacteriuria increase the risk of adverse events or modify the efficacy of intradetrusor onabotulinumtoxinA injections? Neurourol Urodyn. 2020;39(1):203–10. https://doi.org/10.1002/nau.24169.

    Article  CAS  PubMed  Google Scholar 

  122. Yassa RR, Khalfaoui MY, Veravalli K, Evans DA. Pre-operative urinary tract infection: is it a risk factor for early surgical site infection with hip fracture surgery? A retrospective analysis. JRSM Open. 2017;8(3):2054270416675083. https://doi.org/10.1177/2054270416675083.

    Article  PubMed  PubMed Central  Google Scholar 

  123. Schmitt DR, Schneider AM, Brown NM. Impact of Perioperative Urinary Tract Infection on Surgical Site Infection in Patients Undergoing Primary Hip and Knee Arthroplasty. J Arthroplasty. 2020;35(10):2977–82. https://doi.org/10.1016/j.arth.2020.05.025.

    Article  PubMed  Google Scholar 

  124. Gallegos Salazar J, O’Brien W, Strymish JM, Itani K, Branch-Elliman W, Gupta K. Association of Screening and Treatment for Preoperative Asymptomatic Bacteriuria With Postoperative Outcomes Among US Veterans. JAMA Surg. 2019;154(3):241–8. https://doi.org/10.1001/jamasurg.2018.4759.

    Article  PubMed  Google Scholar 

  125. • Lamb MJ, Baillie L, Pajak D, Flynn J, Bansal V, Simor A, et al. Elimination of Screening Urine Cultures Prior to Elective Joint Arthroplasty. Clin Infect Dis. 2017;64(6):806–9. https://doi.org/10.1093/cid/ciw848. RecommendationofanInfectiousSocietyagainstABscreeningpriortoelectivearthroplasties.

    Article  PubMed  Google Scholar 

  126. Hellinger WC, Haehn DA, Heckman MG, Irizarry Alvarado JM, Bosch W, Pai SL. Improving Value of Care: Cessation of Screening Urine Culture Prior to Orthopedic and Spinal Surgery. Mayo Clin Proc Innov Qual Outcomes. 2020;4(2):126–31. https://doi.org/10.1016/j.mayocpiqo.2019.12.007.

    Article  PubMed  PubMed Central  Google Scholar 

  127. Rodríguez-Pardo D, Del Toro MD, Guío-Carrión L, Escudero-Sánchez R, Fernández-Sampedro M, García-Viejo M, et al. Role of asymptomatic bacteriuria on early periprosthetic joint infection after hip hemiarthroplasty. BARIFER randomized clinical trial. Eur J Clin Microbiol Infect Dis. 2021. https://doi.org/10.1007/s10096-021-04241-2.

  128. Partridge JSL, Daly M, Hemsley C, Shah Z, Sathanandan K, Mainwaring C, et al. Using implementation science to develop and implement a guideline to reduce unnecessary preoperative testing for asymptomatic bacteriuria prior to elective arthroplasty. J Bone Joint Infect. 2020;6(3):57–62. https://doi.org/10.5194/jbji-6-57-2020.

    Article  Google Scholar 

  129. Sousa RJG, Abreu MA, Wouthuyzen-Bakker M, Soriano AV. Is Routine Urinary Screening Indicated Prior To Elective Total Joint Arthroplasty? A Systematic Review and Meta-Analysis. J Arthroplasty. 2019;34(7):1523–30. https://doi.org/10.1016/j.arth.2019.03.034.

    Article  PubMed  Google Scholar 

  130. Sendi P, Borens O, Wahl P, Clauss M, Uçkay I. Management of Asymptomatic Bacteriuria, Urinary Catheters and Symptomatic Urinary Tract Infections in Patients Undergoing Surgery for Joint Replacement: A Position Paper of the Expert Group “Infection” of swissorthopaedics. J Bone Joint Infect. 2017;2(3):154–9. https://doi.org/10.7150/jbji.20425.

    Article  Google Scholar 

  131. Fitzpatrick MA, Suda KJ, Burns SP, Poggensee L, Ramanathan S, Evans CT. Pre-operative screening for asymptomatic bacteriuria and associations with post-operative outcomes in patients with spinal cord injury. J Spinal Cord Med. 2019;42(2):255–9. https://doi.org/10.1080/10790268.2018.1451237.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David Hernández-Hernández.

Ethics declarations

Conflict of Interest

David Hernandez-Hernandez reports speaker honorarium from Pierre Fabre, Astellas, Asofarma, Lacer, Almirall and Alter; and travel grants from Pierre Fabre and Lacer, all outside of the submitted work.

Barbara Padilla-Fernandez reports personal fees and other from QPharma, outside the submitted work.

David Castro Diaz reports other from Pierre Fabre, other from Astellas, other from Medtronic, other from Lacer, other from Boston Scientific, all outside the submitted work.

Yanira Ortega-Gonzalez declares no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This article is part of the Topical Collection on Inflammatory/Infectious Bladder Disorders

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hernández-Hernández, D., Padilla-Fernández, B., Ortega-González, M.Y. et al. Recurrent Urinary Tract Infections and Asymptomatic Bacteriuria in Adults. Curr Bladder Dysfunct Rep 17, 1–12 (2022). https://doi.org/10.1007/s11884-021-00638-z

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11884-021-00638-z

Keywords

Profiles

  1. David Hernández-Hernández