Opinion Statement
Dysphagia is a common problem in the elderly population with an especially high prevalence in hospitalized and institutionalized patients. If inadequately addressed, dysphagia leads to significant morbidity and contributes to decreased quality of life. Dysphagia can be categorized as emanating from either an oropharyngeal or esophageal process. A disproportionate number of elderly patients suffer from oropharyngeal dysphagia with a multifactorial etiology. Historically, treatment options have been limited and included mostly supportive care with a focus on dietary modification, food avoidance, and swallow rehabilitation. Nascent technologies such as the functional luminal imaging probe (FLIP) and advances in esophageal manometry are improving our understanding of the pathophysiology of oropharyngeal dysphagia. Recent developments in the treatment of specific causes of oropharyngeal dysphagia, including endoscopic balloon dilations for upper esophageal sphincter (UES) dysfunction, show promise and are expected to enhance with further research. Esophageal dysphagia is also common in the elderly and more commonly due to an identifiable cause. The full breadth of treatment options is frequently unavailable to elderly patients due to comorbidities and overall functional status. However, the increasing availability of less invasive solutions to specific esophageal pathologies has augmented the number of treatment options available to this population, where an individualized approach to patient care is paramount. This review focuses on the evaluation and management of dysphagia in the elderly and delineates how standard and novel therapeutics are contributing to more nuanced and personalized management.

Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.References
Papers of particular interest, published recently, have been highlighted as: • Of importance
Wirth R, et al. Oropharyngeal dysphagia in older persons—from pathophysiology to adequate intervention: a review and summary of an international expert meeting. Clin Interv Aging. 2016;11:189–208.
Ekberg O, Feinberg MJ. Altered swallowing function in elderly patients without dysphagia: radiologic findings in 56 cases. AJR Am J Roentgenol. 1991;156(6):1181–4.
Rommel N, Hamdy S. Oropharyngeal dysphagia: manifestations and diagnosis. Nat Rev Gastroenterol Hepatol. 2016;13(1):49–59.
Khan A, Carmona R, Traube M. Dysphagia in the elderly. Clin Geriatr Med. 2014;30(1):43–53.
Baijens LW, et al. European Society for Swallowing Disorders-European Union Geriatric Medicine Society white paper: oropharyngeal dysphagia as a geriatric syndrome. Clin Interv Aging. 2016;11:1403–28.
Cruz-Jentoft AJ, et al. Sarcopenia: European consensus on definition and diagnosis: report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010;39(4):412–23.
Feng X, et al. Aging-related geniohyoid muscle atrophy is related to aspiration status in healthy older adults. J Gerontol A Biol Sci Med Sci. 2013;68(7):853–60.
Ren J, et al. Deterioration of the pharyngo-UES contractile reflex in the elderly. Laryngoscope. 2000;110(9):1563–6.
Jones CA, Ciucci MR. Multimodal swallowing evaluation with high-resolution manometry reveals subtle swallowing changes in early and mid-stage Parkinson disease. J Parkinsons Dis. 2016;6(1):197–208.
Troche MS, et al. Respiratory-swallowing coordination and swallowing safety in patients with Parkinson’s disease. Dysphagia. 2011;26(3):218–24.
Affoo RH, et al. Swallowing dysfunction and autonomic nervous system dysfunction in Alzheimer’s disease: a scoping review of the evidence. J Am Geriatr Soc. 2013;61(12):2203–13.
Byeon H. Analysis of dysphagia risk using the modified dysphagia risk assessment for the community-dwelling elderly. J Phys Ther Sci. 2016;28(9):2507–9.
Giraldo-Cadavid, L.F., et al., Accuracy of endoscopic and videofluoroscopic evaluations of swallowing for oropharyngeal dysphagia. Laryngoscope, 2016. doi:10.1002/lary.26419.
Park, C.H., et al., Ability of high-resolution manometry to determine feeding method and to predict aspiration pneumonia in patients with dysphagia. Am J Gastroenterol, 2017. doi:10.1038/ajg.2017.81.
• Meyer JP, et al. Three-dimensional manometry of the upper esophageal sphincter in swallowing and nonswallowing tasks. Laryngoscope. 2016;126(11):2539–45. doi:10.1136/bcr-2015-211726This is a novel technology that may help in deciding on treatment for UES dysfunction.
Hoffman MR, et al. Classification of high-resolution manometry data according to videofluoroscopic parameters using pattern recognition. Otolaryngol Head Neck Surg. 2013;149(1):126–33.
Hirano I, Pandolfino JE, Boeckxstaens GE. Functional lumen imaging probe for the management of esophageal disorders: expert review from the Clinical Practice Updates Committee of the AGA Institute. Clin Gastroenterol Hepatol. 2017;15(3):325–34.
Ata-Lawenko RM, Lee YY. Emerging roles of the endolumenal functional lumen imaging probe in gastrointestinal motility disorders. J Neurogastroenterol Motil. 2017;23(2):164–70.
Regan J, et al. A new evaluation of the upper esophageal sphincter using the functional lumen imaging probe: a preliminary report. Dis Esophagus. 2013;26(2):117–23.
Regan J, et al. New measures of upper esophageal sphincter distensibility and opening patterns during swallowing in healthy subjects using EndoFLIP(R). Neurogastroenterol Motil. 2013;25(1):e25–34.
Kahrilas PJ, et al. The Chicago classification of esophageal motility disorders, v3.0. Neurogastroenterol Motil. 2015;27(2):160–74.
Gupta A, Epstein JB, Sroussi H. Hyposalivation in elderly patients. J Can Dent Assoc. 2006;72(9):841–6.
Oppenlander ME, et al. Dysphagia due to anterior cervical hyperosteophytosis. Surg Neurol. 2009;72(3):266–70. discussion 270-1
Kim YK, et al. Effectiveness of rehabilitative balloon swallowing treatment on upper esophageal sphincter relaxation and pharyngeal motility for neurogenic dysphagia. Ann Rehabil Med. 2015;39(4):524–34.
Dou Z, et al. The effect of different catheter balloon dilatation modes on cricopharyngeal dysfunction in patients with dysphagia. Dysphagia. 2012;27(4):514–20.
Solt J, et al. Primary cricopharyngeal dysfunction: treatment with balloon catheter dilatation. Gastrointest Endosc. 2001;54(6):767–71.
Veenker EA, Andersen PE, Cohen JI. Cricopharyngeal spasm and Zenker’s diverticulum. Head Neck. 2003;25(8):681–94.
Bonavina L, et al. Long-term results of endosurgical and open surgical approach for Zenker diverticulum. World J Gastroenterol. 2007;13(18):2586–9.
El Sharkawi A, et al. Swallowing and voice effects of Lee Silverman Voice Treatment (LSVT): a pilot study. J Neurol Neurosurg Psychiatry. 2002;72(1):31–6.
Speyer R, et al. Effects of therapy in oropharyngeal dysphagia by speech and language therapists: a systematic review. Dysphagia. 2010;25(1):40–65.
• Michou E, et al. Repetitive transcranial magnetic stimulation: a novel approach for treating oropharyngeal dysphagia. Curr Gastroenterol Rep. 2016;18(2):10. Further treatment options for the UES which if validated in large-scale studies could improve our ability to treat oropharyngeal dysphagia in this population
• Yabunaka K, et al. Videofluoroscopy-guided balloon dilatation for treatment of severe pharyngeal dysphagia. Diagn Interv Radiol. 2015;21(2):173–6. Further treatment options for the UES which if validated in large-scale studies could improve our ability to treat oropharyngeal dysphagia in this population
Suttrup I, Warnecke T. Dysphagia in Parkinson’s disease: pathophysiology, diagnosis and therapy. Fortschr Neurol Psychiatr. 2016;84(Suppl 1):S18–23.
Troche MS, et al. Swallowing and deep brain stimulation in Parkinson’s disease: a systematic review. Parkinsonism Relat Disord. 2013;19(9):783–8.
Garcia-Peris P, et al. Long-term prevalence of oropharyngeal dysphagia in head and neck cancer patients: impact on quality of life. Clin Nutr. 2007;26(6):710–7.
Silander E, et al. Impact of prophylactic percutaneous endoscopic gastrostomy on malnutrition and quality of life in patients with head and neck cancer: a randomized study. Head Neck. 2012;34(1):1–9.
Axelsson L, et al. Effect of prophylactic percutaneous endoscopic gastrostomy tube on swallowing in advanced head and neck cancer: a randomized controlled study. Head Neck. 2017;39(5):908–15.
Attwood SE, et al. Long-term safety of proton pump inhibitor therapy assessed under controlled, randomised clinical trial conditions: data from the SOPRAN and LOTUS studies. Aliment Pharmacol Ther. 2015;41(11):1162–74.
Freedberg DE, Kim LS, Yang YX. The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association. Gastroenterology. 2017;152(4):706–15.
Liang WT, et al. Stretta radiofrequency for gastroesophageal reflux disease-related respiratory symptoms: a prospective 5-year study. Minerva Chir. 2014;69(5):293–9.
Testoni PA, et al. Long-term efficacy of transoral incisionless fundoplication with Esophyx (Tif 2.0) and factors affecting outcomes in GERD patients followed for up to 6 years: a prospective single-center study. Surg Endosc. 2015;29(9):2770–80.
Zacherl J, et al. Endoscopic anterior fundoplication with the Medigus Ultrasonic Surgical Endostapler (MUSE) for gastroesophageal reflux disease: 6-month results from a multi-center prospective trial. Surg Endosc. 2015;29(1):220–9.
Katz PO, Gerson LB, Vela MF. Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol. 2013;108(3):308–28. quiz 329
Skubleny, D., et al., LINX magnetic esophageal sphincter augmentation versus Nissen fundoplication for gastroesophageal reflux disease: a systematic review and meta-analysis. Surg Endosc. 2016;31(8):3078-3084.
Triadafilopoulos G. Endoscopic options for gastroesophageal reflux: where are we now and what does the future hold? Curr Gastroenterol Rep. 2016;18(9):47.
Kavitt RT, Hirano I, Vaezi MF. Diagnosis and treatment of eosinophilic esophagitis in adults. Am J Med. 2016;129(9):924–34.
Poincloux L, Rouquette O, Abergel A. Endoscopic treatment of benign esophageal strictures: a literature review. Expert Rev Gastroenterol Hepatol. 2017;11(1):53–64.
Siersema PD, de Wijkerslooth LR. Dilation of refractory benign esophageal strictures. Gastrointest Endosc. 2009;70(5):1000–12.
Novacek G. Plummer-Vinson syndrome. Orphanet J Rare Dis. 2006;1:36.
Hoffman RM, Jaffe PE. Plummer-Vinson syndrome. A case report and literature review. Arch Intern Med. 1995;155(18):2008–11.
Janssen M, et al. Dysphagia lusoria: clinical aspects, manometric findings, diagnosis, and therapy. Am J Gastroenterol. 2000;95(6):1411–6.
Arifputera A, et al. An unusual case of dysphonia and dysphagia. Singap Med J. 2014;55(2):e31–3.
Abdul Haziz, S.R., I. Bickle, and V.H. Chong, Dysphagia aortica: a rare cause of dysphagia. BMJ Case Rep, 2015. 2015.
Kahrilas PJ, Boeckxstaens G. The spectrum of achalasia: lessons from studies of pathophysiology and high-resolution manometry. Gastroenterology. 2013;145(5):954–65.
Vaezi MF, Pandolfino JE, Vela MF. ACG clinical guideline: diagnosis and management of achalasia. Am J Gastroenterol. 2013;108(8):1238–49. quiz 1250
Salvador R, et al. Laparoscopic Heller myotomy can be used as primary therapy for esophageal achalasia regardless of age. J Gastrointest Surg. 2014;18(1):106–11. discussion 112
Boeckxstaens GE, et al. Pneumatic dilation versus laparoscopic Heller’s myotomy for idiopathic achalasia. N Engl J Med. 2011;364(19):1807–16.
Moonen A, et al. Long-term results of the European achalasia trial: a multicentre randomised controlled trial comparing pneumatic dilation versus laparoscopic Heller myotomy. Gut. 2016;65(5):732–9.
Rohof WO, et al. Outcomes of treatment for achalasia depend on manometric subtype. Gastroenterology. 2013;144(4):718–25. quiz e13-4.
Ou YH, et al. High-resolution manometric subtypes as a predictive factor for the treatment of achalasia: a meta-analysis and systematic review. J Dig Dis. 2016;17(4):222–35.
Ihara E, et al. Diagnosis and treatment strategy of achalasia subtypes and esophagogastric junction outflow obstruction based on high-resolution manometry. Digestion. 2017;95(1):29–35.
Burmeister S. Review of current diagnosis and management of diffuse esophageal spasm, nutcracker esophagus/spastic nutcracker and hypertensive lower esophageal sphincter. Curr Opin Otolaryngol Head Neck Surg. 2013;21(6):543–7.
Louis H, et al. Distal esophageal spasm treated by peroral endoscopic myotomy. Am J Gastroenterol. 2012;107(12):1926–7.
Khan MA, et al. Is POEM the answer for management of spastic esophageal disorders? A systematic review and meta-analysis. Dig Dis Sci. 2017;62(1):35–44.
Ntoumazios SK, et al. Esophageal involvement in scleroderma: gastroesophageal reflux, the common problem. Semin Arthritis Rheum. 2006;36(3):173–81.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
Scott M. Smukalla, Irina Dimitrova, and Jeremy M. Feintuch declare that they have no conflict of interest.
Abraham Khan is on the speaker bureau for EndoGastric Solutions in 2017. This company does work with GERD, which is a topic covered in minor detail in this paper.
Human and Animal Rights and Informed Consent
This article does not contain any studies with human or animal subjects performed by any of the authors.
Additional information
This article is part of the Topical Collection on Intractable Disease in the Elderly: When Conventional Therapy Fails
Rights and permissions
About this article
Cite this article
Smukalla, S.M., Dimitrova, I., Feintuch, J.M. et al. Dysphagia in the Elderly. Curr Treat Options Gastro 15, 382–396 (2017). https://doi.org/10.1007/s11938-017-0144-0
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11938-017-0144-0