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Recent findings on the organization of central nervous system structures involved in the innervation of endocrine glands and other organs; observations obtained by the transneuronal viral double-labeling technique

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Abstract

This review summarizes the data obtained with the aid of the recently introduced dual viral tracing technique, which uses isogenic recombinants of pseudorabies virus that express unique reporter gene. This approach made possible to explore simultaneously neural circuits of two organs. The results of these studies indicate: (1) there are neurons innervating exclusively a given organ; (2) left-sided predominance in the supraspinal innervation of the endocrine glands (adrenal, ovary) studied, so far; (3) viral co-infection of neurons, i.e., special neuronal populations coexist in different brain areas that are transsynaptically connected with both paired endocrine and non-endocrine organs, endocrine glands and non-endocrine organs, and organs of bodily systems other than the endocrine one. The number of common neurons seems to be related to the need of coordinating action of different systems. The data on co-infection of neurons suggest that the central nervous system has the capacity to coordinate different organ functions via common brain neurons providing supraspinal innervation of the organs.

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Acknowledgments

This work was supported in part by grants from the National Research Fund (OTKA T046624 to I.G.), the Ministry of Health (ETT 448/2006 to I.G.), and the Hungarian Academy of Sciences. The authors are grateful to Miss Mariann Akócsi for preparation of the manuscript.

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Authors and Affiliations

  1. Neuromorphological and Neuroendocrine Research Laboratory, Department of Human Morphology and Developmental Biology, Hungarian Academy of Sciences and Semmelweis University, Tűzoltó u. 58, 1094, Budapest, Hungary

    Ida Gerendai, Ida E. Tóth & Béla Halász

  2. Department of Human Morphology and Developmental Biology, Semmelweis University, Tűzoltó u. 58, 1094, Budapest, Hungary

    Ida Gerendai

  3. Department of Biology, Faculty of Medicine, University of Szeged, Somogyi Béla u. 4, 6720, Szeged, Hungary

    Zsolt Boldogkői

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  1. Ida Gerendai
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Gerendai, I., Tóth, I.E., Boldogkői, Z. et al. Recent findings on the organization of central nervous system structures involved in the innervation of endocrine glands and other organs; observations obtained by the transneuronal viral double-labeling technique. Endocr 36, 179–188 (2009). https://doi.org/10.1007/s12020-009-9189-8

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