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Welcome to RVC Repository

RVC Research Online is a repository of the research outputs produced by staff from the Royal Veterinary College (RVC). The aims of the repository are (i) to provide an institutional archive of RVC's research outputs, (ii) to provide access to these outputs and support open science, and (iii) to increase the reach and impact of RVC's research.



Latest Additions

Desmitis of the palmar or plantar ligaments of the proximal interphalangeal joint: A descriptive case series (2025)
Journal Article
Peeters, M., Ott, S., van Veggel, E., Berner, D., & Perrier, M. (2025). Desmitis of the palmar or plantar ligaments of the proximal interphalangeal joint: A descriptive case series. Equine Veterinary Journal, https://doi.org/10.1111/evj.14547

BackgroundLimited reports in the literature are available regarding desmitis of the palmar/plantar ligaments of the proximal interphalangeal joint (PL-PIPJ); the clinical significance of such injuries is unknown.ObjectivesTo describe the ability to d... Read More about Desmitis of the palmar or plantar ligaments of the proximal interphalangeal joint: A descriptive case series.

Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential (2025)
Journal Article
Pedrosa, A., Castillo-Kauil, A., Kravchuk, Y., Reynolds, L., Williams, B., Moore, D., Lang, C., Allanki, S., Maniati, E., Hardas, A., Haj, J., Drake, R., Cleaver, J., Foster, J., Kim, J., Stern, E., Sosabowski, J., Fruhwirth, G., Sahai, E., Wald, O., & Hodivala-Dilke, K. (2025). Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential. Journal of Pathology, https://doi.org/10.1002/path.6435

Lung cancer is the leading cause of cancer-related death globally. To better understand the biology of lung cancer, mouse models have been developed using either tail vein-injected tumour cell lines or genetically modified mice. The current gold-stan... Read More about Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential.

Repeated Low‐Level Inflammatory Challenge Leads to Alterations in the TNF‐CXCL10 Signalling Pathway in Mouse Cerebral Endothelial Cells In Vitro (2025)
Journal Article
Ritson, M., Xia, D., Wheeler‐Jones, C., & Stolp, H. B. (2025). Repeated Low‐Level Inflammatory Challenge Leads to Alterations in the TNF‐CXCL10 Signalling Pathway in Mouse Cerebral Endothelial Cells In Vitro. Journal of Neurochemistry, 169(6), e70130. https://doi.org/10.1111/jnc.70130

The mechanism by which chronic systemic inflammation contributes to cerebral endothelial dysfunction and neurological disorders is unclear, although endothelial inflammatory signalling is considered a cornerstone of this process. Here, we have perfor... Read More about Repeated Low‐Level Inflammatory Challenge Leads to Alterations in the TNF‐CXCL10 Signalling Pathway in Mouse Cerebral Endothelial Cells In Vitro.

Emulating the EPIC trial using VetCompass primary-care data: causal effects of pimobendan in UK dogs with grade IV/VI heart murmurs (2025)
Journal Article
Pegram, C., Diaz-Ordaz, K., Brodbelt, D. C., Chang, Y.-M., Boswood, A., Wilshaw, J., Reep, C. A. T., Balling, S., Sahota, J., Church, D. B., & O’Neill, D. G. (2025). Emulating the EPIC trial using VetCompass primary-care data: causal effects of pimobendan in UK dogs with grade IV/VI heart murmurs. PLoS ONE, 20(6), e0325695. https://doi.org/10.1371/journal.pone.0325695

Frequency, Risk Factors, and Mortality for Diabetes Mellitus in 1 225 130 Cats Under Primary Veterinary Care in the United Kingdom in 2019 (2025)
Journal Article
Waite, O., O'Neill, D. G., Wright, E., Gostelow, R., Jepson, R. E., & Brodbelt, D. C. (2025). Frequency, Risk Factors, and Mortality for Diabetes Mellitus in 1 225 130 Cats Under Primary Veterinary Care in the United Kingdom in 2019. Herpetological Conservation and Biology, 39(4), e70161. https://doi.org/10.1111/jvim.70161

Background: Diabetes mellitus (DM) is a common endocrinopathy in cats. General population epidemiology and mortality
studies on DM are lacking.
Objectives: Describe the incidence, prevalence, risk factors, and mortality for DM in cats under primary... Read More about Frequency, Risk Factors, and Mortality for Diabetes Mellitus in 1 225 130 Cats Under Primary Veterinary Care in the United Kingdom in 2019.