Compile Data Set for Download or QSAR
Report error Found 49 Enz. Inhib. hit(s) with all data for entry = 50019649 Sort by
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621378(CHEMBL5396363)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human CK1 delta expressed in Escherichia coli BL21 cells using PLSRTL-pS-VA-pS-LPGL as substrate meas...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621377(CHEMBL5419541)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human CK1 delta expressed in Escherichia coli BL21 cells using PLSRTL-pS-VA-pS-LPGL as substrate meas...More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 2.90nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human CK1 delta expressed in Escherichia coli BL21 cells using PLSRTL-pS-VA-pS-LPGL as substrate meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621381(CHEMBL5435963)
Affinity DataIC50: 11nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621385(CHEMBL5428427)
Affinity DataIC50: 11nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621377(CHEMBL5419541)
Affinity DataIC50: 17nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629142(US20230339900, Example 119 | 4-[3-(5-Fluoro-2-pyri...)
Affinity DataIC50: 32nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621378(CHEMBL5396363)
Affinity DataIC50: 36nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621376(CHEMBL5401718)
Affinity DataIC50: 45nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621379(CHEMBL5396125)
Affinity DataIC50: 52nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 62nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 71nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629112(US20230339900, Example 89 | 4-[3-(5-Fluoro-2-pyrid...)
Affinity DataIC50: 71nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621380(CHEMBL5431829)
Affinity DataIC50: 81nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 93nMAssay Description:Inhibition of CK1 epsilon (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform epsilon(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 110nMAssay Description:Inhibition of CK1 epsilon (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621377(CHEMBL5419541)
Affinity DataIC50: 140nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629108(US20230339900, Example 85 | 4-(3-(5-Fluoropyridin-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629108(US20230339900, Example 85 | 4-(3-(5-Fluoropyridin-...)
Affinity DataIC50: 250nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621377(CHEMBL5419541)
Affinity DataIC50: 250nMAssay Description:Inhibition of p38 beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621378(CHEMBL5396363)
Affinity DataIC50: 250nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621384(CHEMBL5407201)
Affinity DataIC50: 300nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621386(CHEMBL5412695)
Affinity DataIC50: 340nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621383(CHEMBL5426768)
Affinity DataIC50: 370nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform alpha(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 410nMAssay Description:Inhibition of CK1 alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621378(CHEMBL5396363)
Affinity DataIC50: 780nMAssay Description:Inhibition of p38 beta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform alpha(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 790nMAssay Description:Inhibition of CK1 alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 930nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 11(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629043(US20230339900, Example 20 | US20230339900, Example...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of p38 beta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621381(CHEMBL5435963)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621379(CHEMBL5396125)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetTRAF2 and NCK-interacting protein kinase(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of TNIK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCasein kinase I isoform delta(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621387(CHEMBL5431001)
Affinity DataIC50: 3.40E+3nMAssay Description:Displacement of kinase tracer 8 from NanoLuc-tagged CK1 delta (unknown origin) transfected in CHO cells by BRET assayMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621380(CHEMBL5431829)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629112(US20230339900, Example 89 | 4-[3-(5-Fluoro-2-pyrid...)
Affinity DataIC50: 6.20E+3nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetMitogen-activated protein kinase 14(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM629142(US20230339900, Example 119 | 4-[3-(5-Fluoro-2-pyri...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of p38 alpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2C9(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2C19(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2D6(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 3A4(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate incubated for 5 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 2C8(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed
TargetCytochrome P450 1A2(Human)
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50621382(CHEMBL5095777)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes incubated for 10 mins in presence of NADPH by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoSimilars
In Depth
Date in BDB:
12/16/2024
Entry Details
PubMed