Abstract
MOST investigators believe that reticulo-endothelial cells, through ingestion of the antigen, play an initial part in the synthesis of antibody1,2. Study of phagocytosis of particulate antigens lends support to this concept3. Since antibody is merely one form of protein, its formation could theoretically occur immediately; however, it appears to be delayed several hours or days4.
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BENSCH, K., SIMBONIS, S., HILL, R. et al. Phagocytosis and Cell Division. Nature 183, 476–477 (1959). https://doi.org/10.1038/183476a0
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DOI: https://doi.org/10.1038/183476a0