Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letter
  • Published:

Enterohepatic Circulation of Bilirubin

Nature volume 192, page 372 (1961)Cite this article

Abstract

THE enterohepatic circulation of bile pigment has been the subject of protracted debate. Recirculation of bilirubin, and its bacterial reduction products, the urobilinoids, has been postulated and denied1. The availability of bilirubin labelled with carbon-14 in this Laboratory2 has obviated many of the problems previously inherent in the study of bilirubin metabolism. The following is a preliminary report of investigations of the enterohepatic circulation of bilirubin.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

Buy this article

  • Purchase on SpringerLink
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Broun, G. O., McMaster, P. D., and Rous, P., J. Exp. Med., 37, 699 (1923). McMaster, P. D., and Elman, R., J. Exp. Med., 41, 719 (1925). Baumgartel, T., Arch. inn. Med., 1, 40 (1949). Watson, C. J., in Handbook of Hematology, edit. by H. Downey (Paul B. Hoeber, Inc., New York, 1938). With, K. T., Biologie der Gallenfarbstoffe (Georg Thieme Verlag, Stuttgart, 1960).

    Google Scholar 

  2. Ostrow, J. D., Hammaker, L., and Schmid, R., J. Clin. Invest., 40, 1442 (1961).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Thorndike Memorial Laboratory and Second and Fourth (Harvard) Medical Services, Boston City Hospital,

    ROGER LESTER, J. DONALD OSTROW & RUDI SCHMID

  2. Department of Medicine, Harvard Medical School, Boston, Mass

    ROGER LESTER, J. DONALD OSTROW & RUDI SCHMID

Authors
  1. ROGER LESTER
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. J. DONALD OSTROW
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. RUDI SCHMID
    View author publications

    You can also search for this author inPubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

LESTER, R., OSTROW, J. & SCHMID, R. Enterohepatic Circulation of Bilirubin. Nature 192, 372 (1961). https://doi.org/10.1038/192372a0

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/192372a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing