Abstract
ALMOST twenty years ago1, we put forward a working hypothesis that viruses may originate in nucleoproteins in cells, and in 19432 we discovered that the viral nuclear polyhedrosis of larvæ of Bombyx mori can be induced by a metabolite. The later development of work on induction has suggested3 that the polyhedral virus would be derived from the chromosomal segment containing the genes controlling the synthesis of protease and deoxyribonuclease. We have now demonstrated that the pre-viral genome contains a gene synthesizing an alkaline protease and is located in the chromosome of healthy silkworms.
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YAMAFUJI, K., YOSHIHARA, F. A Gene synthesizing Protease and a Pre-Viral Genome in Silkworms. Nature 192, 782 (1961). https://doi.org/10.1038/192782a0
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DOI: https://doi.org/10.1038/192782a0
