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Patterns of Interferon Appearance in Mice injected with Bacteria or Bacterial Endotoxin

Nature volume 204, page 712 (1964)Cite this article

Abstract

PREVIOUS work1 has shown that the intravenous injection of large numbers of live Brucella abortus into chickens results in the appearance in the serum of a viral inhibitor with the properties of interferon. Inhibitor reached maximum levels about 12 h after inoculation. It was also reported that large numbers of Newcastle disease virus (NDV) particles produced maximum levels of interferon in chickens about 12 h after intravenous inoculation. Injection of large doses of other gram-positive and -negative bacteria or bacterial endotoxins failed to produce demonstrable inhibitors in the circulation of chickens at 6–8 h.

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Authors and Affiliations

  1. Department of Microbiology, University of Pittsburgh, School of Medicine, Pittsburgh

    WARREN R. STINEBRING & JULIUS S. YOUNGNER

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  1. WARREN R. STINEBRING
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  2. JULIUS S. YOUNGNER
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STINEBRING, W., YOUNGNER, J. Patterns of Interferon Appearance in Mice injected with Bacteria or Bacterial Endotoxin. Nature 204, 712 (1964). https://doi.org/10.1038/204712a0

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