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Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

Nature volume 351, pages 290–296 (1991)Cite this article

Abstract

The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the groove adhere.

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References

  1. Zinkernagel, R. M. & Doherty, P. C. Nature 248, 701–702 (1974).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Townsend, A. R. et al. Cell 44, 959–968 (1986).

    Article  CAS  PubMed  Google Scholar 

  3. Bjorkman, P. J. et al. Nature 329, 512–518 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Rötzschke, O. et al. Nature 348, 252–254 (1990).

    Article  ADS  PubMed  Google Scholar 

  5. Van Bleek, G. M. & Nathenson, S. G. Nature 348, 213–216 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Garrett, T. P. J., Saper, M. A., Bjorkman, P. J., Strominger, J. L. & Wiley, D. C. Nature 343, 692–696 (1989).

    Article  ADS  Google Scholar 

  7. Rötzschke, O., Falk, K., Wallny, H.-J., Faath, S. & Rammensee, H.-G. Science 249, 283–287 (1990).

    Article  ADS  PubMed  Google Scholar 

  8. Falk, K., Rötzschke, O. & Rammensee, H.-G. Nature 348, 248–251 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  9. Shimonkevitz, R., Kappler, J., Marrack, P. & Grey, H. J. exp. Med. 158, 303–316 (1983).

    Article  CAS  PubMed  Google Scholar 

  10. Demotz, S., Grey, H. M., Appella, E. & Sette, A. Nature 343, 682–684 (1989).

    Article  ADS  Google Scholar 

  11. Bjorkman, P. J. et al. Nature 329, 506–512 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. DeLisi, C. & Berzofsky, J. A. Proc. natn. Acad. Sci. U.S.A. 82, 7048–7052 (1985).

    Article  ADS  CAS  Google Scholar 

  13. Rothbard, J. B. & Taylor, W. R. EMBO J. 7, 93–100 (1988).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Cornette, J. L., Margalit, H., DeLisi, C. & Berzofsky, J. A. Meth. Enzym. 178, 611–633 (1989).

    Article  CAS  PubMed  Google Scholar 

  15. Sette, A. et al. Proc. natn. Acad. Sci. U.S.A. 86, 3296–3300 (1989).

    Article  ADS  CAS  Google Scholar 

  16. Maryanski, J. L., Verdini, A. S., Weber, P. C., Salemme, F. R. & Corradin, G. Cell 60, 63–72 (1990).

    Article  CAS  PubMed  Google Scholar 

  17. Bastin, J., Rothbard, J., Davey, J., Jones, I. & Townsend, A. J. exp. Med. 165, 1508–1523 (1987).

    Article  CAS  PubMed  Google Scholar 

  18. Bjorkman, P. J. & Davis, M. M. Cold Spring Harb. Symp. quant. Biol. 54, 365–374 (1989).

    Article  CAS  PubMed  Google Scholar 

  19. Bouillot, M. et al. Nature 339, 473–475 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  20. Frelinger, J. A., Gotch, F. M. Zweerink, H., Wain, E. & McMichael, A. J. J. exp. Med. 172, 827–834 (1990).

    Article  CAS  PubMed  Google Scholar 

  21. Schild, H., Rötzschke, O., Kalbacher, H. & Rammensee, H.-G. Science 247, 1587–1589 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  22. Townsend, A. et al. Nature 340, 443–448 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  23. Elliott, T., Townsend, A. & Cerundolo, V. Nature 348, 195–197 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Cerundolo, V. et al. Nature 345, 449–452 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  25. Rüsch, E., Kuon, W. & Hämmerling, G. J. Trans. Proc. 15, 2093–2096 (1983).

    Google Scholar 

  26. Lemke, H., Hämmerling, G. J. & Hämmerling, U. Immunol. Rev. 47, 175–206 (1979).

    Article  CAS  PubMed  Google Scholar 

  27. Ozato, K. & Sachs, D. H. J. Immun. 126, 317–321 (1981).

    CAS  PubMed  Google Scholar 

  28. Parham, P. & Brodsky, F. M. Hum. Immun. 3, 277–299 (1981).

    Article  CAS  PubMed  Google Scholar 

  29. Taylor, P. M., Davey, J., Howland, K., Rothbard, J. B. & Askonas, B. A. Immunogenetics 26, 267–272 (1987).

    Article  CAS  PubMed  Google Scholar 

  30. Braciale, T. J. et al. J. exp. Med. 166, 678–692 (1987).

    Article  CAS  PubMed  Google Scholar 

  31. Braciale, T. J., Sweetser, M. T., Morrison, L. A., Kittlesen, D. J. & Braciale, V. L. Proc. natn. Acad. Sci. U.S.A. 86, 277–281 (1989).

    Article  ADS  CAS  Google Scholar 

  32. Kuwano, K., Braciale, T. J. & Ennis, F. A. FASEB J. 2, 2221 (1988).

    Google Scholar 

  33. Maryanski, J. L., Pala, P., Cerottini, J. C. & Corradin, G. J. exp. Med. 167, 1391–1405 (1988).

    Article  CAS  PubMed  Google Scholar 

  34. Maryanski, J. L., Pala, P., Corradin, G., Jordan, B. R. & Cerottini, J. C. Nature 324, 578–579 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  35. Sibille, C. et al. J. exp. Med. 172, 35–45 (1990).

    Article  CAS  PubMed  Google Scholar 

  36. Romero, P. et al. Nature 341, 323–326 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  37. Weiss, W. R. et al. J. exp. Med. 171, 763–773 (1990).

    Article  CAS  PubMed  Google Scholar 

  38. Kast, W. M. et al. Cell 59, 603–614 (1989).

    Article  CAS  PubMed  Google Scholar 

  39. Oldstone, M. B. A., Whitton, J. L., Lewicki, H. & Tishon, A. J. exp. Med. 168, 559–570 (1988).

    Article  CAS  PubMed  Google Scholar 

  40. Tevethia, S. S. et al. J. Virol. 64, 1192–1200 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  41. Carbone, F. R. & Bevan, M. J. J. exp. Med. 169, 603–612 (1989).

    Article  CAS  PubMed  Google Scholar 

  42. Schumacher, T. N. M. et al. Cell 62, 563–567 (1990).

    Article  CAS  PubMed  Google Scholar 

  43. Walker, B. D. et al. Proc. natn. Acad. Sci. U.S.A. 86, 9514–9518 (1989).

    Article  ADS  CAS  Google Scholar 

  44. Gotch, F., McMichael, A. & Rothbard, J. J. exp. Med. 168, 2045–2057 (1988).

    Article  CAS  PubMed  Google Scholar 

  45. Santos-Aguado, J., Crimmins, M. A. V., Mentzer, S. J., Burakoff, S. J. & Strominger, J. L. Proc. natn. Acad. Sci. U.S.A. 86, 8936–8940 (1989).

    Article  ADS  CAS  Google Scholar 

  46. Claverie, J. M. et al. Eur. J. Immun. 18, 1547–1553 (1988).

    Article  CAS  Google Scholar 

  47. Falk, K. et al. J. exp. Med. (in the press).

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Author notes

  1. Stefan Stevanovié and Günther Jung: Institut für Organische Chemie, Universität Tübingen, Auf der Morgenstelle 18, W-7400 Tübingen, Germany

  2. Hans-Georg Rammensee: To whom correspondence should be addressed. 290

Authors and Affiliations

  1. Max-Planck-Institut für Biologie, Abteilung Immungenetik, Corrensstrasse 42, W-7400, Tübingen, Germany

    Kirsten Falk, Olaf Rötzschke, Stefan Stevanovié, Günther Jung & Hans-Georg Rammensee

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  1. Kirsten Falk
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  2. Olaf Rötzschke
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  3. Stefan Stevanovié
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  4. Günther Jung
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  5. Hans-Georg Rammensee
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Falk, K., Rötzschke, O., Stevanovié, S. et al. Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature 351, 290–296 (1991). https://doi.org/10.1038/351290a0

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