Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Letters to Editor
  • Published:

Ultrastructure of Human C1q Protein

Nature New Biology volume 238, pages 117–118 (1972)Cite this article

Abstract

THE first component (C1) in the complement system may be defined functionally as a macromolecule capable of binding to antigen-antibody complexes and inducing the sequential reactions of this system. C1 consists of three distinct proteins named C1q, C1r and C1s which,in serum, form a macromolecular complex held together by calcium ions1. The C1q protein was first isolated by Müller-Eberhard and Kunkel2 and Taranta et al.3. The ultrastructure of this basic, heat-labile 11S protein is outlined here.

Access through your institution
Buy or subscribe

This is a preview of subscription content, access via your institution

Access options

Access through your institution

References

  1. Lepow, I. H., Naff, G. B., Todd, E. W., Pensky, J., and Hinz, jun., C. F., J. Exp, Med., 117, 983 (1963).

    Article  CAS  Google Scholar 

  2. Müller-Eberhard, H. J., and Kunkel, H. G., Proc. Soc. Exp. Biol. Med., 106, 291 (1960).

    Article  Google Scholar 

  3. Taranta, A., Weiss, H. S., and Franklin, E. C., Nature, 189, 239 (1961).

    Article  CAS  Google Scholar 

  4. Yonemasu, K., and Stroud, R. M. J., Immunology, 106, 304 (1971).

    CAS  Google Scholar 

  5. Ewald, R. W., and Schubart, A. F. J., Immunology, 97, 100 (1966).

    CAS  Google Scholar 

  6. Green, N. M., Advan. Immunol., 11, 1 (1969).

    Article  CAS  Google Scholar 

  7. Svehag, S.-E., and Bloth, B., Acta Path. Microbiol. Scand., B, 78, 260 (1970).

    CAS  Google Scholar 

  8. Müller-Eberhard, H. J., Ann. Rev. Biochem., 38, 389 (1969).

    Article  Google Scholar 

  9. Shelton, E., Yonemasu, K., and Stroud, R. M. J., Immunology, 107, 310 (1971).

    Google Scholar 

  10. Polley, M. J., Immunology, 107, 322 (1971).

    Google Scholar 

  11. Shelton, E., Yonemasu, K., and Stroud, R. M., Proc. US Nat. Acad. Sci., 69, 65 (1972).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Immunology, National Bacteriological Laboratory, 105 21, Stockholm

    S.-E. SVEHAG, L. MANHEM & B. BLOTH

Authors
  1. S.-E. SVEHAG
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. L. MANHEM
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. B. BLOTH
    View author publications

    You can also search for this author inPubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

SVEHAG, SE., MANHEM, L. & BLOTH, B. Ultrastructure of Human C1q Protein. Nature New Biology 238, 117–118 (1972). https://doi.org/10.1038/newbio238117a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/newbio238117a0

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing