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Gut microbiota

Microbiota promote gut healing

Nature Reviews Gastroenterology & Hepatology volume 13, page 189 (2016)Cite this article

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Wounds in the gut are associated with microenvironment changes that encourage the growth of microbial species that promote healing, according to new research.

Damage to the intestinal mucosa can occur as a result of physical trauma, infection or inflammatory conditions. Although the intestinal wound healing response in humans and mice is well described, the role of the gut microbiota in the process has not been investigated. “We used the mouse endoscope-wounding model we and others have used in past reports to induce a controlled and uniform lesion in the colonic mucosa of wild-type mice without associated harmful effects,” explains author Andrew Neish.

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References

  1. Alam, A. et al. The microenvironment of injured murine gut elicits a local pro-restitutive microbiota. Nat. Microbiol. 1, 15021 (2016)

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  1. Hugh Thomas
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Thomas, H. Microbiota promote gut healing. Nat Rev Gastroenterol Hepatol 13, 189 (2016). https://doi.org/10.1038/nrgastro.2016.31

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  • DOI: https://doi.org/10.1038/nrgastro.2016.31

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