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Mitosis

A safety net for successful mitosis

Nature Reviews Molecular Cell Biology volume 15, pages 220–221 (2014)Cite this article

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During mitosis, the SAC proteins mitotic arrest deficient 1 (MAD1) and MAD2 are recruited to unattached kinetochores to promote the formation of the mitotic checkpoint complex (MCC). The MCC sequesters CDC20 to prevent activation of the APC/C (anaphase-promoting complex, also known as the cyclosome) and hence delay anaphase. During interphase, MAD1 and MAD2 are associated with nuclear pore complexes (NPCs), and a large proportion of MAD2 is already bound to CDC20. Given that NPCs have been implicated in regulatory functions other than nuclear transport, Rodriguez-Bravo et al. investigated the functions of NPC-tethered MAD1 during interphase.

MAD1 is continuously required for CDC20 inhibition in cells during interphase

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References

  1. Rodriguez-Bravo, V. et al. Nuclear pores protect genome integrity by assembling a premitotic and Mad1-dependent anaphase inhibitor. Cell 156, 1017–1031 (2014)

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  1. Kirsty Minton
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Minton, K. A safety net for successful mitosis. Nat Rev Mol Cell Biol 15, 220–221 (2014). https://doi.org/10.1038/nrm3777

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