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Synaptic plasticity

Ubiquitin activates synaptic plasticity

Nature Reviews Neuroscience volume 13, page 73 (2012)Cite this article

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The E3 ubiquitin ligase Neuralized facilitates long-term memory function in flies. Here the authors examined the role of its mouse orthologue, Neuralized-like protein 1A (NEURL1A), in synaptic function. They found that inhibition of NEURL1A function by the expression of a dominant negative form of the protein in the adult mouse forebrain impaired long-term potentiation (LTP) and long-term depression (LTD) at hippocampal synapses and reduced hippocampus-dependent memory formation. Overexpression of NEURL1A had the opposite effect.

inhibition of NEURL1A function ... impaired long-term potentiation (LTP) and long-term depression (LTD) at hippocampal synapses and reduced hippocampus-dependent memory formation.

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ORIGINAL RESEARCH PAPER

  1. Pavlopoulos, E. et al. Neuralized1 activates CPEB3: a function for nonproteolytic ubiquitin in synaptic plasticity and memory storage. Cell 147, 1369–1383 (2011)Article

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  1. Katherine Whalley
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Whalley, K. Ubiquitin activates synaptic plasticity. Nat Rev Neurosci 13, 73 (2012). https://doi.org/10.1038/nrn3175

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