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Transplantation

Role of AECAS in graft rejection

Nature Reviews Nephrology volume 11, page 3 (2015)Cite this article

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Evidence from clinical studies has implicated non-HLA anti-endothelial cell antibodies (AECAs) in transplant rejection. However, the pathogenic mechanisms by which these antibodies might contribute to renal allograft dysfunction are not well understood. Now, new data from Annette Jackson, Tara Sigdel, Minnie Sarwal and colleagues suggest that AECAs activate the vascular endothelium, resulting in inflammation and microvascular injury.

To investigate their role in allograft rejection, the researchers first isolated AECAs from the sera of 10 renal transplant recipients with antibody-mediated rejection (ABMR) in the absence of donor-specific HLA antibodies (HLA-DSAs). Using a proteomics approach, they identified four novel antigenic targets for these AECAs that are known to be expressed on endothelial cells: endoglin, Flt3 ligand, EDIL3 and ICAM4.

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References

  1. Jackson, A. M. et al. Endothelial cell antibodies associated with novel targets and increased rejection. J. Am. Soc. Nephrol. 10.1681/ASN.2013121277

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  1. Ellen F. Carney
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Carney, E. Role of AECAS in graft rejection. Nat Rev Nephrol 11, 3 (2015). https://doi.org/10.1038/nrneph.2014.220

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