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RSC Medicinal Chemistry

Thiochromenes and thiochromanes: a comprehensive review of their diverse biological activities and structure–activity relationship (SAR) insights

Jatin,a   Solai Murugappan,a   Shivani Kirad,a   Chandu Ala,a   Pranali Vijaykumar Kuthe,a   Chandra Sekhar Venkata Gowri Kondapalli ORCID logo b  and  Murugesan Sankaranarayanan ORCID logo *a  

* Corresponding authors

a Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Vidya Vihar, Pilani-333031, Rajasthan, India
E-mail: murugesan@pilani.bits-pilani.ac.in

b Department of Chemistry, Birla Institute of Technology and Science Pilani, Hyderabad Campus, Jawahar Nagar, Kapra Mandal, Hyderabad-500078, Telangana, India

Abstract

Thiochromene and thiochromane scaffolds, sulfur containing heterocycles, have gained significant attention in medicinal chemistry due to their diverse pharmacological activities. This review provides a comprehensive analysis of their antibacterial, antifungal, antiviral, anti-parasitic, and anticancer properties, emphasizing their therapeutic potential. SAR studies highlight key molecular modifications such as electron withdrawing substituents, sulfur oxidation, and tailored ring substitutions that enhance bioactivity, potency, and target specificity. Mechanistic insights reveal their ability to inhibit microbial enzymes, disrupt cellular pathways, and modulate key biological targets. By summarizing recent advancements, this review underscores the potential of thiochromene and thiochromane based therapeutics and encourages further research to address existing limitations and enhance their drug development prospects.

Graphical abstract: Thiochromenes and thiochromanes: a comprehensive review of their diverse biological activities and structure–activity relationship (SAR) insights

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Article information

DOI
https://doi.org/10.1039/D4MD00995A
Article type
Review Article
Submitted
16 Dec 2024
Accepted
09 Mar 2025
First published
24 Mar 2025
This article is Open Access
Creative Commons BY-NC license

RSC Med. Chem., 2025, Advance Article

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Thiochromenes and thiochromanes: a comprehensive review of their diverse biological activities and structure–activity relationship (SAR) insights

Jatin, S. Murugappan, S. Kirad, C. Ala, P. V. Kuthe, C. S. V. G. Kondapalli and M. Sankaranarayanan, RSC Med. Chem., 2025, Advance Article , DOI: 10.1039/D4MD00995A

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