Issue 6, 2025

Alkyl bistriflimidate-mediated electrochemical deaminative functionalization

Abstract

An efficient electrochemical strategy for the deaminative functionalization of alkyl amines has been described. The alkyl bistriflimidates were readily accessed by the treatment of alkyl amines with trifluoromethanesulfonic anhydride and unprecedentedly employed for C–N bond activation. They can be applied to a range of transformations, including borylation, sulfuration, selenation, sulfonation, Additionally, deaminative esterification and amidation can be performed under catalytic base conditions. The protocol features an undivided cell without the use of transition metal- or photo-catalysts and exhibits high conversion and stability in flow reactors.

Graphical abstract: Alkyl bistriflimidate-mediated electrochemical deaminative functionalization

Supplementary files

Article information

Article type
Edge Article
Submitted
07 Oct 2024
Accepted
23 Dec 2024
First published
24 Dec 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2025,16, 2682-2689

Alkyl bistriflimidate-mediated electrochemical deaminative functionalization

H. Shu, X. Tao, S. Ni, J. Liu, J. Xu, Y. Pan and Y. Wang, Chem. Sci., 2025, 16, 2682 DOI: 10.1039/D4SC06773H

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