Allelism
This extract was created in the absence of an abstract.
Excerpt
A radical reappraisal of the ideas on the divisibility of the genetic material and, more generally, of the relations between organization and function of the chromosomes started with the work of Serebrovsky and Dubinin (1929). The writings of Goldschmidt (review, 1956) over many years have had this as their central theme, and 16 years ago Muller (Raffel and Muller, 1940) stated the problems facing us with unsurpassed clarity. Referring to a tacit assumption, still current, he wrote, “… there is as yet no empiric evidence, and only doubtful theoretical ground, for assuming that the lines of demarcation between genes, as defined, on any one of these systems (crossing over, chromosome breakage, mutation and self reproduction, [my italics]) would coincide with those of any of the others … it is not far fetched to imagine that the ‘gene for scute,’ as recognized by test of allelism of its mutations, may nevertheless...
