Influence of p21ras on Phosphatidylinositol Turnover
This extract was created in the absence of an abstract.
Excerpt
The ras gene family is of great importance in human malignancy: Point mutation of these genes at a number of positions activates their oncogenic potential, resulting in mutant proteins capable of transforming cells even when expressed at relatively low levels. The mechanisms by which the activated ras-encoded 21,000-molecular-weight proteins transform cells and the roles of their normal counterparts have been the subjects of intense speculation. ras proteins bind and hydrolyze guanosine triphosphate; the hydrolytic activity is impaired in the transforming protein as compared to normal p21 (McGrath et al. 1984; Sweet et al. 1984). Localized sequence homologies exist between ras proteins and the family of mammalian GTP-binding proteins termed “G proteins,” which couple a wide variety of cell-surface receptors to intracellular enzyme systems (Lochrie et al. 1985; Medynski et al. 1985; Tanabe et al. 1985; Yatsunami et al. 1985). Both sets of proteins are also known to be peripherally associated...
