Integrated circuits and systems have emerged to play a critical role in supporting the patient-centered medical home (PCMH) model of health care delivery. PCMH model of care has been performed in National Taiwan University Hospital (NTUH), Taiwan. The wireless ECG monitoring devices capable of measuring nonlinear heart rate variability and providing GPS localization information help the cardiologists to better handle the emergency condition of heart failure. A multi-modal signaling processor has been integrated to address patient with acute coronary syndrome, ischemie stroke and subarachnoid hemorrhage and facilitate early detection of targeted events. Electro-sensing antibody probing system has also been realized for biomedicai samples. The service package of Telecare center of NTUH is composed of synchronous transmission of biometrics, mutual telephone communication, and rapid decision-making support. By integrating the bio-medical MEMS sensors with silicon circuits into mobile phones, physiological signals and vital signs can be monitored at any place and any time. With the mobile phone as a personal medical information hub, the biometrics can be sent to cloud for real-time monitoring and further analysis.